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Molecular Biology

D-Index
57
Citations
10833
World Ranking
2156
National Ranking
46

Overview

Rosa Marina Melillo is affiliated with the University of Naples Federico II in Italy. Their research primarily spans biochemistry, genetics, molecular biology, and medicine, with a focus on molecular biology, oncology, immunology, cancer research, and pharmacology.

The scientist's recent publications reflect an emphasis on cancer biology, immunotherapy, and inflammatory processes within the tumor microenvironment. Notable papers include:

  • PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells, 2021, Journal of Experimental & Clinical Cancer Research
  • In PD-1+ human colon cancer cells NIVOLUMAB promotes survival and could protect tumor cells from conventional therapies, 2022, Journal for ImmunoTherapy of Cancer
  • Probiotic Lactobacillus rhamnosus GG ( LGG ) restrains the angiogenic potential of colorectal carcinoma cells by activating a proresolving program via formyl peptide receptor 1, 2022, Molecular Oncology
  • Glucose Enhances Pro-Tumorigenic Functions of Mammary Adipose-Derived Mesenchymal Stromal/Stem Cells on Breast Cancer Cell Lines, 2022, Cancers
  • The Impact of Resolution of Inflammation on Tumor Microenvironment: Exploring New Ways to Control Cancer Progression, 2022, Cancers

Their frequent coauthors include Federica Liotti, Nella Prevete, Maria Marotta, Daniela Sorriento, and Caterina Ieranò.

Publications by Rosa Marina Melillo are concentrated in several journals with multiple contributions to Cancers, Journal of Experimental & Clinical Cancer Research, and Biomedicine & Pharmacotherapy, among others.

The main research topics covered by their work include:

  • Protein Tyrosine Phosphatases
  • S100 Proteins and Annexins
  • Immune Response and Inflammation
  • Galectins and Cancer Biology
  • Cancer Immunotherapy and Biomarkers
  • Inflammatory mediators and NSAID effects
  • Cancer Cells and Metastasis

Best Publications

  • PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas.

    Michele Grieco;Massimo Santoro;Maria Teresa Berlingieri;Rosa Marina Melillo

  • Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27 Kip1 by PKB/Akt-mediated phosphorylation in breast cancer

    Giuseppe Viglietto;Maria Letizia Motti;Paola Bruni;Rosa Marina Melillo

  • Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype.

    M Santoro;F Carlomagno;I D Hay;M A Herrmann

  • The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells

    Rosa Marina Melillo;Maria Domenica Castellone;Valentina Guarino;Valentina De Falco

  • HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity.

    Monica Fedele;Rosa Visone;Ivana De Martino;Giancarlo Troncone

  • Thyroid cancer and inflammation.

    Valentina Guarino;Maria Domenica Castellone;Elvira Avilla;Rosa Marina Melillo

  • RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.

    Massimo Santoro;Rosa Marina Melillo;Alfredo Fusco

  • Mast cells have a protumorigenic role in human thyroid cancer.

    R M Melillo;V Guarino;E Avilla;M R Galdiero

  • Minireview: RET: normal and abnormal functions.

    Massimo Santoro;Rosa Marina Melillo;Francesca Carlomagno;Giancarlo Vecchio

  • Molecular mechanisms of RET activation in human cancer.

    Massimo Santoro;Rosa Marina Melillo;Francesca Carlomagno;Alfredo Fusco

  • A Cell Proliferation and Chromosomal Instability Signature in Anaplastic Thyroid Carcinoma

    Giuliana Salvatore;Tito Claudio Nappi;Paolo Salerno;Yuan Jiang

  • Mast cells induce epithelial-to-mesenchymal transition and stem cell features in human thyroid cancer cells through an IL-8–Akt–Slug pathway

    C Visciano;F Liotti;N Prevete;G Cali

  • BRAF is a therapeutic target in aggressive thyroid carcinoma.

    Giuliana Salvatore;Valentina De Falco;Paolo Salerno;Tito Claudio Nappi

  • Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas

    Maria D Castellone;Valentina Guarino;Valentina De Falco;Francesca Carlomagno

  • Docking Protein FRS2 Links the Protein Tyrosine Kinase RET and Its Oncogenic Forms with the Mitogen-Activated Protein Kinase Signaling Cascade

    R. M. Melillo;M. Santoro;S.-H. Ong;M. Billaud

  • The TRK and RET tyrosine kinase oncogenes cooperate with ras in the neoplastic transformation of a rat thyroid epithelial cell line.

    Massimo Santoro;Rosa Marina Melillo;Michele Grieco;Maria Teresa Berlingieri

  • Signalling of the Ret receptor tyrosine kinase through the c-Jun NH2-terminal protein kinases (JNKS): evidence for a divergence of the ERKs and JNKs pathways induced by Ret.

    M. Chiariello;R. Visconti;F. Carlomagno;R. M. Melillo

  • Molecular heterogeneity of RET loss of function in Hirschsprung's disease.

    F Carlomagno;G De Vita;M T Berlingieri;V de Franciscis

  • Biological Role and Potential Therapeutic Targeting of the Chemokine Receptor CXCR4 in Undifferentiated Thyroid Cancer

    Valentina De Falco;Valentina Guarino;Elvira Avilla;Maria Domenica Castellone

  • Efficient Inhibition of RET/Papillary Thyroid Carcinoma Oncogenic Kinases by 4-Amino-5-(4-Chloro-Phenyl)-7-(t-Butyl)Pyrazolo[3,4-d]Pyrimidine (PP2)

    Francesca Carlomagno;Donata Vitagliano;Teresa Guida;Fulvio Basolo

Frequent Co-Authors

Alfredo Fusco
Alfredo Fusco University of Naples Federico II
Massimo Santoro
Massimo Santoro University of Padua
Massimo Santoro
Massimo Santoro University of Naples Federico II
Fulvio Basolo
Fulvio Basolo University of Pisa
Gianni Marone
Gianni Marone University of Naples Federico II
Giuseppe Viglietto
Giuseppe Viglietto Magna Graecia University
Paolo Miccoli
Paolo Miccoli University of Pisa
Renato Franco
Renato Franco University of Campania "Luigi Vanvitelli"
Monica Fedele
Monica Fedele National Research Council (CNR)
Amato de Paulis
Amato de Paulis University of Naples Federico II

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