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Microbiology

D-Index
59
Citations
11705
World Ranking
3289
National Ranking
91

Overview

José A. Esté is affiliated with the Autonomous University of Barcelona in Spain and has contributed to the field of Medicine with a focus on Oncology, Pulmonary and Respiratory Medicine, Infectious Diseases, Virology, and Cancer Research. Their research encompasses a range of topics, including Cancer-related Molecular Pathways, Advanced Breast Cancer Therapies, HIV/AIDS drug development and treatment, HIV Research and Treatment, Cancer Genomics and Diagnostics, Chronic Lymphocytic Leukemia Research, and HIV/AIDS Research and Interventions.

The scientist has collaborated frequently with several coauthors, notably:

  • Eva Riveira-Muñoz
  • Roger Badía
  • Eudald Felip
  • Iris Teruel
  • Mireia Margelí Vila

José A. Esté's recent publications include the following papers:

  • "Pharmacological Modulation of SAMHD1 Activity by CDK4/6 Inhibitors Improves Anticancer Therapy," published in 2020 in Cancers
  • "Targeting HIV-1 RNase H: N'-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants," published in 2020 in Viruses
  • "New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains," published in 2020 in the European Journal of Medicinal Chemistry
  • "Abstract P5-05-14: Cyclin-dependent kinases inhibitors improve antimetabolite drug potency depending on SAMHD1 expression," published in 2020 in Cancer Research
  • "Abstract P3-08-32: Predictive value of SAMHD1 expression in early relapse breast cancer," published in 2020 in Cancer Research

Frequent publication venues for their work include:

  • Cancers
  • Cancer Research
  • Viruses
  • European Journal of Medicinal Chemistry

Their research contributions predominantly address molecular pathways and therapeutic approaches related to cancer, with a strong emphasis on breast cancer and leukemias, as well as the development of antiviral compounds aimed at improving treatment options for HIV/AIDS. The combination of oncology and infectious disease research reflects a cross-disciplinary approach in their work.

Best Publications

  • AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor

    G A Donzella;D Schols;S W Lin;J A Esté

  • Inhibition of T-tropic HIV Strains by Selective Antagonization of the Chemokine Receptor CXCR4

    Dominique Schols;Sofie Struyf;Jo Van Damme;José A. Esté

  • HIV entry inhibitors.

    José A Esté;Amalio Telenti

  • Current status and challenges of antiretroviral research and therapy.

    José A. Esté;Tomas Cihlar

  • Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor fusin/CXCR-4.

    Dominique Schols;José A Esté;Geoffrey Henson;Erik De Clercq

  • Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication.

    Miguel A Martínez;Arantxa Gutiérrez;Mercedes Armand-Ugón;Julià Blanco

  • Apoptosis Control in Syncytia Induced by the HIV Type 1–Envelope Glycoprotein Complex Role of Mitochondria and Caspases

    Karine F. Ferri;Etienne Jacotot;Julià Blanco;José A. Esté

  • Secretion of interferon-γ by human macrophages demonstrated at the single-cell level after costimulation with interleukin (IL)-12 plus IL-18

    Laila Darwich;Gemma Coma;Ruth Peña;Rocio Bellido

  • Human Immunodeficiency Virus 1 Envelope Glycoprotein Complex-Induced Apoptosis Involves Mammalian Target of Rapamycin/Fkbp12-Rapamycin–Associated Protein–Mediated P53 Phosphorylation

    Maria Castedo;Karine F. Ferri;Julià Blanco;Thomas Roumier

  • Interleukin-7 in Plasma Correlates with CD4 T-Cell Depletion and May Be Associated with Emergence of Syncytium-Inducing Variants in Human Immunodeficiency Virus Type 1-Positive Individuals

    Anuska Llano;Jordi Barretina;Arantxa Gutiérrez;Julià Blanco

  • Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope

    Maria Castedo;Thomas Roumier;Julià Blanco;Karine F. Ferri

  • Novel targets for HIV therapy.

    Warner C. Greene;Zeger Debyser;Yasuhiro Ikeda;Eric O. Freed

  • T30177, an oligonucleotide stabilized by an intramolecular guanosine octet, is a potent inhibitor of laboratory strains and clinical isolates of human immunodeficiency virus type 1.

    J O Ojwang;R W Buckheit;Y Pommier;A Mazumder

  • T-Cell-Line-Tropic Human Immunodeficiency Virus Type 1 That Is Made Resistant to Stromal Cell-Derived Factor 1α Contains Mutations in the Envelope gp120 but Does Not Show a Switch in Coreceptor Use

    Dominique Schols;José A. Esté;Cecilia Cabrera;Erik De Clercq

  • Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir).

    José A. Esté;Cecilia Cabrera;Dominique Schols;Peter Cherepanov

  • Cell Cycle Control and HIV-1 Susceptibility Are Linked by CDK6-Dependent CDK2 Phosphorylation of SAMHD1 in Myeloid and Lymphoid Cells

    Eduardo Pauls;Alba Ruiz;Roger Badia;Marc Permanyer

  • Activity of a sulfated polysaccharide extracted from the red seaweed Aghardhiella tenera against human immunodeficiency virus and other enveloped viruses

    M. Witvrouw;J. A. Este;J. A. Este;M. Q. Mateu;D. Reymen

  • Shift of Clinical Human Immunodeficiency Virus Type 1 Isolates from X4 to R5 and Prevention of Emergence of the Syncytium-Inducing Phenotype by Blockade of CXCR4

    José A. Esté;Cecilia Cabrera;Julià Blanco;Arantxa Gutierrez

  • Activity of Different Bicyclam Derivatives against Human Immunodeficiency Virus Depends on Their Interaction with the CXCR4 Chemokine Receptor

    José A. Esté;Cecilia Cabrera;Erik De Clercq;Sofie Struyf

  • Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents.

    Annalaura Brai;Roberta Fazi;Cristina Tintori;Claudio Zamperini

  • HIV entry inhibitors

    José Esté

Frequent Co-Authors

Julià Blanco
Julià Blanco IrsiCaixa
Maurizio Botta
Maurizio Botta University of Siena
Giovanni Maga
Giovanni Maga National Research Council (CNR)
Jordi Barretina
Jordi Barretina Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
Erik De Clercq
Erik De Clercq Rega Institute for Medical Research
Miguel Angel Martínez
Miguel Angel Martínez Autonomous University of Barcelona
Dante Rotili
Dante Rotili Sapienza University of Rome

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Finally, for those interested in public health, the best easiest mph online programs to get into allow students to build on microbiology foundations and work toward improving community health through policy, epidemiology, and research.

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