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D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
12701
World Ranking
13755
National Ranking
978

Overview

Otmar Huber is affiliated with Friedrich Schiller University Jena in Germany with a research focus spanning biochemistry, genetics, molecular biology, and medicine. Their work includes 24 publications in the broad area of biochemistry, genetics, and molecular biology, alongside 12 publications related to medicine.

Their research extensively covers molecular biology, the primary subfield with 19 publications. Other significant subfields include neurology, oncology, immunology, and genetics, each contributing to the diverse scope of their scientific inquiry.

Huber's main research topics are varied and include:

  • Barrier Structure and Function Studies
  • Connexins and lens biology
  • S100 Proteins and Annexins
  • Cancer-related gene regulation
  • Ubiquitin and proteasome pathways
  • Wnt/β-catenin signaling in development and cancer
  • Sirtuins and Resveratrol in Medicine

Their frequent coauthors reflect ongoing collaborations with established researchers, such as:

  • Martin Schmidt (6 collaborations)
  • Sonnhild Mittag (5 collaborations)
  • Alexander Kaiser (4 collaborations)
  • Juliane Reiche (3 collaborations)
  • Jörg P. Müller (3 collaborations)

Their articles have appeared in diverse scientific journals, with multiple contributions to journals including Cells (4 publications), International Journal of Molecular Sciences (3), and Leukemia (2). Additional publications have featured in Biochimica et Biophysica Acta (BBA) - Biomembranes and the Journal of Clinical Investigation.

Key recent publications include:

  • "Post-translational modifications of tight junction transmembrane proteins and their direct effect on barrier function," 2020, Biochimica et Biophysica Acta (BBA) - Biomembranes
  • "SIRT7: an influence factor in healthy aging and the development of age-dependent myeloid stem-cell disorders," 2020, Leukemia
  • "GMPPA defects cause a neuromuscular disorder with α-dystroglycan hyperglycosylation," 2021, Journal of Clinical Investigation
  • "Tumor-Intrinsic PD-L1 Exerts an Oncogenic Function through the Activation of the Wnt/β-Catenin Pathway in Human Non-Small Cell Lung Cancer," 2022, International Journal of Molecular Sciences
  • "Identification of PARP-1, Histone H1 and SIRT-1 as New Regulators of Breast Cancer-Related Aromatase Promoter I.3/II," 2020, Cells

Best Publications

  • Nuclear localization of beta-catenin by interaction with transcription factor LEF-1.

    Otmar Huber;Reinhard Korn;John McLaughlin;Mami Ohsugi

  • E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation

    Sandra Orsulic;Otmar Huber;Hermann Aberle;Sebastian Arnold

  • A role for cadherins in tissue formation

    Lionel Larue;Christopher Antos;Stefan Butz;Otmar Huber

  • Correction: Corrigendum: Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model

    Marko Gröger;Knut Rennert;Benjamin Giszas;Elisabeth Weiß

  • Cadherins and catenins in development

    Otmar Huber;Christiane Bierkamp;Rolf Kemler

  • Embryonic heart and skin defects in mice lacking plakoglobin.

    Christiane Bierkamp;K.John Mclaughlin;Heinz Schwarz;Otmar Huber

  • Tricellulin Forms a Barrier to Macromolecules in Tricellular Tight Junctions without Affecting Ion Permeability

    Susanne M. Krug;Salah Amasheh;Jan F. Richter;Susanne Milatz

  • Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes.

    Jung Hwa Kim;Bogyou Kim;Ling Cai;Hee June Choi

  • Pontin52 and Reptin52 function as antagonistic regulators of β-catenin signalling activity

    Andreas Bauer;Sophie Chauvet;Otmar Huber;Fabrice Usseglio

  • Cleavage and shedding of E-cadherin after induction of apoptosis.

    Ulrike Steinhusen;Jörg Weiske;Volker Badock;Rudolf Tauber

  • Noggin is required for induction of the hair follicle growth phase in postnatal skin

    Vladimir A. Botchkarev;Natalia V. Botchkareva;Motonobu Nakamura;Otmar Huber

  • An alpha-E-catenin gene trap mutation defines its function in preimplantation development.

    Miguel Torres;Anastassia Stoykova;Otmar Huber;Kamal Chowdhury

  • Functional characterization of multiple transactivating elements in beta-catenin, some of which interact with the TATA-binding protein in vitro.

    Andreas Hecht;Claudia M. Litterst;Otmar Huber;Rolf Kemler

  • Pontin52, an Interaction Partner of β -catenin, Binds to the TATA Box Binding Protein

    Andreas Bauer;Otmar Huber;Rolf Kemler

  • A microfluidically perfused three dimensional human liver model.

    Knut Rennert;Sandra Steinborn;Marko Gröger;Birgit Ungerböck

  • In tight junctions, claudins regulate the interactions between occludin, tricellulin and marvelD3, which, inversely, modulate claudin oligomerization

    Jimmi Cording;Johanna Berg;Nadja Käding;Christian Bellmann

  • Modulation of Tight Junction Structure and Function by Kinases and Phosphatases Targeting Occludin

    Max Johannes Dörfel;Otmar Huber

  • The Tight Junction Protein Occludin and the Adherens Junction Protein α-Catenin Share a Common Interaction Mechanism with ZO-1

    Sebastian L. Müller;Michael Portwich;Anke Schmidt;Darkhan I. Utepbergenov

  • Modulation of BMP signaling by noggin is required for induction of the secondary (nontylotrich) hair follicles.

    Vladimir A Botchkarev;Natalia V Botchkareva;Andrei A Sharov;Keiko Funa

  • RAPID COMMUNICATION Embryonic Heart and Skin Defects in Mice Lacking Plakoglobin

    Christiane Bierkamp;K. John McLaughlin;Heinz Schwarz;Otmar Huber

Frequent Co-Authors

Rolf Kemler
Rolf Kemler Max Planck Society
Michael Fromm
Michael Fromm Charité - University Medicine Berlin
Ingolf E. Blasig
Ingolf E. Blasig Leibniz Institute for Neurobiology
Dorothee Günzel
Dorothee Günzel Charité - University Medicine Berlin
Ralf Einspanier
Ralf Einspanier Freie Universität Berlin
Petra Knaus
Petra Knaus Freie Universität Berlin
Heinz Schwarz
Heinz Schwarz Max Planck Society
Bernhard Hube
Bernhard Hube Leibniz Association
Ilse D. Jacobsen
Ilse D. Jacobsen Leibniz Association
Hans Lehrach
Hans Lehrach Max Planck Society

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