Somasekar Seshagiri

Overview

Best Publications

• Mutations in the Epidermal Growth Factor Receptor and in KRAS Are Predictive and Prognostic Indicators in Patients With Non–Small-Cell Lung Cancer Treated With Chemotherapy Alone and in Combination With Erlotinib

  David A. Eberhard;Bruce E. Johnson;Lukas C. Amler;Audrey D. Goddard

  2195
  Citations

• De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

  Ingrid E. Wertz;Karen M. O'Rourke;Honglin Zhou;Michael Eby

  2161
  Citations

• RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

  Georgia Hatzivassiliou;Kyung Song;Ivana Yen;Barbara J. Brandhuber

  1799
  Citations

• Diverse somatic mutation patterns and pathway alterations in human cancers

  Zhengyan Kan;Bijay S. Jaiswal;Jeremy Stinson;Vasantharajan Janakiraman

  1175
  Citations

• Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

  Charles M Rudin;Steffen Durinck;Eric W Stawiski;John T Poirier

  1097
  Citations

• Recurrent R-spondin fusions in colon cancer

  Somasekar Seshagiri;Eric W. Stawiski;Steffen Durinck;Zora Modrusan

  1090
  Citations

• Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma

  Robert L. Yauch;Gerrit J. P. Dijkgraaf;Bruno Alicke;Thomas Januario

  991
  Citations

• Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35

  Nancy J. Bump;Maria Hackett;Margaret Hugunin;Somasekar Seshagiri

  892
  Citations

• Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

  Ingrid E. Wertz;Saritha Kusam;Cynthia Lam;Toru Okamoto

  847
  Citations

• Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations

  Raphael Bueno;Eric W Stawiski;Leonard D Goldstein;Steffen Durinck

  834
  Citations

• Phase I/II Trial Evaluating the Anti-Vascular Endothelial Growth Factor Monoclonal Antibody Bevacizumab in Combination With the HER-1/Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Erlotinib for Patients With Recurrent Non–Small-Cell Lung Cancer

  Roy S. Herbst;David H. Johnson;Eric Mininberg;David P. Carbone

  773
  Citations

• Bcl10 activates the NF-κB pathway through ubiquitination of NEMO

  Honglin Zhou;Ingrid Wertz;Ingrid Wertz;Karen O'Rourke;Mark Ultsch

  675
  Citations

• A comprehensive transcriptional portrait of human cancer cell lines

  Christiaan Klijn;Steffen Durinck;Eric W Stawiski;Peter M Haverty

  672
  Citations

• Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients.

  Robert L. Yauch;Thomas Januario;David A. Eberhard;Guy Cavet

  651
  Citations

• The mutation spectrum revealed by paired genome sequences from a lung cancer patient

  William Lee;Zhaoshi Jiang;Jinfeng Liu;Peter M. Haverty

  635
  Citations

• The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer

  Morgan O'Hayre;José Vázquez-Prado;Irina Kufareva;Eric W. Stawiski

  615
  Citations

• A specificity map for the PDZ domain family.

  Raffi Tonikian;Yingnan Zhang;Stephen L Sazinsky;Bridget Currell

  556
  Citations

• Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer

  Clara Montagut;Alba Dalmases;Beatriz Bellosillo;Marta Crespo

  549
  Citations

• Somatic Mutations Lead to an Oncogenic Deletion of Met in Lung Cancer

  Monica Kong-Beltran;Somasekar Seshagiri;Jiping Zha;Wenjing Zhu

  539
  Citations

• Abstract LB-331: Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations

  Somasekar Seshagiri;Eric Stawiski;Leonard Goldstein;Steffen Durinck

  27
  Citations