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Chemistry

D-Index
65
Citations
15836
World Ranking
7626
National Ranking
2231

Overview

Alex Avdeef is affiliated with in-ADME Research in the United States. Their research primarily focuses on chemistry and materials science, with a significant emphasis on subfields such as materials chemistry, spectroscopy, computational theory and mathematics, pharmaceutical science, and filtration and separation.

Their main areas of work encompass analytical chemistry and chromatography, crystallization and solubility studies, computational drug discovery methods, drug solubility and delivery systems, chemical and physical properties in aqueous solutions, pharmacogenetics and drug metabolism, and drug transport and resistance mechanisms.

Alex Avdeef has published extensively in several scientific journals, frequently contributing to:

  • ADMET & DMPK
  • Molecular Pharmaceutics
  • Journal of Solution Chemistry
  • European Journal of Pharmaceutical Sciences
  • Pharmaceutics

Significant recent publications by Alex Avdeef include:

  • Prediction of aqueous intrinsic solubility of druglike molecules using Random Forest regression trained with Wiki-pS0 database, 2020, ADMET & DMPK
  • Predicting Solubility of Newly-Approved Drugs (2016-2020) with a Simple ABSOLV and GSE(Flexible-Acceptor) Consensus Model Outperforming Random Forest Regression, 2022, Journal of Solution Chemistry
  • "Flexible-Acceptor" General Solubility Equation for beyond Rule of 5 Drugs, 2020, Molecular Pharmaceutics

Other notable papers relevant to their research context include:

  • The Critical Role of Passive Permeability in Designing Successful Drugs, 2020, ChemMedChem
  • Findings of the Second Challenge to Predict Aqueous Solubility, 2020, Journal of Chemical Information and Modeling

Frequent collaborators with Alex Avdeef are:

  • Manfred Kansy
  • Abu T.M. Serajuddin
  • Tatjana Ž. Verbić
  • Kiyohiko Sugano
  • Hari P Kandagatla

Best Publications

  • Absorption and Drug Development: Solubility, Permeability, and Charge State

    Alex Avdeef

  • Physicochemical Profiling (Solubility, Permeability and Charge State)

    Alex Avdeef

  • Coexistence of passive and carrier-mediated processes in drug transport

    Kiyohiko Sugano;Manfred Kansy;Per Artursson;Alex Avdeef

  • pH-metric logP 10. Determination of liposomal membrane-water partition coefficients of ionizable drugs.

    A. Avdeef;K. J. Box;J. E. A. Comer;C. Hibbert

  • Coordination chemistry of microbial iron transport compounds. 9. Stability constants for catechol models of enterobactin

    Alex Avdeef;Stephen R. Sofen;Thomas L. Bregante;Kenneth N. Raymond

  • Coordination chemistry of microbial iron transport compounds. 19. Stability constants and electrochemical behavior of ferric enterobactin and model complexes

    Wesley R. Harris;Carl J. Carrano;Stephen R. Cooper;Stephen R. Sofen

  • Absorption and drug development

    Alex Avdeef

  • pH-metric solubility. 2: correlation between the acid-base titration and the saturation shake-flask solubility-pH methods.

    Alex Avdeef;Cynthia M. Berger;Charles Brownell

  • Solubility of sparingly-soluble ionizable drugs.

    Alex Avdeef

  • Absorption Classification of Oral Drugs Based on Molecular Surface Properties

    Christel A S Bergström;Melissa Strafford;Lucia Lazorova;Alex Avdeef

  • PH-metric log P 11. pKa determination of water-insoluble drugs in organic solvent-water mixtures.

    A Avdeef;K.J Box;J.E.A Comer;M Gilges

  • pH-Metric log P. 3. Glass electrode calibration in methanol-water, applied to pKa determination of water-insoluble substances

    Alex Avdeef;John E. A. Comer;Simon J. Thomson

  • Classification analysis of P-glycoprotein substrate specificity.

    Remigijus Didziapetris;Pranas Japertas;Alex Avdeef;Alanas Petrauskas

  • pH-Metric log P. II: Refinement of Partition Coefficients and Ionization Constants of Multiprotic Substances

    Alex Avdeef

  • PAMPA--critical factors for better predictions of absorption.

    Alex Avdeef;Stefanie Bendels;L.i. Di;Bernard Faller

  • The rise of PAMPA.

    Alex Avdeef

  • PAMPA-a drug absorption in vitro model 7. Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones

    Marival Bermejo;Alex Avdeef;Ana Ruiz;Ricardo Nalda

  • Caco-2 permeability of weakly basic drugs predicted with the double-sink PAMPA pKa(flux) method.

    Alex Avdeef;Per Artursson;Sibylle Neuhoff;Sibylle Neuhoff;Lucia Lazorova

  • pH‐Metric log P. Part 1. Difference Plots for Determining Ion‐Pair Octanol‐Water Partition Coefficients of Multiprotic Substances

    Alex Avdeef

  • Skin-PAMPA: a new method for fast prediction of skin penetration.

    Bálint Sinkó;Teresa M. Garrigues;György T. Balogh;Zsombor K. Nagy

  • COORDINATION CHEMISTRY OF MICROBIAL IRON TRANSPORT COMPOUNDS. 19. STABILITY CONSTANTS AND ELECTROCHEMICAL BEHAVIOR OF FERRIC ENTEROBACTIN AND MODEL COMPLEXES

    W. R. Harris;C. J. Carrano;S. R. Cooper;S. R. Soden

Frequent Co-Authors

Per Artursson
Per Artursson Uppsala University
Kenneth N. Raymond
Kenneth N. Raymond Lawrence Berkeley National Laboratory
Li Di
Li Di Pfizer (United States)
Elisabeth Bosch
Elisabeth Bosch University of Barcelona
John P. Fackler
John P. Fackler Texas A&M University
Hans Lennernäs
Hans Lennernäs Uppsala University
Keith O. Hodgson
Keith O. Hodgson Stanford University
Carl J. Carrano
Carl J. Carrano San Diego State University
Allan Zalkin
Allan Zalkin University of California, Berkeley
J. Brian Houston
J. Brian Houston University of Manchester

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