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D-Index & Metrics

Immunology

D-Index
57
Citations
13414
World Ranking
3598
National Ranking
1667

Overview

Anne I. Sperling is affiliated with the University of Virginia in the United States. Their research spans multiple fields, primarily focusing on medicine and immunology and microbiology.

The main fields of study in which they have contributed include:

  • Medicine
  • Immunology and Microbiology

More specifically, their work falls into several subfields, which include:

  • Immunology
  • Pulmonary and Respiratory Medicine
  • Physiology
  • Infectious Diseases
  • Molecular Biology

The primary topics covered in their body of work are:

  • Asthma and respiratory diseases
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • IL-33, ST2, and ILC Pathways
  • Immune Cell Function and Interaction
  • Pediatric health and respiratory diseases
  • COVID-19 Clinical Research Studies
  • Inhalation and Respiratory Drug Delivery

Anne I. Sperling has published research in a variety of venues. The most frequent publication venues include:

  • The Journal of Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • American Journal of Respiratory Cell and Molecular Biology
  • Nature Communications
  • American Journal of Respiratory and Critical Care Medicine

Some representative recent papers illustrating their research focus include:

  • "Modeling human adaptive immune responses with tonsil organoids" (2021), published in Nature Medicine
  • "Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization" (2020), published in Nature Communications
  • "Circulating Plasma Biomarkers of Survival in Antifibrotic-Treated Patients With Idiopathic Pulmonary Fibrosis" (2020), published in CHEST Journal
  • "Hypersensitivity pneumonitis: Current concepts in pathogenesis, diagnosis, and treatment" (2021), published in Allergy
  • "Temperature Trajectory Subphenotypes Correlate With Immune Responses in Patients With Sepsis" (2020), published in Critical Care Medicine

Their frequent co-authors include:

  • Maile K. Hollinger
  • Robert D. Guzy
  • Ayodeji Adegunsoye
  • Mary E. Strek
  • Cara L. Hrusch

Best Publications

  • Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity

    Miranda L. Broz;Mikhail Binnewies;Bijan Boldajipour;Amanda E. Nelson

  • Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.

    Paul Andrew Reyfman;James McCauley Walter;Nikita Joshi;Kishore R. Anekalla

  • Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children

    Michelle M. Stein;Cara L. Hrusch;Justyna Gozdz;Justyna Gozdz;Catherine Igartua

  • Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity.

    Unknown

  • Absence of B7-dependent responses in CD28-deficient mice.

    Jonathan M. Green;Patricia J. Noel;Anne I. Sperling;Theresa L. Walunas

  • Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation.

    Jesse W. Williams;Melissa Y. Tjota;Bryan S. Clay;Bryan Vander Lugt

  • Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen.

    Deborah J. Lenschow;Anne I. Sperling;Michael P. Cooke;Gordon Freeman

  • CD28 costimulation promotes the production of Th2 cytokines.

    I C Rulifson;A I Sperling;P E Fields;F W Fitch

  • ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse.

    Eric J. Allenspach;Patrick Cullinan;Jiankun Tong;Qizhi Tang

  • Modeling human adaptive immune responses with tonsil organoids.

    Lisa E. Wagar;Lisa E. Wagar;Ameen Salahudeen;Ameen Salahudeen;Christian M. Constantz;Ben S. Wendel

  • CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation.

    Anne I. Sperling;Julie A. Auger;Benjamin D. Ehst;Ingrid C. Rulifson

  • Dynamic migration of γδ intraepithelial lymphocytes requires occludin.

    Karen L. Edelblum;Le Shen;Christopher R. Weber;Amanda M. Marchiando

  • Unique antigen recognition by a herpesvirus-specific TCR-gamma delta cell.

    Roger Sciammas;Raymond M. Johnson;Anne I. Sperling;William Brady

  • The Complexities of T‐Cell Co‐stimulation: CD28 and Beyond

    Anne I. Sperling;Jeffrey A. Bluestone

  • DNA methylation in lung cells is associated with asthma endotypes and genetic risk.

    Jessie Nicodemus-Johnson;Rachel A. Myers;Noburu J. Sakabe;Debora R. Sobreira

  • Inducible costimulator regulates Th2-mediated inflammation, but not Th2 differentiation, in a model of allergic airway disease

    Amanda G. Tesciuba;Sumit Subudhi;Russell P. Rother;Susan J. Faas

  • Corticosteroid therapy and airflow obstruction influence the bronchial microbiome, which is distinct from that of bronchoalveolar lavage in asthmatic airways.

    Darcy R. Denner;Naseer Sangwan;Julia B. Becker;D. Kyle Hogarth

  • Cutting Edge: TCR Signaling Induces Selective Exclusion of CD43 from the T Cell-Antigen-Presenting Cell Contact Site

    Anne I. Sperling;John R. Sedy;N. Manjunath;Abraham Kupfer

  • CD43 is a murine T cell costimulatory receptor that functions independently of CD28.

    A I Sperling;J M Green;R L Mosley;P L Smith

  • Role of gamma delta T cells in murine collagen-induced arthritis.

    G M Peterman;C Spencer;A I Sperling;J A Bluestone

  • CTLA4Ig Inhibits Airway Eosinophilia and Hyperresponsiveness by Regulating the Development of Th1/Th2 Subsets in a Murine Model of Asthma

    Philip A. Padrid;Mudit Mathur;Xiantang Li;Karin Herrmann

Frequent Co-Authors

Jeffrey A. Bluestone
Jeffrey A. Bluestone University of California, San Francisco
Julian Solway
Julian Solway University of Chicago
Carole Ober
Carole Ober University of Chicago
Steven R. White
Steven R. White University of California, Irvine
Joel V. Weinstock
Joel V. Weinstock Tufts Medical Center
Jack A. Gilbert
Jack A. Gilbert University of California, San Diego
Janis K. Burkhardt
Janis K. Burkhardt University of Pennsylvania
Jerrold R. Turner
Jerrold R. Turner Brigham and Women's Hospital
Craig B. Thompson
Craig B. Thompson Memorial Sloan Kettering Cancer Center
Robert M. Naclerio
Robert M. Naclerio University of Chicago

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