H-Index & Metrics Top Publications

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Biology and Biochemistry H-index 99 Citations 62,281 175 World Ranking 704 National Ranking 447

Research.com Recognitions

Awards & Achievements

1995 - Fellow of Alfred P. Sloan Foundation

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Neuron

His primary scientific interests are in Nitric oxide, Nitric oxide synthase, Biochemistry, Cell biology and PDZ domain. His Nitric oxide research includes themes of Calmodulin, Enzyme and Central nervous system. His studies in Nitric oxide synthase integrate themes in fields like Myenteric plexus, Molecular biology, Endothelium and Reductase.

His research in the fields of Arginine, Citrulline and Syntrophin overlaps with other disciplines such as Neurotoxicity. His study in Cell biology is interdisciplinary in nature, drawing from both Skeletal muscle, AMPA receptor, Membrane protein and Transmembrane protein. He has researched PDZ domain in several fields, including Biophysics, Disks Large Homolog 4 Protein, Postsynaptic density, Receptor and Membrane-associated guanylate kinase.

His most cited work include:

  • Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. (3032 citations)
  • Localization of nitric oxide synthase indicating a neural role for nitric oxide (2696 citations)
  • Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. (2181 citations)

What are the main themes of his work throughout his whole career to date?

David S. Bredt mainly investigates Cell biology, Nitric oxide synthase, Nitric oxide, Biochemistry and PDZ domain. His Cell biology study combines topics from a wide range of disciplines, such as Postsynaptic potential, Postsynaptic density, Membrane protein, Guanylate kinase and AMPA receptor. His AMPA receptor research focuses on subjects like Synaptic plasticity, which are linked to Neuroscience, Silent synapse and Long-term potentiation.

David S. Bredt has included themes like Myocyte and Skeletal muscle in his Nitric oxide synthase study. David S. Bredt combines subjects such as Molecular biology, Arginine and Calmodulin, Enzyme with his study of Nitric oxide. His study in PDZ domain is interdisciplinary in nature, drawing from both Plasma protein binding, Bioinformatics, Receptor, Membrane-associated guanylate kinase and Disks Large Homolog 4 Protein.

He most often published in these fields:

  • Cell biology (46.15%)
  • Nitric oxide synthase (34.91%)
  • Nitric oxide (33.14%)

What were the highlights of his more recent work (between 2001-2016)?

  • Cell biology (46.15%)
  • AMPA receptor (11.24%)
  • Neuroscience (16.57%)

In recent papers he was focusing on the following fields of study:

Cell biology, AMPA receptor, Neuroscience, Synaptic plasticity and Postsynaptic density are his primary areas of study. David S. Bredt has researched Cell biology in several fields, including Synapse, Biochemistry and Guanylate kinase. His work carried out in the field of Biochemistry brings together such families of science as CASK and Nitric oxide.

His Nitric oxide study integrates concerns from other disciplines, such as Amino acid, Endogenous mediator and Enzyme. His research in Neuroscience intersects with topics in Glutamate receptor, Hyperalgesia and Silent synapse. His work investigates the relationship between Glutamate receptor and topics such as Signal transduction that intersect with problems in Nitric oxide synthase.

Between 2001 and 2016, his most popular works were:

  • AMPA Receptor Trafficking at Excitatory Synapses (976 citations)
  • Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number (600 citations)
  • Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins (435 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Internal medicine

His primary areas of investigation include AMPA receptor, Synaptic plasticity, Cell biology, Neuroscience and Long-term potentiation. In AMPA receptor, David S. Bredt works on issues like Transmembrane protein, which are connected to Membrane protein, Electrophysiology, Gating, Regulation of gene expression and Plasma protein binding. His Cell biology research incorporates themes from Neurotransmission and Postsynaptic density.

His Postsynaptic density study frequently draws connections between related disciplines such as PDZ domain. His Neuroscience research incorporates elements of Metaplasticity and Silent synapse. His study focuses on the intersection of Long-term potentiation and fields such as Protein phosphorylation with connections in the field of Ca2+/calmodulin-dependent protein kinase and Postsynaptic potential.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Top Publications

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

David S. Bredt;Solomon H. Snyder.
Proceedings of the National Academy of Sciences of the United States of America (1990)

4401 Citations

Localization of nitric oxide synthase indicating a neural role for nitric oxide

David S. Bredt;Paul M. Hwang;Solomon H. Snyder.
Nature (1990)

3594 Citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase.

David S. Bredt;Paul M. Hwang;Charles E. Glatt;Charles Lowenstein.
Nature (1991)

3049 Citations

Nitric oxide: a physiologic messenger molecule.

D. S. Bredt;Solomon H Snyder.
Annual Review of Biochemistry (1994)

2925 Citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

Valina L. Dawson;Ted M. Dawson;Edythe D. London;David S. Bredt.
Proceedings of the National Academy of Sciences of the United States of America (1991)

2759 Citations

Nitric oxide, a novel neuronal messenger.

David S. Bredt;Solomon H. Snyder.
Neuron (1992)

2436 Citations

Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues.

Ted M. Dawson;David S. Bredt;Majid Fotuhi;Paul M. Hwang.
Proceedings of the National Academy of Sciences of the United States of America (1991)

2351 Citations

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum

David S. Bredt;Solomon H. Snyder.
Proceedings of the National Academy of Sciences of the United States of America (1989)

2331 Citations

Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains

Jay E Brenman;Daniel S Chao;Stephen H Gee;Aaron W McGee.
Cell (1996)

1950 Citations

Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase

David S. Bredt;Charles E. Glatt;Paul M. Hwang;Majid Fotuhi.
Neuron (1991)

1634 Citations

Profile was last updated on December 6th, 2021.
Research.com Ranking is based on data retrieved from the Microsoft Academic Graph (MAG).
The ranking h-index is inferred from publications deemed to belong to the considered discipline.

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