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D-Index & Metrics

Biology and Biochemistry

D-Index
124
Citations
87610
World Ranking
519
National Ranking
324

Research.com Recognitions

  • 1995 - Fellow of Alfred P. Sloan Foundation

Overview

David S. Bredt is affiliated with Johnson & Johnson in the United States. Their research primarily falls within the domain of Biochemistry, Genetics, and Molecular Biology, with a total of 19 publications in this broad field. Within this area, Bredt's subfield expertise includes Molecular Biology, Computational Theory and Mathematics, Pharmacology, Radiology, Nuclear Medicine and Imaging, and Insect Science.

Their scientific work centers on several main topics, including:

  • Nicotinic Acetylcholine Receptors Study
  • Ion channel regulation and function
  • Receptor Mechanisms and Signaling
  • Computational Drug Discovery Methods
  • Microbial Natural Products and Biosynthesis
  • Phytochemical compounds biological activities
  • Monoclonal and Polyclonal Antibodies Research

Bredt's frequent publication venues include:

  • Nature Reviews Drug Discovery
  • Science
  • Phytomedicine
  • Nature Communications
  • Proceedings of the National Academy of Sciences

Recent papers authored or coauthored by David S. Bredt showcase a focus on drug discovery and receptor biology, including:

  • "Natural products in drug discovery: advances and opportunities" (2021, Nature Reviews Drug Discovery)
  • "Targeting receptor complexes: a new dimension in drug discovery" (2020, Nature Reviews Drug Discovery)
  • "Nicotinic acetylcholine receptor redux: Discovery of accessories opens therapeutic vistas" (2021, Science)
  • "The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis" (2022, Phytomedicine)
  • "Polyamine regulation of ion channel assembly and implications for nicotinic acetylcholine receptor pharmacology" (2020, Nature Communications)

Their frequent coauthors include José A. Matta, Shenyan Gu, Madhurima Dhara, Daniel Knowland, and İlkay Erdoğan Orhan.

David S. Bredt was awarded the title of Fellow of the Alfred P. Sloan Foundation in 1995.

Best Publications

  • Natural products in drug discovery: advances and opportunities.

    Atanas G Atanasov;Sergey B Zotchev;Verena M Dirsch

  • Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

    David S. Bredt;Solomon H. Snyder

  • Localization of nitric oxide synthase indicating a neural role for nitric oxide

    David S. Bredt;Paul M. Hwang;Solomon H. Snyder

  • Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase.

    David S. Bredt;Paul M. Hwang;Charles E. Glatt;Charles Lowenstein

  • Nitric oxide: a physiologic messenger molecule.

    D. S. Bredt;Solomon H Snyder

  • Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

    Valina L. Dawson;Ted M. Dawson;Edythe D. London;David S. Bredt

  • Nitric oxide, a novel neuronal messenger.

    David S. Bredt;Solomon H. Snyder

  • Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues.

    Ted M. Dawson;David S. Bredt;Majid Fotuhi;Paul M. Hwang

  • Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum

    David S. Bredt;Solomon H. Snyder

  • Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains

    Jay E Brenman;Daniel S Chao;Stephen H Gee;Aaron W McGee

  • Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase

    David S. Bredt;Charles E. Glatt;Paul M. Hwang;Majid Fotuhi

  • Targeted disruption of the neuronal nitric oxide synthase gene

    Paul L. Huang;Ted M. Dawson;David S. Bredt;Solomon H. Snyder

  • Nitric oxide: a physiologic mediator of penile erection

    Arthur L. Burnett;Charles J. Lowenstein;David S. Bredt;Thomas S. K. Chang

  • AMPA Receptor Trafficking at Excitatory Synapses

    David S Bredt;Roger A Nicoll

  • Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms

    Lu Chen;Dane M. Chetkovich;Ronald S. Petralia;Neal T. Sweeney

  • Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy.

    Jay E. Brenman;Daniel S. Chao;Houhui Xia;Kenneth D Aldape

  • Nitric oxide in skeletal muscle

    Lester Kobzik;Michael B. Reid;David S. Bredt;Jonathan S. Stamler

  • Biological Roles of Nitric Oxide

    Solomon H. Snyder;David S. Bredt

  • Endogenous nitric oxide synthesis: Biological functions and pathophysiology

    David S. Bredt

  • Generation of superoxide by purified brain nitric oxide synthase.

    S Pou;W S Pou;D S Bredt;S H Snyder

Frequent Co-Authors

Solomon H. Snyder
Solomon H. Snyder Johns Hopkins University School of Medicine
Roger A. Nicoll
Roger A. Nicoll University of California, San Francisco
Ted M. Dawson
Ted M. Dawson Johns Hopkins University School of Medicine
Paul M. Hwang
Paul M. Hwang National Institutes of Health
Masaki Fukata
Masaki Fukata The Graduate University for Advanced Studies, SOKENDAI
Yuko Fukata
Yuko Fukata National Institutes of Natural Sciences
Yuan Xiang Tao
Yuan Xiang Tao Rutgers, The State University of New Jersey
Chiye Aoki
Chiye Aoki New York University
Ronald S. Petralia
Ronald S. Petralia National Institutes of Health
Charles J. Lowenstein
Charles J. Lowenstein Johns Hopkins University School of Medicine

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