World's Best Scientists 2026 revealed!
Immanuel F. Luescher

Immanuel F. Luescher

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
10999
World Ranking
16096
National Ranking
305

Overview

Immanuel F. Luescher is affiliated with the University of Lausanne in Switzerland. Their research focuses primarily on the fields of Medicine and Immunology and Microbiology, with significant contributions to specialized subfields such as Immunology, Oncology, Molecular Biology, and Dermatology.

The scientist has authored several recent papers addressing various aspects of immune cell function and immunotherapy. These works include:

  • CD8 T cell function and cross-reactivity explored by stepwise increased peptide-HLA versus TCR affinity, 2022, Frontiers in Immunology
  • Probing the Conformational Dynamics of Affinity-Enhanced T Cell Receptor Variants upon Binding the Peptide-Bound Major Histocompatibility Complex by Hydrogen/Deuterium Exchange Mass Spectrometry, 2021, Biochemistry
  • PD-1 and Tim-3 Regulate the Expansion of Tumor Antigen-Specific CD8+ T Cells Induced by Melanoma Vaccines, 2020, UNC Libraries
  • Toward Sézary Syndrome immunotherapy, 2021, The Journal of Immunology

Luescher's research addresses significant topics including CAR-T cell therapy research, Immunotherapy and Immune Responses, vaccines and immunoinformatics approaches, Immune Cell Function and Interaction, T-cell and B-cell Immunology, Toxin Mechanisms and Immunotoxins, and Peptidase Inhibition and Analysis.

The frequent co-authors collaborating with this researcher include Philippe Guillaume, Petra Baumgaertner, Julien Schmidt, Carla-Marisa Costa-Nunes, and Natacha Bordry. This collaboration network reflects interdisciplinary work crossing immunology and molecular techniques.

Their findings have been published in multiple venues such as Frontiers in Immunology, Biochemistry, UNC Libraries, and The Journal of Immunology, indicating engagement with diverse academic platforms within the immunological and biomedical research communities.

Best Publications

  • Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patients

    Julien Fourcade;Zhaojun Sun;Mourad Benallaoua;Philippe Guillaume

  • A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by cytolytic T lymphocytes directed against tumor antigen MZ2-E.

    C Traversari;P van der Bruggen;I F Luescher;C Lurquin

  • CD8+ T Cells Specific for Tumor Antigens Can Be Rendered Dysfunctional by the Tumor Microenvironment through Upregulation of the Inhibitory Receptors BTLA and PD-1

    Julien Fourcade;Zhaojun Sun;Ornella Pagliano;Philippe Guillaume

  • Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

    Alexis M. Kalergis;Nicole Boucheron;Marie-Agnés Doucey;Edith Palmieri

  • T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion

    Daniel T Utzschneider;Amandine Legat;Silvia A Fuertes Marraco;Lucie Carrié

  • Full activation of the T cell receptor requires both clustering and conformational changes at CD3.

    Susana Minguet;Mahima Swamy;Balbino Alarcón;Immanuel F. Luescher

  • CD8 modulation of T-cell antigen receptor-ligand interactions on living cytotoxic T lymphocytes.

    Immanuel F. Luescher;Eric Vivier;Andréas Layer;Jérôme Mahiou

  • CD8beta endows CD8 with efficient coreceptor function by coupling T cell receptor/CD3 to raft-associated CD8/p56(lck) complexes.

    Alexandre Arcaro;Claude Grégoire;Talitha R. Bakker;Lucia Baldi

  • Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes.

    Nathalie Demotte;Nathalie Demotte;Vincent Stroobant;Vincent Stroobant;Pierre J. Courtoy;Patrick Van Der Smissen

  • PD-1 and Tim-3 Regulate the Expansion of Tumor Antigen–Specific CD8+ T Cells Induced by Melanoma Vaccines

    Julien Fourcade;Zhaojun Sun;Ornella Pagliano;Joe Marc Chauvin

  • Essential role of CD8 palmitoylation in CD8 coreceptor function.

    Alexandre Arcaro;Claude Grégoire;Nicole Boucheron;Sabine Stotz

  • Cis association of Ly49A with MHC class I restricts natural killer cell inhibition.

    Marie-Agnès Doucey;Léonardo Scarpellino;Jacques Zimmer;Philippe Guillaume

  • PD-1 Is a Regulator of NY-ESO-1-Specific CD8+ T Cell Expansion in Melanoma Patients

    Julien Fourcade;Pavol Kudela;Zhaojun Sun;Hongmei Shen

  • H-2Kd-restricted antigenic peptides share a simple binding motif.

    P Romero;G Corradin;I F Luescher;J L Maryanski

  • Antigenicity and immunogenicity of Melan-A/MART-1 derived peptides as targets for tumor reactive CTL in human melanoma.

    Pedro Romero;Danila Valmori;Mikael J. Pittet;Alfred Zippelius

  • Interplay between T Cell Receptor Binding Kinetics and the Level of Cognate Peptide Presented by Major Histocompatibility Complexes Governs CD8+ T Cell Responsiveness

    Melita Irving;Vincent Zoete;Michael Hebeisen;Daphné Schmid

  • Cholesterol and Sphingomyelin Drive Ligand-independent T-cell Antigen Receptor Nanoclustering

    Eszter Molnár;Eszter Molnár;Mahima Swamy;Mahima Swamy;Martin Holzer;Katharina Beck-García

  • A peptide encoded by the human MAGE3 gene and presented by HLA-B44 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE3.

    Jean Herman;Pierre van der Bruggen;Immanuel F Luescher;Susanna Mandruzzato

  • CD3δ Establishes a Functional Link between the T Cell Receptor and CD8

    Marie-Agnès Doucey;Laurence Goffin;Dieter Naeher;Olivier Michielin

  • The Efficiency of Antigen Recognition by CD8+ CTL Clones Is Determined by the Frequency of Serial TCR Engagement

    Denis Hudrisier;Benedikt Kessler;Salvatore Valitutti;Clotilde Horvath

Frequent Co-Authors

Philippe Guillaume
Philippe Guillaume University of Lausanne
Jean-Charles Cerottini
Jean-Charles Cerottini University of Lausanne
Pedro Romero
Pedro Romero University of Lausanne
Daniel E. Speiser
Daniel E. Speiser University of Lausanne
Olivier Michielin
Olivier Michielin University of Lausanne
Nathalie Rufer
Nathalie Rufer University Hospital of Lausanne
John M. Kirkwood
John M. Kirkwood University of Pittsburgh
Bernard Malissen
Bernard Malissen Aix-Marseille University
Vijay K. Kuchroo
Vijay K. Kuchroo Harvard University
Lloyd J. Old
Lloyd J. Old Ludwig Cancer Research

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Students interested in Biology and Biochemistry have a wide range of online degree and career options in the healthcare and science fields. Many professionals continue their education to specialize in administration, advanced research, or clinical leadership.

For those looking into healthcare leadership, top cahme-accredited mha programs ensure quality training in healthcare administration and management. Similarly, if you are aiming for clinical nursing leadership roles, you might consider online dnp programs without clinicals to advance your expertise without the need for in-person practicums.

Leadership roles beyond the master's level can be explored through doctoral programs for healthcare administration, which are ideal for those seeking executive or academic positions. Similarly, if you have a background in biochemistry and want to move into pharmacy, online pharmd programs for non pharmacists offer an accelerated path into this rewarding profession.

Each of these pathways offers flexibility through online learning, making it easier to balance your studies with work or personal commitments while advancing your career in science and healthcare.

Best Scientists Citing Immanuel F. Luescher

Trending Scientists