D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 52 Citations 10,018 153 World Ranking 12044 National Ranking 226

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Immune system
  • Antigen

His primary areas of study are Antigen, CD8, Cytotoxic T cell, T cell and T-cell receptor. His Antigen research integrates issues from Tumor antigen and Peptide. His CD8 study is focused on Immunology in general.

His studies examine the connections between Cytotoxic T cell and genetics, as well as such issues in Cancer research, with regards to Tumor microenvironment and BTLA. His work investigates the relationship between T cell and topics such as Cytoplasm that intersect with problems in Phosphorylation, Proto-oncogene tyrosine-protein kinase Src and Phosphatase. Immanuel F. Luescher interconnects Biophysics, Molecular biology, Avidity, Cell biology and CD3 in the investigation of issues within T-cell receptor.

His most cited work include:

  • Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patients (847 citations)
  • A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by cytolytic T lymphocytes directed against tumor antigen MZ2-E. (698 citations)
  • Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex (286 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Cytotoxic T cell, CD8, Molecular biology, T-cell receptor and Major histocompatibility complex. His study in Cytotoxic T cell is interdisciplinary in nature, drawing from both Cancer research and Immunology. His work deals with themes such as T cell, Cytokine and Cell biology, which intersect with CD8.

His research integrates issues of T lymphocyte, Antigen, MHC class II, Perforin and CTL* in his study of Molecular biology. His T-cell receptor research includes themes of Receptor, Ligand, CD3 and Avidity. His Major histocompatibility complex research is multidisciplinary, incorporating perspectives in Biophysics, Computational biology and Peptide.

He most often published in these fields:

  • Cytotoxic T cell (44.16%)
  • CD8 (40.26%)
  • Molecular biology (39.61%)

What were the highlights of his more recent work (between 2009-2021)?

  • Cytotoxic T cell (44.16%)
  • CD8 (40.26%)
  • Immunology (27.92%)

In recent papers he was focusing on the following fields of study:

Immanuel F. Luescher mainly focuses on Cytotoxic T cell, CD8, Immunology, Antigen and T cell. His research integrates issues of Cancer research, Peptide and Cell biology in his study of Cytotoxic T cell. He has included themes like Ex vivo, Cytokine, Apoptosis, Molecular biology and T-cell receptor in his CD8 study.

As part of one scientific family, Immanuel F. Luescher deals mainly with the area of Immunology, narrowing it down to issues related to the Cellular differentiation, and often Chronic infection and Immunophenotyping. His Antigen research also works with subjects such as

  • Tumor antigen together with Epitope,
  • In silico that connect with fields like Epitope mapping. His T cell research is multidisciplinary, relying on both Chemokine and Cytotoxicity.

Between 2009 and 2021, his most popular works were:

  • Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patients (847 citations)
  • CD8+ T Cells Specific for Tumor Antigens Can Be Rendered Dysfunctional by the Tumor Microenvironment through Upregulation of the Inhibitory Receptors BTLA and PD-1 (244 citations)
  • T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion (170 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Immune system
  • DNA

The scientist’s investigation covers issues in CD8, Cytotoxic T cell, Antigen, Immunology and Molecular biology. His CD8 study incorporates themes from T cell, Adjuvant and Vaccination. His Cytotoxic T cell study is mostly concerned with Antigen-presenting cell and Tumor antigen.

His Antigen study combines topics from a wide range of disciplines, such as Cancer and Immune system. His Immunology research integrates issues from Cancer research and Cellular differentiation. His studies deal with areas such as Chromatin remodeling, Epigenetics, Major histocompatibility complex and T-cell receptor as well as Molecular biology.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patients

Julien Fourcade;Zhaojun Sun;Mourad Benallaoua;Philippe Guillaume.
Journal of Experimental Medicine (2010)

1233 Citations

A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by cytolytic T lymphocytes directed against tumor antigen MZ2-E.

C Traversari;P van der Bruggen;I F Luescher;C Lurquin.
Journal of Experimental Medicine (1992)

854 Citations

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

Alexis M. Kalergis;Nicole Boucheron;Marie-Agnés Doucey;Edith Palmieri.
Nature Immunology (2001)

391 Citations

CD8+ T Cells Specific for Tumor Antigens Can Be Rendered Dysfunctional by the Tumor Microenvironment through Upregulation of the Inhibitory Receptors BTLA and PD-1

Julien Fourcade;Zhaojun Sun;Ornella Pagliano;Philippe Guillaume.
Cancer Research (2012)

371 Citations

CD8 modulation of T-cell antigen receptor-ligand interactions on living cytotoxic T lymphocytes.

Immanuel F. Luescher;Eric Vivier;Andréas Layer;Jérôme Mahiou.
Nature (1995)

302 Citations

T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion

Daniel T Utzschneider;Amandine Legat;Silvia A Fuertes Marraco;Lucie Carrié.
Nature Immunology (2013)

273 Citations

Full activation of the T cell receptor requires both clustering and conformational changes at CD3.

Susana Minguet;Mahima Swamy;Balbino Alarcón;Immanuel F. Luescher.
Immunity (2007)

271 Citations

CD8beta endows CD8 with efficient coreceptor function by coupling T cell receptor/CD3 to raft-associated CD8/p56(lck) complexes.

Alexandre Arcaro;Claude Grégoire;Talitha R. Bakker;Lucia Baldi.
Journal of Experimental Medicine (2001)

251 Citations

Cis association of Ly49A with MHC class I restricts natural killer cell inhibition.

Marie-Agnès Doucey;Léonardo Scarpellino;Jacques Zimmer;Philippe Guillaume.
Nature Immunology (2004)

233 Citations

Essential role of CD8 palmitoylation in CD8 coreceptor function.

Alexandre Arcaro;Claude Grégoire;Nicole Boucheron;Sabine Stotz.
Journal of Immunology (2000)

231 Citations

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