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Philippe Guillaume

Philippe Guillaume

D-Index & Metrics

Immunology

D-Index
62
Citations
11583
World Ranking
3167
National Ranking
77

Overview

Philippe Guillaume is affiliated with Ludwig Cancer Research in Belgium, contributing extensively to the fields of medicine, immunology, microbiology, and molecular biology. Their research primarily centers on immunotherapy and immune responses, CAR-T cell therapy, vaccines and immunoinformatics approaches, T-cell and B-cell immunology, cancer immunotherapy and biomarkers, immune cell function and interaction, as well as single-cell and spatial transcriptomics.

Their recent publications include:

  • "Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer," 2021, Science Advances
  • "Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes," 2023, Immunity
  • "Sensitive identification of neoantigens and cognate TCRs in human solid tumors," 2021, Nature Biotechnology
  • "Improved predictions of antigen presentation and TCR recognition with MixMHCpred2.2 and PRIME2.0 reveal potent SARS-CoV-2 CD8+ T-cell epitopes," 2023, Cell Systems
  • "Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors," 2023, Nature Communications

Guillaume frequently publishes in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science Advances
  • Frontiers in Immunology
  • Journal for ImmunoTherapy of Cancer
  • iScience

The scientist collaborates regularly with a core group of co-authors, including:

  • Julien Schmidt
  • Alexandre Harari
  • David Gfeller
  • George Coukos
  • Raphaël Genolet

Their work covers several key areas within medicine and biology, with a focus on immunology and oncology. The subfields relevant to their research include immunology, oncology, molecular biology, psychiatry and mental health, and genetics.

Philippe Guillaume's investigations often explore core topics such as immunotherapy and immune responses, advancing CAR-T cell therapy research, and developing vaccines and immunoinformatics approaches. Their research also involves studying T-cell and B-cell immunology, identifying cancer immunotherapy biomarkers, analyzing immune cell function and interaction, and utilizing single-cell and spatial transcriptomics methodologies.

Best Publications

  • Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patients

    Julien Fourcade;Zhaojun Sun;Mourad Benallaoua;Philippe Guillaume

  • Effector Function of Human Tumor-Specific CD8 T Cells in Melanoma Lesions: A State of Local Functional Tolerance

    Alfred Zippelius;Pascal Batard;Verena Rubio-Godoy;Gilles Bioley

  • CD8+ T Cells Specific for Tumor Antigens Can Be Rendered Dysfunctional by the Tumor Microenvironment through Upregulation of the Inhibitory Receptors BTLA and PD-1

    Julien Fourcade;Zhaojun Sun;Ornella Pagliano;Philippe Guillaume

  • Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer

    Amélie Cachot;Mariia Bilous;Mariia Bilous;Yen-Cheng Liu;Xiaokang Li

  • Deciphering HLA-I motifs across HLA peptidomes improves neo-antigen predictions and identifies allostery regulating HLA specificity.

    Michal Bassani-Sternberg;Chloé Chong;Chloé Chong;Philippe Guillaume;Philippe Guillaume;Marthe Solleder;Marthe Solleder

  • Robust prediction of HLA class II epitopes by deep motif deconvolution of immunopeptidomes.

    Julien Racle;Justine Michaux;Georg Alexander Rockinger;Marion Arnaud

  • RHAMM-R3 peptide vaccination in patients with acute myeloid leukemia, myelodysplastic syndrome, and multiple myeloma elicits immunologic and clinical responses.

    Michael Schmitt;Anita Schmitt;Markus T. Rojewski;Jinfei Chen

  • PD-1 and Tim-3 Regulate the Expansion of Tumor Antigen–Specific CD8+ T Cells Induced by Melanoma Vaccines

    Julien Fourcade;Zhaojun Sun;Ornella Pagliano;Joe Marc Chauvin

  • Cis association of Ly49A with MHC class I restricts natural killer cell inhibition.

    Marie-Agnès Doucey;Léonardo Scarpellino;Jacques Zimmer;Philippe Guillaume

  • PD-1 Is a Regulator of NY-ESO-1-Specific CD8+ T Cell Expansion in Melanoma Patients

    Julien Fourcade;Pavol Kudela;Zhaojun Sun;Hongmei Shen

  • CpG Are Efficient Adjuvants for Specific CTL Induction Against Tumor Antigen-Derived Peptide

    Isabelle Miconnet;Sylvain Koenig;Daniel Speiser;Arthur Krieg;Arthur Krieg

  • Antigenicity and immunogenicity of Melan-A/MART-1 derived peptides as targets for tumor reactive CTL in human melanoma.

    Pedro Romero;Danila Valmori;Mikael J. Pittet;Alfred Zippelius

  • Thymic selection generates a large T cell pool recognizing a self-peptide in humans.

    Alfred Zippelius;Mikaël J. Pittet;Pascal Batard;Nathalie Rufer

  • Cooperation of human tumor-reactive CD4 + and CD8 + T cells after redirection of their specificity by a high-affinity p53A2.1-specific TCR

    Jürgen Kuball;Frank W. Schmitz;Ralf Holger Voss;Edite Antunes Ferreira

  • New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site.

    Victor Appay;Camilla Jandus;Verena Voelter;Severine Reynard

  • In vivo administration of a lentiviral vaccine targets DCs and induces efficient CD8 + T cell responses

    Christoph Esslinger;Laurence Chapatte;Daniela Finke;Isabelle Miconnet

  • Mutated regions of nucleophosmin 1 elicit both CD4+ and CD8+ T-cell responses in patients with acute myeloid leukemia

    Jochen Greiner;Yoko Ono;Yoko Ono;Susanne Hofmann;Anita Schmitt;Anita Schmitt

  • High vaccination efficiency of low-affinity epitopes in antitumor immunotherapy

    David-Alexandre Gross;Stéphanie Graff-Dubois;Paule Opolon;Sébastien Cornet

  • The Length Distribution and Multiple Specificity of Naturally Presented HLA-I Ligands.

    David Gfeller;David Gfeller;Philippe Guillaume;Justine Michaux;Hui-Song Pak

  • Interplay between T Cell Receptor Binding Kinetics and the Level of Cognate Peptide Presented by Major Histocompatibility Complexes Governs CD8+ T Cell Responsiveness

    Melita Irving;Vincent Zoete;Michael Hebeisen;Daphné Schmid

  • Proteasome-assisted identification of a SSX-2-derived epitope recognized by tumor-reactive CTL infiltrating metastatic melanoma.

    Maha Ayyoub;Stefan Stevanovic;Ugur Sahin;Philippe Guillaume

Frequent Co-Authors

Immanuel F. Luescher
Immanuel F. Luescher University of Lausanne
Pedro Romero
Pedro Romero University of Lausanne
Daniel E. Speiser
Daniel E. Speiser University of Lausanne
Jean-Charles Cerottini
Jean-Charles Cerottini University of Lausanne
Danila Valmori
Danila Valmori University of Nantes
David Gfeller
David Gfeller University of Lausanne
George Coukos
George Coukos Cornell University
Mikael J. Pittet
Mikael J. Pittet University of Geneva
Nathalie Rufer
Nathalie Rufer University Hospital of Lausanne
Olivier Michielin
Olivier Michielin University of Lausanne

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