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Wolfgang W. A. Schamel

Wolfgang W. A. Schamel

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
9193
World Ranking
16254
National Ranking
1141

Overview

Wolfgang W. A. Schamel is affiliated with the University of Freiburg in Germany. Their research spans multiple fields including Immunology and Microbiology, Medicine, and Biochemistry, Genetics and Molecular Biology. The scientist's subfields of study include Immunology, Molecular Biology, Oncology, Biomedical Engineering, and Biotechnology.

Their work primarily focuses on immune cell function and interaction, T-cell and B-cell immunology, and CAR-T cell therapy research. Additional topics covered in their research include nanowire synthesis and applications, monoclonal and polyclonal antibodies research, transgenic plants and applications, as well as viral infectious diseases and gene expression in insects.

Recent significant publications include:

  • Molecular mechanism of SHP2 activation by PD-1 stimulation, 2020, Science Advances
  • Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity, 2023, Cancer Cell
  • αβ and γδ T cell receptors: Similar but different, 2020, Journal of Leukocyte Biology
  • Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function, 2020, Nature Immunology
  • Harnessing CD3 diversity to optimize CAR T cells, 2023, Nature Immunology

Frequent collaborators in their research include Susana Minguet, O. Sascha Yousefi, Claudia Juraske, Anna Morath, and Gina J. Fiala.

Their work has been published repeatedly in venues such as bioRxiv (Cold Spring Harbor Laboratory), Frontiers in Immunology, Science Advances, Nature Immunology, and Frontiers in Cell and Developmental Biology.

Best Publications

  • Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop.

    Véronique Rolli;Maike Gallwitz;Thomas Wossning;Alexandra Flemming

  • Monomeric and oligomeric complexes of the B cell antigen receptor.

    Wolfgang W.A Schamel;Michael Reth

  • Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response.

    Wolfgang W.A. Schamel;Ignacio Arechaga;Ruth M. Risueño;Hisse M. van Santen

  • Full activation of the T cell receptor requires both clustering and conformational changes at CD3.

    Susana Minguet;Mahima Swamy;Balbino Alarcón;Immanuel F. Luescher

  • ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis.

    Andrea Maul-Pavicic;Samuel C. C. Chiang;Anne Rensing-Ehl;Birthe Jessen

  • Adenosine and cAMP are potent inhibitors of the NF‐κB pathway downstream of immunoreceptors

    Susanna Minguet;Michael Huber;Lisa Rosenkranz;Wolfgang W. A. Schamel

  • Two-dimensional Blue Native/SDS Gel Electrophoresis of Multi-Protein Complexes from Whole Cellular Lysates A PROTEOMICS APPROACH

    Margarita M. Camacho-Carvajal;Bernd Wollscheid;Ruedi Aebersold;Viktor Steimle

  • A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation

    Mahima Swamy;Mahima Swamy;Mahima Swamy;Katharina Beck-Garcia;Katharina Beck-Garcia;Esmeralda Beck-Garcia;Esmeralda Beck-Garcia;Frederike A. Hartl

  • Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol.

    Feng Wang;Katharina Beck-García;Carina Zorzin;Wolfgang W A Schamel

  • Increased Sensitivity of Antigen-Experienced T Cells through the Enrichment of Oligomeric T Cell Receptor Complexes

    Rashmi Kumar;María Ferez;Mahima Swamy;Ignacio Arechaga

  • Molecular mechanism of SHP2 activation by PD-1 stimulation

    M. Marasco;A. Berteotti;J. Weyershaeuser;N. Thorausch

  • Initiation of TCR signaling: regulation within CD3 dimers.

    Balbino Alarcón;Diana Gil;Pilar Delgado;Wolfgang W. A. Schamel

  • Antiviral and Regulatory T Cell Immunity in a Patient with Stromal Interaction Molecule 1 Deficiency

    Sebastian Fuchs;Anne Rensing-Ehl;Carsten Speckmann;Bertram Bengsch

  • Blue Native Polyacrylamide Gel Electrophoresis (BN-PAGE) for the Identification and Analysis of Multiprotein Complexes

    Mahima Swamy;Gabrielle M. Siegers;Susana Minguet;Bernd Wollscheid

  • Cholesterol and Sphingomyelin Drive Ligand-independent T-cell Antigen Receptor Nanoclustering

    Eszter Molnár;Eszter Molnár;Mahima Swamy;Mahima Swamy;Martin Holzer;Katharina Beck-García

  • Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response

    Patrick A. Baeuerle;Jian Ding;Ekta Patel;Niko Thorausch

  • The specificity of association of the IgD molecule with the accessory proteins BAP31/BAP29 lies in the IgD transmembrane sequence.

    T. Adachi;W. W. A. Schamel;K.-M. Kim;T. Watanabe

  • Red Light-Regulated Reversible Nuclear Localization of Proteins in Mammalian Cells and Zebrafish.

    Hannes M. Beyer;Samuel Juillot;Kathrin Herbst;Sophia L. Samodelov

  • Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling.

    Michael Röring;Ricarda Herr;Gina J Fiala;Gina J Fiala;Katharina Heilmann

  • Comparison of the tamoxifen regulated chimeric Cre recombinases MerCreMer and CreMer.

    Chrysi Verrou;Yong Zhang;Christa Zürn;Wolfgang W.A. Schamel

Frequent Co-Authors

Balbino Alarcón
Balbino Alarcón Spanish National Research Council
Michael Reth
Michael Reth University of Freiburg
Wilfried Weber
Wilfried Weber University of Freiburg
Thomas Höfer
Thomas Höfer German Cancer Research Center
Matias D. Zurbriggen
Matias D. Zurbriggen Heinrich Heine University Düsseldorf
Marina A. Freudenberg
Marina A. Freudenberg University of Freiburg
Burkhart Schraven
Burkhart Schraven Otto-von-Guericke University Magdeburg
Stephan Ehl
Stephan Ehl University of Freiburg
Robert Zeiser
Robert Zeiser University of Freiburg
Michael Huber
Michael Huber University of Zurich

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