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Marina A. Freudenberg

Marina A. Freudenberg

D-Index & Metrics

Microbiology

D-Index
72
Citations
33602
World Ranking
1705
National Ranking
124

Overview

Marina A. Freudenberg is affiliated with the University of Freiburg in Germany. They specialize in research within the fields of immunology and microbiology, as well as biochemistry, genetics, and molecular biology. Their work spans both broad and focused areas, including immunology, cancer research, and genetics.

The primary topics addressed in their research include immune response and inflammation, immune cell function and interaction, NF-κB signaling pathways, virus-based gene therapy research, and interferon and immune responses. This reflects a focus on understanding the mechanisms of immune regulation and signaling, especially in the context of viral infection and inflammatory processes.

Freudenberg has published research in notable scientific venues such as the Proceedings of the National Academy of Sciences and the Journal of Innate Immunity. Their recent papers include:

  • Sulfatides are endogenous ligands for the TLR4-MD-2 complex, 2021, Proceedings of the National Academy of Sciences
  • Type I interferon, induced by adenovirus or adenoviral vector infection, regulates the cytokine response to LPS in a macrophage type-specific manner, 2024, Journal of Innate Immunity

Freudenberg has collaborated frequently with several researchers, including:

  • Bruce Beutler
  • Lijing Su
  • Muhammad Athamna
  • Ying Wang
  • Junmei Wang

Their contributions explore how immune signaling pathways are modulated by endogenous and viral factors, with implications for understanding inflammation and immune cell behavior. The investigation of molecular interactions such as those involving TLR4-MD-2 complexes and the role of type I interferons highlights an interest in innate immunity and cytokine regulation.

Best Publications

  • Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

    Alexander Poltorak;Xiaolong He;Irina Smirnova;Mu Ya Liu

  • Impaired immune and acute-phase responses in interleukin-6-deficient mice

    Manfred Kopf;Heinz Baumann;Giulia Freer;Marina Freudenberg

  • Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4

    Christian C. Termeer;Frauke Benedix;Jonathon Sleeman;Christina Fieber

  • Galactosamine-induced sensitization to the lethal effects of endotoxin.

    Chris Galanos;Marina A. Freudenberg;Werner Reutter

  • CD14 is required for MyD88-independent LPS signaling

    Zhengfan Jiang;Philippe Georgel;Xin Du;Louis Shamel

  • Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice.

    V Lehmann;M A Freudenberg;C Galanos

  • Synthetic and natural Escherichia coli free lipid A express identical endotoxic activities

    Chris Galanos;Otto Lüderitz;Ernst Th. Rietschel;Otto Westphal

  • Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel

    Marc Schmidt;Badrinarayanan Raghavan;Badrinarayanan Raghavan;Verena Müller;Verena Müller;Thomas Vogl

  • Lipopolysaccharides of Gram-Negative Bacteria

    Otto Lüderitz;Marina A. Freudenberg;Chris Galanos;Volker Lehmann

  • Lipopolysaccharide-binding protein is required to combat a murine Gram-negative bacterial infection

    Robert S. Jack;Xiaolong Fan;Martin Bernheiden;Gabriele Rune

  • Requirement for lipopolysaccharide-responsive macrophages in galactosamine-induced sensitization to endotoxin.

    M A Freudenberg;D Keppler;C Galanos

  • Human and Mouse Granzyme A Induce a Proinflammatory Cytokine Response

    Sunil S. Metkar;Cheikh Menaa;Julian Pardo;Julian Pardo;Baikun Wang

  • Modification of the silver staining technique to detect lipopolysaccharide in polyacrylamide gels.

    A Fomsgaard;M A Freudenberg;C Galanos

  • Mechanisms of chemical-induced innate immunity in allergic contact dermatitis.

    S. F. Martin;P. R. Esser;F. C. Weber;F. C. Weber;T. Jakob

  • Induction of tolerance to lipopolysaccharide (LPS)-D-galactosamine lethality by pretreatment with LPS is mediated by macrophages.

    M A Freudenberg;C Galanos

  • Tumor necrosis factor alpha mediates lethal activity of killed gram-negative and gram-positive bacteria in D-galactosamine-treated mice.

    M A Freudenberg;C Galanos

  • Toll-Like Receptor 4 Contributes to Efficient Control of Infection with the Protozoan Parasite Leishmania major

    Pascale Kropf;Marina A. Freudenberg;Manuel Modolell;Helen P. Price

  • Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage

    Lukas Schwab;Luise Goroncy;Senthilnathan Palaniyandi;Sanjivan Gautam

  • Mouse CD8α+ DCs and human BDCA3+ DCs are major producers of IFN-λ in response to poly IC

    Henning Lauterbach;Barbara Bathke;Stefanie Gilles;Claudia Traidl-Hoffmann

  • Mechanisms of endotoxin shock and endotoxin hypersensitivity

    Chris Galanos;Marina A. Freudenberg

Frequent Co-Authors

Chris Galanos
Chris Galanos Max Planck Society
Michael Huber
Michael Huber University of Zurich
Thilo Jakob
Thilo Jakob University of Giessen
Carsten J. Kirschning
Carsten J. Kirschning University of Duisburg-Essen
Ernst Th. Rietschel
Ernst Th. Rietschel Institute for Advanced Sustainability Studies
Hermann Wagner
Hermann Wagner Technical University of Munich
Urs F. Greber
Urs F. Greber University of Zurich
Wolfgang W. A. Schamel
Wolfgang W. A. Schamel University of Freiburg
Anders Fomsgaard
Anders Fomsgaard Statens Serum Institut
Markus M. Heimesaat
Markus M. Heimesaat Charité - University Medicine Berlin

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