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Shoichi Kusumoto

Shoichi Kusumoto

D-Index & Metrics

Biology and Biochemistry

D-Index
80
Citations
25148
World Ranking
4046
National Ranking
263

Overview

Shoichi Kusumoto is affiliated with Osaka University in Japan and has an active research profile spanning molecular biology, oncology, and cancer research. Their work primarily intersects with biochemistry, genetics, and molecular biology, with a notable contribution to medicine.

The scientist's publication record includes papers focused on cancer biology and related molecular mechanisms. Recent publications showcase investigations into ovarian clear cell carcinoma and tumor cell plasticity in endometrioid carcinoma. Key papers include:

  • "An immature inhibin-α-expressing subpopulation of ovarian clear cell carcinoma cells is related to an unfavorable prognosis" (2021), published in Cancer Medicine
  • "Tumor cell plasticity in endometrioid carcinoma is regulated by neuronal membrane glycoprotein M6-b" (2022), published in Oncology Letters
  • "1267P A phase I trial of OPB-111077 in combination with bendamustine and rituximab in relapsed or refractory diffuse large B-cell lymphoma: Results from interim analysis" (2025), published in Annals of Oncology

Their research has a clear emphasis on topics such as TGF-β signaling in diseases, Kruppel-like factors research, and FOXO transcription factor regulation. Further focal points include the study of cancer cells and metastasis, cancer-related hypoxia and metabolism, as well as the interplay of cancer with stress, anesthesia, and immune response.

Frequent co-authors collaborating with Kusumoto include Masako Kurashige, Shinichiro Tahara, Takahiro Matsui, Satoshi Nojima, and Eiichi Morii. This consistent collaboration reflects ongoing partnerships within the scientific community.

Publications have appeared in several venues, predominantly Cancer Medicine, Oncology Letters, and Annals of Oncology. These journals align with Kusumoto's focus areas in cancer and molecular biology research.

Within the subfields, Kusumoto's work spans molecular biology, oncology, cancer research, and psychiatry and mental health, indicating a multidisciplinary approach to complex biological questions.

Best Publications

  • Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2 IMPLICATIONS FOR CROHN′S DISEASE

    Naohiro Inohara;Yasunori Ogura;Ana Fontalba;Olga Gutierrez

  • An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid.

    Mathias Chamaillard;Masahito Hashimoto;Yasuo Horie;Junya Masumoto

  • Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide

    Egil Lien;Terry K. Means;Holger Heine;Atsutoshi Yoshimura

  • Synthetic and natural Escherichia coli free lipid A express identical endotoxic activities

    Chris Galanos;Otto Lüderitz;Ernst Th. Rietschel;Otto Westphal

  • Bacterial endotoxin: Chemical constitution, biological recognition, host response, and immunological detoxification.

    E. T. Rietschel;H. Brade;O. Holst;L. Brade

  • Monomeric and Polymeric Gram-Negative Peptidoglycan but Not Purified LPS Stimulate the Drosophila IMD Pathway

    Takashi Kaneko;Takashi Kaneko;William E. Goldman;Peter Mellroth;Hakan Steiner

  • Lipopolysaccharide Interaction with Cell Surface Toll-like Receptor 4-MD-2 Higher Affinity than That with MD-2 or CD14

    Sachiko Akashi;Shin-ichiroh Saitoh;Yasutaka Wakabayashi;Takane Kikuchi

  • Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response

    Sara W. Montminy;Naseema N. Khan;Sara C. McGrath;Mitchell J. Walkowicz

  • IL-1 induction-capacity of defined lipopolysaccharide partial structures.

    H Loppnow;H Brade;I Dürrbaum;C A Dinarello

  • The chemical structure of bacterial endotoxin in relation to bioactivity.

    Ernst Th. Rietschel;Teruo Kirikae;F. Ulrich Schade;Artur J. Ulmer

  • Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition.

    Sachiko Akashi;Yoshinori Nagai;Hirotaka Ogata;Masato Oikawa

  • TLR4-mediated inflammatory activation of human coronary artery endothelial cells by LPS

    Stefanie Zeuke;Artur J Ulmer;Shoichi Kusumoto;Hugo A Katus

  • Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization.

    Shin-ichiroh Saitoh;Sachiko Akashi;Takenao Yamada;Natsuko Tanimura

  • Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in human monocytic cells in culture.

    A. Uehara;S. Yang;Y. Fujimoto;K. Fukase

  • Aggregates are the biologically active units of endotoxin.

    Mareike Mueller;Buko Lindner;Shoichi Kusumoto;Koichi Fukase

  • Human Peptidoglycan Recognition Protein-L Is an N-Acetylmuramoyl-L-alanine Amidase

    Zheng-Ming Wang;Xinna Li;Ross R. Cocklin;Minhui Wang

  • Intrinsic conformation of lipid A is responsible for agonistic and antagonistic activity.

    Ulrich Seydel;Masato Oikawa;Koichi Fukase;Shoichi Kusumoto

  • Total Synthesis of Escherichia coli Lipid A, the Endotoxically Active Principle of Cell-Surface Lipopolysaccharide

    Masahiro Imoto;Hiroyuki Yoshimura;Tetsuo Shimamoto;Nobuki Sakaguchi

  • Endotoxic properties of chemically synthesized lipid A part structures. Comparison of synthetic lipid A precursor and synthetic analogues with biosynthetic lipid A precursor and free lipid A.

    Chris Galanos;Volker Lehmann;Otto Lüderitz;Ernst Th. Rietschel

  • Total synthesis of escherichia coli lipid A

    Masahiro Imoto;Hiroyuki Yoshimura;Nobuki Sakaguchi;Shoichi Kusumoto

Frequent Co-Authors

Tetsuo Shiba
Tetsuo Shiba Osaka University
Koichi Fukase
Koichi Fukase Osaka University
Shozo Kotani
Shozo Kotani Osaka University
Ernst Th. Rietschel
Ernst Th. Rietschel Institute for Advanced Sustainability Studies
Helmut Brade
Helmut Brade BOKU University
Hans-Dieter Flad
Hans-Dieter Flad Research Center Borstel - Leibniz-Center for Medicine and Biosciences
Haruhiko Takada
Haruhiko Takada Tohoku University
Ulrich Zähringer
Ulrich Zähringer Research Center Borstel - Leibniz-Center for Medicine and Biosciences
Tomohiko Ogawa
Tomohiko Ogawa Asahi University
Chris Galanos
Chris Galanos Max Planck Society

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