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Helmut Brade

Helmut Brade

D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
18173
World Ranking
5644
National Ranking
47

Overview

Helmut Brade was affiliated with BOKU University in Austria and contributed to multiple fields within scientific research. Their work spanned areas such as Medicine, Biochemistry, Genetics and Molecular Biology, and Materials Science, with specific focus on the subfields of Radiology, Nuclear Medicine and Imaging, Molecular Biology, and Materials Chemistry.

The central topics of Helmut Brade's research included Monoclonal and Polyclonal Antibodies Research, Glycosylation and Glycoproteins Research, and Enzyme Structure and Function. These topics reflect an interdisciplinary approach integrating biochemical and molecular biological perspectives.

Brade's publication record featured papers published in recognized scientific venues. One identified paper was titled "Antigen binding by conformational selection in near-germline antibodies," published in the Journal of Biological Chemistry in 2022. This publication was cited 13 times, indicating engagement within the scientific community focused on antibody research and molecular recognition processes.

Throughout their career, Brade collaborated with several researchers, indicating a network of coauthors involved in closely related research fields. Frequent collaborators included:

  • R.J. Blackler
  • Sven Müller-Loennies
  • Barbara A. Pokorny
  • Max S G Legg
  • Lore Brade

Helmut Brade's academic contributions were primarily disseminated through the Journal of Biological Chemistry, which was the venue for their documented paper. This venue typically publishes research in biochemistry and molecular biology, which aligns with Brade's fields of study and research focus areas.

Best Publications

  • Bacterial endotoxin: molecular relationships of structure to activity and function.

    E T Rietschel;T Kirikae;F U Schade;U Mamat

  • Synthetic and natural Escherichia coli free lipid A express identical endotoxic activities

    Chris Galanos;Otto Lüderitz;Ernst Th. Rietschel;Otto Westphal

  • Bacterial endotoxin: Chemical constitution, biological recognition, host response, and immunological detoxification.

    E. T. Rietschel;H. Brade;O. Holst;L. Brade

  • IL-1 induction-capacity of defined lipopolysaccharide partial structures.

    H Loppnow;H Brade;I Dürrbaum;C A Dinarello

  • PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide

    Rolf Göggel;Supandi Winoto-Morbach;Gabriele Vielhaber;Yumiko Imai

  • The chemical structure of bacterial endotoxin in relation to bioactivity.

    Ernst Th. Rietschel;Teruo Kirikae;F. Ulrich Schade;Artur J. Ulmer

  • Chemical structure of the lipopolysaccharide of Haemophilus influenzae strain I-69 Rd-/b+. Description of a novel deep-rough chemotype.

    Ilkka M. Helander;Buko Lindner;Helmut Brade;Klaus Altmann

  • A broadly cross-protective monoclonal antibody binding to Escherichia coli and Salmonella lipopolysaccharides.

    F E Di Padova;H Brade;G R Barclay;I R Poxton

  • A lethal role for lipid A in Salmonella infections

    Shahid A. Khan;Paul Everest;Spiros Servos;Neale Foxwell

  • Endotoxic properties of chemically synthesized lipid A part structures. Comparison of synthetic lipid A precursor and synthetic analogues with biosynthetic lipid A precursor and free lipid A.

    Chris Galanos;Volker Lehmann;Otto Lüderitz;Ernst Th. Rietschel

  • Soluble peptidoglycan-induced monokine production can be blocked by anti-CD14 monoclonal antibodies and by lipid A partial structures.

    B Weidemann;H Brade;E T Rietschel;R Dziarski

  • Differential determination of the 3-Deoxy-D-mannooctulosonic acid residues in lipopolysaccharides of Salmonella minnesota rough mutants.

    Helmut Brade;Chris Galanos;Otto Lüderitz

  • Deletion of the heptosyltransferase genes rfaC and rfaF in Escherichia coli K-12 results in an Re-type lipopolysaccharide with a high degree of 2-aminoethanol phosphate substitution.

    Werner Brabetz;Sven Muller-Loennies;Otto Holst;Helmut Brade

  • Structural Analysis of the Lipopolysaccharide fromChlamydia trachomatis Serotype L2

    Sabine Rund;Buko Lindner;Helmut Brade;Otto Holst

  • Induction of human interleukin 1 by bacterial and synthetic lipid A.

    Harald Loppnow;Lore Brade;Helmut Brade;Ernst Theodor Rietschel

  • Germline antibody recognition of distinct carbohydrate epitopes

    H.P Nguyen;N.O Seto;N.O Seto;C.R MacKenzie;L Brade

  • Endotoxic activity and chemical structure of lipopolysaccharides from Chlamydia trachomatis serotypes E and L2 and Chlamydophila psittaci 6BC.

    Holger Heine;Sven Müller-Loennies;Lore Brade;Buko Lindner

  • The immunogenicity and antigenicity of lipid A are influenced by its physicochemical state and environment.

    L Brade;K Brandenburg;H M Kuhn;S Kusumoto

  • Studies on the chemical structure of the core-lipid A region of the lipopolysaccharide of Acinetobacter calcoaceticus NCTC 10305. Detection of a new 2-octulosonic acid interlinking the core oligosaccharide and lipid A component.

    Kazuyoshi Kawahara;Helmut Brade;Ernst Th. Rietschel;Ulrich Zähringer

  • Isolation, Purification, and Chemical Analysis of the Lipopolysaccharide Analysis of the Lipopolysaccharide and Lipid A of Acinetobacter calcoaceticus NCTC 10305

    Helmut Brade;Chris Galanos

Frequent Co-Authors

Otto Holst
Otto Holst Research Center Borstel - Leibniz-Center for Medicine and Biosciences
Ernst Th. Rietschel
Ernst Th. Rietschel Institute for Advanced Sustainability Studies
Paul Kosma
Paul Kosma BOKU University
Shoichi Kusumoto
Shoichi Kusumoto Osaka University
Hans-Dieter Flad
Hans-Dieter Flad Research Center Borstel - Leibniz-Center for Medicine and Biosciences
Buko Lindner
Buko Lindner Research Center Borstel - Leibniz-Center for Medicine and Biosciences
Ulrich Zähringer
Ulrich Zähringer Research Center Borstel - Leibniz-Center for Medicine and Biosciences
Evgeny Vinogradov
Evgeny Vinogradov National Research Council Canada
Artur J. Ulmer
Artur J. Ulmer University of Freiburg
Ben J. Appelmelk
Ben J. Appelmelk Amsterdam University Medical Centers

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