World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
14128
World Ranking
13663
National Ranking
973

Holger Heine publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Holger Heine sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 145 publications — 24th percentile

24% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Holger Heine D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Holger Heine sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 57 D-Index — 31st percentile

31% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Holger Heine is affiliated with Hannover Medical School in Germany, focusing on research at the intersection of biochemistry, genetics, molecular biology, immunology, and microbiology. Their scientific contributions span 32 publications in the broader field of Biochemistry, Genetics and Molecular Biology, with a strong emphasis on Immunology and Microbiology, evidenced by 29 publications in these areas.

Their research addresses a range of topics, including:

  • Immune Response and Inflammation
  • Invertebrate Immune Response Mechanisms
  • Neurobiology and Insect Physiology Research
  • Antimicrobial Peptides and Activities
  • Genetics, Aging, and Longevity in Model Organisms
  • Inflammasome and immune disorders
  • Pediatric health and respiratory diseases

Heine's frequent collaborators include Alla Zamyatina, Tim Vierbuchen, Judith Bossen, Thomas Roeder, and Iris Bruchhaus. This network indicates a collaborative approach within immunology and molecular biology research communities.

The scientist has published in various venues, with multiple contributions to bioRxiv (Cold Spring Harbor Laboratory), Frontiers in Immunology, Nature Communications, Cell Reports, and Pharmaceuticals.

Selected recent papers authored or co-authored by Holger Heine include:

  • "Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis," 2020, Nature Communications
  • "Lipopolysaccharide Recognition in the Crossroads of TLR4 and Caspase-4/11 Mediated Inflammatory Pathways," 2020, Frontiers in Immunology
  • "Therapeutic Targeting of TLR4 for Inflammation, Infection, and Cancer: A Perspective for Disaccharide Lipid A Mimetics," 2022, Pharmaceuticals
  • "Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways," 2021, Cell Reports
  • "The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2," 2022, Proceedings of the National Academy of Sciences

The scope of their research reflects ongoing investigations into molecular mechanisms of inflammation, immune signaling pathways, and genetic regulation, positioning their work at a juncture of basic and translational science.

Best Publications

  • Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide

    Egil Lien;Terry K. Means;Holger Heine;Atsutoshi Yoshimura

  • LPS-induced cytokine production in human monocytes and macrophages.

    Manuela Rossol;Holger Heine;Undine Meusch;Dagmar Quandt

  • Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease.

    Silke Walter;Maryse Letiembre;Yang Liu;Holger Heine

  • Bacterial endotoxin: Chemical constitution, biological recognition, host response, and immunological detoxification.

    E. T. Rietschel;H. Brade;O. Holst;L. Brade

  • TLR2 – promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity

    Ulrich Zähringer;Buko Lindner;Seiichi Inamura;Holger Heine

  • LPS receptor (CD14): a receptor for phagocytosis of Alzheimer’s amyloid peptide

    Yang Liu;Silke Walter;Massimiliano Stagi;Dmitry Cherny

  • The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation.

    Antje Blumenthal;Stefan Ehlers;Jörg Lauber;Jan Buer

  • Molecular mechanisms of endotoxin activity

    Jens Schletter;Holger Heine;Artur J. Ulmer;Ernst T. Rietschel

  • Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling.

    Katja Farhat;Sabine Riekenberg;Holger Heine;Jennifer Debarry

  • Lipopolysaccharide and ceramide docking to CD14 provokes ligand‐specific receptor clustering in rafts

    Alexandra Pfeiffer;Alfred Böttcher;Evelyn Orsó;Michael Kapinsky

  • Molecular Genetic Analysis of an Endotoxin Nonresponder Mutant Cell Line A Point Mutation in a Conserved Region of Md-2 Abolishes Endotoxin-Induced Signaling

    Andra B. Schromm;Egil Lien;Philipp Henneke;Jesse C. Chow

  • Acinetobacter lwoffii and Lactococcus lactis strains isolated from farm cowsheds possess strong allergy-protective properties

    Jennifer Debarry;Holger Garn;Anna Hanuszkiewicz;Nina Dickgreber

  • TLR1- and TLR6-independent recognition of bacterial lipopeptides.

    Ute Buwitt-Beckmann;Holger Heine;Karl-Heinz Wiesmüller;Günther Jung

  • Cutting Edge: Cells That Carry A Null Allele for Toll-Like Receptor 2 Are Capable of Responding to Endotoxin

    Holger Heine;Carsten J. Kirschning;Egil Lien;Brian G. Monks

  • TLR4-mediated inflammatory activation of human coronary artery endothelial cells by LPS

    Stefanie Zeuke;Artur J Ulmer;Shoichi Kusumoto;Hugo A Katus

  • Zinc Signals Are Essential for Lipopolysaccharide-Induced Signal Transduction in Monocytes

    Hajo Haase;Julia L. Ober-Blöbaum;Gabriela Engelhardt;Silke Hebel

  • Toll-like receptor 6-independent signaling by diacylated lipopeptides.

    Ute Buwitt-Beckmann;Holger Heine;Karl-Heinz Wiesmüller;Günther Jung

  • Toll-like receptors and their function in innate and adaptive immunity.

    Holger Heine;Egil Lien

  • Lipopolysaccharide recognition, CD14, and lipopolysaccharide receptors.

    Robin R. Ingalls;Holger Heine;Egil Lien;Atsutoshi Yoshimura

  • Lipopolysaccharide Binding Protein Binds to Triacylated and Diacylated Lipopeptides and Mediates Innate Immune Responses

    Nicolas W. J. Schröder;Holger Heine;Christian Alexander;Maria Manukyan

Frequent Co-Authors

Artur J. Ulmer
Artur J. Ulmer University of Freiburg
Otto Holst
Otto Holst Research Center Borstel - Leibniz-Center for Medicine and Biosciences
Buko Lindner
Buko Lindner Research Center Borstel - Leibniz-Center for Medicine and Biosciences
Ulrich Zähringer
Ulrich Zähringer Research Center Borstel - Leibniz-Center for Medicine and Biosciences
Torsten Goldmann
Torsten Goldmann Research Center Borstel - Leibniz-Center for Medicine and Biosciences
Albrecht Bufe
Albrecht Bufe Ruhr University Bochum
Markus Ege
Markus Ege Ludwig-Maximilians-Universität München
Karl-Heinz Wiesmüller
Karl-Heinz Wiesmüller University of Tübingen
Holger Garn
Holger Garn Philipp University of Marburg
Klaus Brandenburg
Klaus Brandenburg Leibniz Institute for Neurobiology

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