Holger Heine spends much of his time researching Receptor, Cell biology, Signal transduction, TLR2 and Biochemistry. His Cell biology study combines topics from a wide range of disciplines, such as Acquired immune system, Lipid signaling, Lipopolysaccharide, CD36 and CD14. When carried out as part of a general Lipopolysaccharide research project, his work on Lipid A is frequently linked to work in Cytosol, therefore connecting diverse disciplines of study.
His Signal transduction research integrates issues from Secretion, Calcium and Immune system. He has included themes like Lipopeptide and Toll-like receptor in his TLR2 study. His Toll-like receptor research is included under the broader classification of Immunology.
Holger Heine mainly investigates Cell biology, Lipopolysaccharide, Immunology, Microbiology and Innate immune system. His Cell biology study frequently intersects with other fields, such as Toll-like receptor. His Lipopolysaccharide study also includes
His research in Microbiology tackles topics such as Allergy which are related to areas like Acinetobacter. Part of his project on Innate immune system includes research on Receptor and Immune system. His study connects Signal transduction and Receptor.
Holger Heine mainly focuses on Cell biology, Immune system, Innate immune system, Microbiology and Immunology. His work carried out in the field of Cell biology brings together such families of science as Lipopolysaccharide, Lipid A and Genetics. His work in Lipopolysaccharide addresses issues such as Inflammation, which are connected to fields such as Sepsis.
His Innate immune system course of study focuses on Nucleic acid and Receptor and Interferon. His research in Microbiology intersects with topics in Lactobacillus casei and Antigen. His studies deal with areas such as Cell and Hypoxia as well as Immunology.
His primary scientific interests are in Immune system, Microbiology, TLR8, Innate immune system and TLR7. His research integrates issues of Pathogen-associated molecular pattern, Pattern recognition receptor, Toll-like receptor, Dendritic cell and Adoptive cell transfer in his study of Microbiology. The concepts of his Innate immune system study are interwoven with issues in Proinflammatory cytokine, Gut flora, Phagocytosis and Antimicrobial peptides.
His work deals with themes such as Inflammasome and Cell biology, which intersect with TLR7. His Psoriasis study necessitates a more in-depth grasp of Immunology. His Immunology study combines topics in areas such as Flora and Intensive care medicine.
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Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
Egil Lien;Terry K. Means;Holger Heine;Atsutoshi Yoshimura.
Journal of Clinical Investigation (2000)
Bacterial endotoxin: Chemical constitution, biological recognition, host response, and immunological detoxification.
E. T. Rietschel;H. Brade;O. Holst;L. Brade.
Current Topics in Microbiology and Immunology (1996)
LPS-induced cytokine production in human monocytes and macrophages.
Manuela Rossol;Holger Heine;Undine Meusch;Dagmar Quandt.
Critical Reviews in Immunology (2011)
Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease.
Silke Walter;Maryse Letiembre;Yang Liu;Holger Heine.
Cellular Physiology and Biochemistry (2007)
LPS receptor (CD14): a receptor for phagocytosis of Alzheimer’s amyloid peptide
Yang Liu;Silke Walter;Massimiliano Stagi;Dmitry Cherny.
The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation.
Antje Blumenthal;Stefan Ehlers;Jörg Lauber;Jan Buer.
TLR2 – promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity
Ulrich Zähringer;Buko Lindner;Seiichi Inamura;Holger Heine.
Molecular mechanisms of endotoxin activity
Jens Schletter;Holger Heine;Artur J. Ulmer;Ernst T. Rietschel.
Archives of Microbiology (1995)
Lipopolysaccharide and ceramide docking to CD14 provokes ligand‐specific receptor clustering in rafts
Alexandra Pfeiffer;Alfred Böttcher;Evelyn Orsó;Michael Kapinsky.
European Journal of Immunology (2001)
Molecular Genetic Analysis of an Endotoxin Nonresponder Mutant Cell Line A Point Mutation in a Conserved Region of Md-2 Abolishes Endotoxin-Induced Signaling
Andra B. Schromm;Egil Lien;Philipp Henneke;Jesse C. Chow.
Journal of Experimental Medicine (2001)
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