D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 46 Citations 11,266 121 World Ranking 15010 National Ranking 1068

Overview

What is he best known for?

The fields of study he is best known for:

  • Bacteria
  • Immune system
  • DNA

Holger Heine spends much of his time researching Receptor, Cell biology, Signal transduction, TLR2 and Biochemistry. His Cell biology study combines topics from a wide range of disciplines, such as Acquired immune system, Lipid signaling, Lipopolysaccharide, CD36 and CD14. When carried out as part of a general Lipopolysaccharide research project, his work on Lipid A is frequently linked to work in Cytosol, therefore connecting diverse disciplines of study.

His Signal transduction research integrates issues from Secretion, Calcium and Immune system. He has included themes like Lipopeptide and Toll-like receptor in his TLR2 study. His Toll-like receptor research is included under the broader classification of Immunology.

His most cited work include:

  • Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide (679 citations)
  • Bacterial endotoxin: Chemical constitution, biological recognition, host response, and immunological detoxification. (415 citations)
  • Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease. (355 citations)

What are the main themes of his work throughout his whole career to date?

Holger Heine mainly investigates Cell biology, Lipopolysaccharide, Immunology, Microbiology and Innate immune system. His Cell biology study frequently intersects with other fields, such as Toll-like receptor. His Lipopolysaccharide study also includes

  • Biochemistry that intertwine with fields like Lipopeptide,
  • Biological activity that intertwine with fields like Liposome.

His research in Microbiology tackles topics such as Allergy which are related to areas like Acinetobacter. Part of his project on Innate immune system includes research on Receptor and Immune system. His study connects Signal transduction and Receptor.

He most often published in these fields:

  • Cell biology (30.09%)
  • Lipopolysaccharide (27.43%)
  • Immunology (23.89%)

What were the highlights of his more recent work (between 2013-2021)?

  • Cell biology (30.09%)
  • Immune system (17.70%)
  • Innate immune system (21.24%)

In recent papers he was focusing on the following fields of study:

Holger Heine mainly focuses on Cell biology, Immune system, Innate immune system, Microbiology and Immunology. His work carried out in the field of Cell biology brings together such families of science as Lipopolysaccharide, Lipid A and Genetics. His work in Lipopolysaccharide addresses issues such as Inflammation, which are connected to fields such as Sepsis.

His Innate immune system course of study focuses on Nucleic acid and Receptor and Interferon. His research in Microbiology intersects with topics in Lactobacillus casei and Antigen. His studies deal with areas such as Cell and Hypoxia as well as Immunology.

Between 2013 and 2021, his most popular works were:

  • The Intestinal Archaea Methanosphaera stadtmanae and Methanobrevibacter smithii Activate Human Dendritic Cells (68 citations)
  • Lipoproteins/peptides are sepsis-inducing toxins from bacteria that can be neutralized by synthetic anti-endotoxin peptides (34 citations)
  • Biological effects of carbon black nanoparticles are changed by surface coating with polycyclic aromatic hydrocarbons. (31 citations)

In his most recent research, the most cited papers focused on:

  • Bacteria
  • Immune system
  • DNA

His primary scientific interests are in Immune system, Microbiology, TLR8, Innate immune system and TLR7. His research integrates issues of Pathogen-associated molecular pattern, Pattern recognition receptor, Toll-like receptor, Dendritic cell and Adoptive cell transfer in his study of Microbiology. The concepts of his Innate immune system study are interwoven with issues in Proinflammatory cytokine, Gut flora, Phagocytosis and Antimicrobial peptides.

His work deals with themes such as Inflammasome and Cell biology, which intersect with TLR7. His Psoriasis study necessitates a more in-depth grasp of Immunology. His Immunology study combines topics in areas such as Flora and Intensive care medicine.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide

Egil Lien;Terry K. Means;Holger Heine;Atsutoshi Yoshimura.
Journal of Clinical Investigation (2000)

918 Citations

Bacterial endotoxin: Chemical constitution, biological recognition, host response, and immunological detoxification.

E. T. Rietschel;H. Brade;O. Holst;L. Brade.
Current Topics in Microbiology and Immunology (1996)

620 Citations

LPS-induced cytokine production in human monocytes and macrophages.

Manuela Rossol;Holger Heine;Undine Meusch;Dagmar Quandt.
Critical Reviews in Immunology (2011)

595 Citations

Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease.

Silke Walter;Maryse Letiembre;Yang Liu;Holger Heine.
Cellular Physiology and Biochemistry (2007)

552 Citations

LPS receptor (CD14): a receptor for phagocytosis of Alzheimer’s amyloid peptide

Yang Liu;Silke Walter;Massimiliano Stagi;Dmitry Cherny.
Brain (2005)

413 Citations

The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation.

Antje Blumenthal;Stefan Ehlers;Jörg Lauber;Jan Buer.
Blood (2006)

398 Citations

TLR2 – promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity

Ulrich Zähringer;Buko Lindner;Seiichi Inamura;Holger Heine.
Immunobiology (2008)

396 Citations

Molecular mechanisms of endotoxin activity

Jens Schletter;Holger Heine;Artur J. Ulmer;Ernst T. Rietschel.
Archives of Microbiology (1995)

392 Citations

Lipopolysaccharide and ceramide docking to CD14 provokes ligand‐specific receptor clustering in rafts

Alexandra Pfeiffer;Alfred Böttcher;Evelyn Orsó;Michael Kapinsky.
European Journal of Immunology (2001)

374 Citations

Molecular Genetic Analysis of an Endotoxin Nonresponder Mutant Cell Line A Point Mutation in a Conserved Region of Md-2 Abolishes Endotoxin-Induced Signaling

Andra B. Schromm;Egil Lien;Philipp Henneke;Jesse C. Chow.
Journal of Experimental Medicine (2001)

357 Citations

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