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Karl-Heinz Wiesmüller

Karl-Heinz Wiesmüller

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
10576
World Ranking
13327
National Ranking
948

Overview

Karl-Heinz Wiesmüller is affiliated with the University of Tübingen in Germany. Their research primarily focuses on Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions in Infectious Diseases and Molecular Biology as subfields. Other areas of study include Immunology, Epidemiology, and Surgery.

The scientist's work broadly covers topics related to SARS-CoV-2 and COVID-19 research, COVID-19 clinical research studies, vaccines and immunoinformatics approaches, Mycobacterium research and diagnosis, infectious diseases and tuberculosis, tuberculosis research and epidemiology, and immunotherapy and immune responses.

Frequent collaborators in their research include Hans-Georg Rammensee, Juliane S. Walz, Michael Schindler, Annika Nelde, and Markus Löffler.

Karl-Heinz Wiesmüller has published in several scientific venues, notably including bioRxiv (Cold Spring Harbor Laboratory), Vaccines, Nature Communications, International Journal of Infectious Diseases, and International Journal of Molecular Sciences.

Selected recent publications include:

  • Designing a SARS-CoV-2 T-Cell-Inducing Vaccine for High-Risk Patient Groups, 2021, Vaccines
  • Phase I/II trial of a peptide-based COVID-19 T-cell activator in patients with B-cell deficiency, 2023, Nature Communications
  • Anti-Infective and Anti-Inflammatory Mode of Action of Peptide 19-2.5, 2021, International Journal of Molecular Sciences
  • Long-term efficacy of the peptide-based COVID-19 T cell activator CoVac-1 in healthy adults, 2023, International Journal of Infectious Diseases
  • A comparison of acyl-moieties for noncovalent functionalization of PLGA and PEG-PLGA nanoparticles with a cell-penetrating peptide, 2021, RSC Advances

Best Publications

  • In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine

    Karl Deres;Hansjörg Schild;Karl-Heinz Wiesmüller;Günther Jung

  • Identification of High Potency Microbial and Self Ligands for a Human Autoreactive Class II–restricted T Cell Clone

    Bernhard Hemmer;Burkhard T. Fleckenstein;Marco Vergelli;Günther Jung

  • Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling.

    Katja Farhat;Sabine Riekenberg;Holger Heine;Jennifer Debarry

  • TLR1- and TLR6-independent recognition of bacterial lipopeptides.

    Ute Buwitt-Beckmann;Holger Heine;Karl-Heinz Wiesmüller;Günther Jung

  • Toll-like receptor 6-independent signaling by diacylated lipopeptides.

    Ute Buwitt-Beckmann;Holger Heine;Karl-Heinz Wiesmüller;Günther Jung

  • Recognition principle of the TAP transporter disclosed by combinatorial peptide libraries

    Stephan Uebel;Wolfgang Kraas;Stefan Kienle;Karl-Heinz Wiesmüller

  • Early neutralizing IgG response to Chikungunya virus in infected patients targets a dominant linear epitope on the E2 glycoprotein

    Yiu‐Wing Kam;Fok‐Moon Lum;Fok‐Moon Lum;Teck‐Hui Teo;Wendy W. L. Lee

  • Synthetic lipopeptide adjuvants and Toll-like receptor 2—structure–activity relationships

    Renate Spohn;Ute Buwitt-Beckmann;Roland Brock;Günther Jung

  • Efficiency of peptides and lipopeptides for in vivo priming of virus-specific cytotoxic T cells.

    Hansjörg Schild;Karl Deres;Karl-Heinz Wiesmüller;Günther Jung

  • Synthesis of the mitogenic S-[2,3-bis(palmitoyloxy)propyl]-N-palmitoylpentapeptide from Escherichia coli lipoprotein.

    Karl-Heinz Wiesmüller;Wolfgang Bessler;Günther Jung

  • Binding of lipopeptide to CD14 induces physical proximity of CD14, TLR2 and TLR1.

    Maria Manukyan;Kathy Triantafilou;Martha Triantafilou;Alan Mackie

  • Novel low-molecular-weight synthetic vaccine against foot-and-mouth disease containing a potent B-cell and macrophage activator.

    Karl-Heinz Wiesmüller;Günther Jung;Günter Hess

  • Electrospray Mass Spectrometry and Tandem Mass Spectrometry of Synthetic Multicomponent Peptide Mixtures: Determination of Composition and Purity

    J.W. Metzger;C. Kempter;K.H. Wiesmuller;G. Jung

  • Lipopeptide structure determines TLR2 dependent cell activation level

    Ute Buwitt-Beckmann;Holger Heine;Karl-Heinz Wiesmüller;Günther Jung

  • Synthesis of novel immunologically active tripalmitoyl-S-glycerylcysteinyl lipopeptides as useful intermediates for immunogen preparations.

    Jörg Metzger;Karl-Heinz Wiesmüller;Renate Schaude;Wolfgang G. Bessler

  • Lipopeptide derivatives of bacterial lipoprotein constitute potent immune adjuvants combined with or covalently coupled to antigen or hapten.

    Annette Reitermann;Jörg Metzger;Karl-Heinz Wiesmüller;Günther Jung

  • Vaccine-Induced, Pseudorabies Virus-Specific, Extrathymic CD4+CD8+ Memory T-Helper Cells in Swine

    Bertram T. Ober;Artur Summerfield;Christina Mattlinger;Karl-Heinz Wiesmüller

  • A fluorescence-based synthetic LPS sensor.

    Söhnke Voss;Rainer Fischer;Günther Jung;Karl-Heinz Wiesmüller

  • New Ligands Binding to the Human Leukocyte Antigen Class II Molecule DRB1*0101 Based on the Activity Pattern of an Undecapeptide Library

    Burkhard Fleckenstein;Hubert Kalbacher;Claude P. Muller;Dieter Stoll

  • Activation of bone marrow-derived mouse macrophages by bacterial lipopeptide: cytokine production, phagocytosis and Ia expression.

    S Hauschildt;P Hoffmann;H U Beuscher;G Dufhues

Frequent Co-Authors

Günther Jung
Günther Jung University of Tübingen
Peter Walden
Peter Walden Charité - University Medicine Berlin
Artur J. Ulmer
Artur J. Ulmer University of Freiburg
Armin Saalmüller
Armin Saalmüller University of Veterinary Medicine Vienna
Holger Heine
Holger Heine Hannover Medical School
Robert Weissert
Robert Weissert University of Regensburg
Olaf Rötzschke
Olaf Rötzschke Agency for Science, Technology and Research
Stefan Stevanovic
Stefan Stevanovic University of Tübingen
Albrecht Bufe
Albrecht Bufe Ruhr University Bochum
Robert Tampé
Robert Tampé Goethe University Frankfurt

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