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Immunology

D-Index
71
Citations
29625
World Ranking
2269
National Ranking
1099

Overview

Egil Lien is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research spans several areas within biochemistry, genetics, molecular biology, immunology, microbiology, and medicine, with a focus on molecular biology and immunology as primary subfields.

Their recent research outputs emphasize mechanisms of immune response, inflammation, and cell death. These include investigations into inflammasome activation, caspase-8 roles, and kinase activities relevant to disease progression and immune regulation.

  • Multiple roles of caspase-8 in cell death, inflammation, and innate immunity (2020), Journal of Leukocyte Biology
  • RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis (2021), Cell Reports
  • RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages (2020), Cell Death and Differentiation
  • Inhibition of HSP90 and Activation of HSF1 Diminish Macrophage NLRP3 Inflammasome Activity in Alcohol-Associated Liver Injury (2020), Alcoholism Clinical and Experimental Research
  • MLKL-Driven Inflammasome Activation and Caspase-8 Mediate Inflammatory Cell Death in Influenza A Virus Infection (2023), mBio

Their work is frequently published in journals such as Nature Communications, bioRxiv (Cold Spring Harbor Laboratory), Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, Journal of Leukocyte Biology, and Cell Reports.

Frequent collaborators include:

  • Pontus Ørning
  • Katherine A. Fitzgerald
  • Boyao Zhang
  • Liv Ryan
  • Terje Espevik

Main research topics covered in their studies comprise:

  • Inflammasome and immune disorders
  • Interferon and immune responses
  • Immune response and inflammation
  • Cell death mechanisms and regulation
  • Liver disease diagnosis and treatment
  • Pancreatitis pathology and treatment
  • Endoplasmic reticulum stress and disease

Best Publications

  • NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

    Peter Duewell;Hajime Kono;Katey J. Rayner;Katey J. Rayner;Cherilyn M. Sirois

  • TLR9 signals after translocating from the ER to CpG DNA in the lysosome

    Eicke Latz;Annett Schoenemeyer;Alberto Visintin;Katherine A. Fitzgerald

  • Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2

    Atsutoshi Yoshimura;Egil Lien;Robin R. Ingalls;Elaine Tuomanen

  • TOLL-LIKE RECEPTOR 2 FUNCTIONS AS A PATTERN RECOGNITION RECEPTOR FOR DIVERSE BACTERIAL PRODUCTS

    Egil Lien;Egil Lien;Timothy J. Sellati;Atsutoshi Yoshimura;Trude H. Flo

  • Human Toll-Like Receptors Mediate Cellular Activation by Mycobacterium tuberculosis

    Terry K. Means;Shuyan Wang;Egil Lien;Atsutoshi Yoshimura

  • Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.

    Pontus Orning;Pontus Orning;Dan Weng;Dan Weng;Kristian Starheim;Kristian Starheim;Dmitry Ratner

  • Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide

    Egil Lien;Terry K. Means;Holger Heine;Atsutoshi Yoshimura

  • Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy.

    Pål Aukrust;Thor Ueland;Egil Lien;Klaus Bendtzen

  • Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction.

    Eicke Latz;Alberto Visintin;Egil Lien;Egil Lien;Katherine A. Fitzgerald

  • Hemagglutinin protein of wild-type measles virus activates toll-like receptor 2 signaling

    Karen Bieback;Egil Lien;Ingo M. Klagge;Elita Avota

  • The CD14 Ligands Lipoarabinomannan and Lipopolysaccharide Differ in Their Requirement for Toll-Like Receptors

    Terry K. Means;Egil Lien;Atsutoshi Yoshimura;Shuyan Wang

  • The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia–reperfusion injury

    Øystein Sandanger;Trine Ranheim;Leif Erik Vinge;Leif Erik Vinge;Marte Bliksøen

  • Inflammatory Response After Open Heart Surgery: Release of Heat-Shock Protein 70 and Signaling Through Toll-Like Receptor-4

    Brit Dybdahl;Alexander Wahba;Egil Lien;Trude H. Flo

  • Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response

    Sara W. Montminy;Naseema N. Khan;Sara C. McGrath;Mitchell J. Walkowicz

  • Immunomodulating Therapy With Intravenous Immunoglobulin in Patients With Chronic Heart Failure

    Lars Gullestad;Halfdan Aass;Jan G. Fjeld;Lisbeth Wikeby

  • Serum levels of tumor necrosis factor-alpha (TNF alpha) and soluble TNF receptors in human immunodeficiency virus type 1 infection--correlations to clinical, immunologic, and virologic parameters.

    P Aukrust;N B Liabakk;F Müller;E Lien

  • Innate Immune Recognition of Invasive Bacteria Accelerates Atherosclerosis in Apolipoprotein E-Deficient Mice

    Frank C. Gibson;Charlie Hong;Hsin Hua Chou;Hiromichi Yumoto

  • The NLRP12 Inflammasome Recognizes Yersinia pestis

    Gregory I. Vladimer;Dan Weng;Sara W. Montminy Paquette;Sivapriya Kailasan Vanaja

  • Toll-like receptors.

    Egil Lien;Robin R. Ingalls

  • Molecular Genetic Analysis of an Endotoxin Nonresponder Mutant Cell Line A Point Mutation in a Conserved Region of Md-2 Abolishes Endotoxin-Induced Signaling

    Andra B. Schromm;Egil Lien;Philipp Henneke;Jesse C. Chow

  • Erratum: NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals (Nature (2010) 464 (1357-1361))

    Peter Duewell;Hajime Kono;Katey J. Rayner;Cherilyn M. Sirois

Frequent Co-Authors

Terje Espevik
Terje Espevik Norwegian University of Science and Technology
Douglas T. Golenbock
Douglas T. Golenbock University of Massachusetts Chan Medical School
Katherine A. Fitzgerald
Katherine A. Fitzgerald University of Massachusetts Chan Medical School
Pål Aukrust
Pål Aukrust Oslo University Hospital
Stig S. Frøland
Stig S. Frøland University of Oslo
Eicke Latz
Eicke Latz German Rheumatism Research Centre
Arne Yndestad
Arne Yndestad Oslo University Hospital
Fredrik Müller
Fredrik Müller University of Oslo
Thor Ueland
Thor Ueland University of Oslo
Ricardo T. Gazzinelli
Ricardo T. Gazzinelli Universidade Federal de Minas Gerais

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