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D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
11563
World Ranking
10418
National Ranking
4522

Overview

Philip Coffino is affiliated with Rockefeller University in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a significant focus on Medicine. The scientist's work extensively covers molecular biology and cell biology, including specialized subfields such as cancer research, radiology, nuclear medicine and imaging, and epidemiology.

The main research topics explored by Philip Coffino include:

  • Ubiquitin and proteasome pathways
  • Protein degradation and inhibitors
  • Endoplasmic reticulum stress and disease
  • Cancer, hypoxia, and metabolism
  • Autophagy in disease and therapy
  • Multiple myeloma research and treatments
  • Mitochondrial function and pathology

Philip Coffino has contributed to several notable scientific papers, including:

  • Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening, 2021, Cancer Discovery
  • Allosteric coupling between α-rings of the 20S proteasome, 2020, Nature Communications
  • Targeting BCL-XL in fibrolamellar hepatocellular carcinoma, 2022, JCI Insight
  • Disruption of proteome by an oncogenic fusion kinase alters metabolism in fibrolamellar hepatocellular carcinoma, 2023, Science Advances
  • Single molecule microscopy reveals diverse actions of substrate sequences that impair ClpX AAA+ ATPase function, 2022, Journal of Biological Chemistry

The scientist frequently publishes in venues such as Cancer Research, Nature Communications, Cancer Discovery, JCI Insight, and Science Advances. Cancer Research is the most prominent among these, with multiple publications in this journal.

Philip Coffino regularly collaborates with several colleagues, including Sanford M. Simon, Barbara A. Lyons, Mahsa Shirani, Denise Ng, and Bassem Shebl.

Best Publications

  • Regulation of cellular polyamines by antizyme.

    Philip Coffino

  • Selection of a variant lymphoma cell deficient in adenylate cyclase

    Henry R. Bourne;P. Coffino;G. M. Tomkins

  • Cloning of mouse myeloma cells and detection of rare variants.

    Philip Coffino;Reuben Baumal;Reuven Laskov;Matthew D. Scharff

  • Prevention of rapid intracellular degradation of ODC by a carboxyl-terminal truncation.

    L Ghoda;T van Daalen Wetters;M Macrae;D Ascherman

  • Mutations causing charge alterations in regulatory subunits of the cAMP-dependent protein kinase of cultured S49 lymphoma cells

    Robert A. Steinberg;Patrick H. O'Farrell;Ursula Friedrich;Philip Coffino

  • Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate

    Mingsheng Zhang;Cecile M. Pickart;Philip Coffino

  • Agonist-specific refractoriness induced by isoproterenol. Studies with mutant cells.

    M Shear;P A Insel;K L Melmon;P Coffino

  • Ubiquitin-independent proteasomal degradation

    Jenny Erales;Philip Coffino

  • High-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradation.

    X Li;P Coffino

  • Molecular cloning and expression of the mouse ornithine decarboxylase gene

    Lisa McConlogue;Madhu Gupta;Lily Wu;Philip Coffino

  • Rate of Somatic Mutation in Immunoglobulin Production by Mouse Myeloma Cells

    Philip Coffino;Matthew D. Scharff

  • Ubistatins Inhibit Proteasome-Dependent Degradation by Binding the Ubiquitin Chain

    Rati Verma;Noel R. Peters;Mariapina D'Onofrio;Gregory P. Tochtrop

  • Cloning and sequencing of the ornithine decarboxylase gene from Trypanosoma brucei. Implications for enzyme turnover and selective difluoromethylornithine inhibition.

    M A Phillips;M A Phillips;P Coffino;C C Wang

  • Sequestered end products and enzyme regulation: the case of ornithine decarboxylase.

    Rowland H. Davis;David R. Morris;Philip Coffino

  • Degradation of ornithine decarboxylase: exposure of the C-terminal target by a polyamine-inducible inhibitory protein.

    Xianqiang Li;P. Coffino

  • The cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome system.

    Sae-Hun Park;Natalia Bolender;Frederik Eisele;Zlatka Kostova

  • Cyclic AMP-dependent protein kinase: pivotal role in regulation of enzyme induction and growth.

    Paul A. Insel;Henry R. Bourne;Philip Coffino;Gordon M. Tomkins

  • Regulated degradation of ornithine decarboxylase requires interaction with the polyamine-inducible protein antizyme

    X Li;P Coffino

  • Structure of mammalian ornithine decarboxylase at 1.6 Å resolution: stereochemical implications of PLP-dependent amino acid decarboxylases

    Andrew D Kern;Marcos A Oliveira;Philip Coffino;Marvin L Hackert

  • Eighth International Workshop on Human Gene Mapping

    A.C. Chandley;P. Goetz;T.B. Hargreave;A.M. Joseph

Frequent Co-Authors

Henry R. Bourne
Henry R. Bourne University of California, San Francisco
Paul A. Insel
Paul A. Insel University of California, San Diego
Gordon M. Tomkins
Gordon M. Tomkins University of California, San Francisco
Ching C. Wang
Ching C. Wang University of California, San Francisco
Dieter H. Wolf
Dieter H. Wolf University of Stuttgart
Kathleen M. Sakamoto
Kathleen M. Sakamoto Stanford University
Olli A. Jänne
Olli A. Jänne University of Helsinki
Peter D'Eustachio
Peter D'Eustachio New York University
Kay Hofmann
Kay Hofmann University of Cologne
Joe W. Gray
Joe W. Gray Oregon Health & Science University

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