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Nicole L. La Gruta

Nicole L. La Gruta

D-Index & Metrics

Microbiology

D-Index
52
Citations
8473
World Ranking
4243
National Ranking
131

Overview

Nicole L. La Gruta is affiliated with Monash University in Australia and has a research focus spanning immunology, microbiology, and medicine. Their work encompasses a wide range of topics primarily related to immune system function, with significant attention to T-cell and B-cell immunology, immune cell interactions, and immunotherapy responses.

The scientist has contributed extensively to the following main topics of research:

  • T-cell and B-cell Immunology
  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • CAR-T cell therapy research
  • Vaccines and immunoinformatics approaches
  • Influenza Virus Research Studies
  • Immune Response and Inflammation

In terms of fields of study, Nicole L. La Gruta's work is situated mainly within:

  • Immunology and Microbiology
  • Medicine

Subfields of particular focus include:

  • Immunology
  • Oncology
  • Epidemiology
  • Molecular Biology
  • Public Health, Environmental and Occupational Health

The scientist has an extensive publication record, with papers frequently appearing in notable venues. Most frequent publication venues include:

  • The Journal of Immunology
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Immunology
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature

Recent research papers authored or co-authored by Nicole L. La Gruta include:

  • Evaluation of inflammation and follicle depletion during ovarian ageing in mice, 2021, Scientific Reports
  • Canonical T cell receptor docking on peptide-MHC is essential for T cell signaling, 2021, Science
  • Checkpoint inhibitor immunotherapy diminishes oocyte number and quality in mice, 2022, Nature Cancer
  • A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver TRM Cell-Mediated Immunity against Malaria in Mice, 2020, Cell Host & Microbe
  • Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients, 2021, Nature Communications

Nicole L. La Gruta frequently collaborates with other researchers, with common co-authors including:

  • Pirooz Zareie
  • Claerwen M. Jones
  • Angela Nguyen
  • Jamie Rossjohn
  • Stephen T. Turner

Best Publications

  • Quantifiable predictive features define epitope-specific T cell receptor repertoires

    Pradyot K Dash;Andrew J. Fiore-Gartland;Tomer Hertz;Tomer Hertz;George C. Wang

  • A question of self-preservation: immunopathology in influenza virus infection.

    Nicole L La Gruta;Katherine Kedzierska;John Stambas;Peter C Doherty;Peter C Doherty

  • A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

    Stephen Scally;Jan Petersen;Soi Cheng Cheng Law;Nadine Lee Dudek

  • Understanding the drivers of MHC restriction of T cell receptors

    Nicole L. La Gruta;Stephanie Gras;Stephen R. Daley;Paul G. Thomas

  • Hierarchies in Cytokine Expression Profiles for Acute and Resolving Influenza Virus-Specific CD8 + T Cell Responses: Correlation of Cytokine Profile and TCR Avidity

    Nicole L. La Gruta;Stephen J. Turner;Peter C. Doherty;Peter C. Doherty

  • Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells

    Kylie M. Quinn;Annette Fox;Kim L. Harland;Brendan E. Russ

  • Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.

    Joshua D Ooi;Jan Petersen;Jan Petersen;Yu H Tan;Megan Huynh

  • Evaluation of inflammation and follicle depletion during ovarian ageing in mice.

    Carolina Lliberos;Seng H. Liew;Pirooz Zareie;Nicole L. La Gruta

  • T-cell receptor recognition of HLA-DQ2–gliadin complexes associated with celiac disease

    Jan Petersen;Veronica Montserrat;Jorge R Mujico;Khai Lee Loh

  • A virus-specific CD8 + T cell immunodominance hierarchy determined by antigen dose and precursor frequencies

    Nicole L. La Gruta;Katherine Kedzierska;Ken C Pang;Richard Webby

  • Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion

    Nicole L. La Gruta;William T. Rothwell;Tania Cukalac;Natasha G. Swan

  • T cell mediated immunity to influenza: mechanisms of viral control

    Nicole L. La Gruta;Stephen J. Turner

  • Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations.

    Stephen John Turner;Katherine Kedzierska;Helen Komodromou;Nicole Louise La Gruta

  • Sizing up the key determinants of the CD8 + T cell response

    David C Tscharke;Nathan P Croft;Peter C Doherty;Peter C Doherty;Nicole L La Gruta

  • The Majority of Immunogenic Epitopes Generate CD4+ T Cells That Are Dependent on MHC Class II-Bound Peptide-Flanking Residues

    Paula Y. Arnold;Nicole L. La Gruta;Tim Miller;Kate M. Vignali

  • Most viral peptides displayed by class I MHC on infected cells are immunogenic.

    Nathan P Croft;A. J. Stewart Smith;Jana Pickering;John Sidney

  • Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease.

    Zhongfang Wang;Zhongfang Wang;Lingyan Zhu;Thi H. O. Nguyen;Yanmin Wan

  • A trans-Golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivo

    Zi Zhao Lieu;John G. Lock;Luke A. Hammond;Nicole L. La Gruta

  • Reversed T Cell Receptor Docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune Response.

    Stephanie Gras;Jesseka Chadderton;Jesseka Chadderton;Claudia M. Del Campo;Carine Farenc

  • Canonical T cell receptor docking on peptide–MHC is essential for T cell signaling

    Pirooz Zareie;Christopher Szeto;Carine Farenc;Sachith D. Gunasinghe

  • Peripheral T cell expansion in lymphopenic mice results in a restricted T cell repertoire.

    Nicole L. La Gruta;Ian R. van Driel;Paul A. Gleeson

  • Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity

    Katherine Kedzierska;Nicole L La Gruta;John Stambas;Stephen J Turner

Frequent Co-Authors

Peter C. Doherty
Peter C. Doherty University of Melbourne
Stephen J. Turner
Stephen J. Turner Monash University
Jamie Rossjohn
Jamie Rossjohn Monash University
Katherine Kedzierska
Katherine Kedzierska University of Melbourne
Paul G. Thomas
Paul G. Thomas St. Jude Children's Research Hospital
Anthony W. Purcell
Anthony W. Purcell Monash University
Stephanie Gras
Stephanie Gras La Trobe University
Lorena E. Brown
Lorena E. Brown University of Melbourne
David C. Tscharke
David C. Tscharke Australian National University
Tony Tiganis
Tony Tiganis Peter MacCallum Cancer Centre

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