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Biology and Biochemistry

D-Index
64
Citations
14348
World Ranking
9687
National Ranking
4271

Overview

H. Leighton Grimes is affiliated with Cincinnati Children's Hospital Medical Center in the United States and has contributed extensively to research in medicine, biochemistry, genetics, molecular biology, immunology, and microbiology. Their scholarly activity spans a broad range of topics related to hematology, immunology, and molecular biology with particular attention to acute myeloid leukemia research, single-cell and spatial transcriptomics, and immune cells in cancer.

Their notable recent publications include:

  • Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor, 2020, Immunity
  • Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition, 2020, Cell Stem Cell
  • In situ mapping identifies distinct vascular niches for myelopoiesis, 2021, Nature
  • Mouse models of neutropenia reveal progenitor-stage-specific defects, 2020, Nature
  • An immunophenotype-coupled transcriptomic atlas of human hematopoietic progenitors, 2024, Nature Immunology

The scientist's frequent co-authors include:

  • Nathan Salomonis (39 publications)
  • Baobao Song (16 publications)
  • Kyle Ferchen (12 publications)
  • André Olsson (9 publications)
  • Chih-Hsing Chou (9 publications)

H. Leighton Grimes often publishes in venues such as:

  • Blood (15 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (6 publications)
  • Nature Immunology (5 publications)
  • Experimental Hematology (4 publications)
  • Nature (3 publications)

The main fields of study include:

  • Medicine (64 publications)
  • Biochemistry, Genetics and Molecular Biology (55 publications)
  • Immunology and Microbiology (41 publications)

Subfields of study cover:

  • Molecular Biology (43 publications)
  • Immunology (40 publications)
  • Hematology (33 publications)
  • Genetics (11 publications)
  • Physiology (6 publications)

Main research topics are:

  • Acute Myeloid Leukemia Research (40 publications)
  • Single-cell and spatial transcriptomics (32 publications)
  • Immune cells in cancer (28 publications)
  • Hematopoietic Stem Cell Transplantation (20 publications)
  • Erythrocyte Function and Pathophysiology (12 publications)
  • Epigenetics and DNA Methylation (12 publications)
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms (10 publications)

Best Publications

  • Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway *

    Robin C. Muise-Helmericks;H. Leighton Grimes;Alfonso Bellacosa;Scott E. Malstrom

  • Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

    Paul A. Northcott;Catherine Lee;Catherine Lee;Thomas Zichner;Adrian M. Stütz

  • Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival.

    Jung-Hyun Park;Qing Yu;Batu Erman;Jacob S. Appelbaum

  • Single-cell analysis of mixed-lineage states leading to a binary cell fate choice

    Andre Olsson;Meenakshi Venkatasubramanian;Viren K. Chaudhri;Bruce J. Aronow

  • Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2.

    Richard E. Person;Feng Qian Li;Zhijun Duan;Kathleen F. Benson

  • Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes

    Alberto Yáñez;Simon Coetzee;Andre Olsson;David Muench

  • Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells

    Brent W Sutherland;Jill Kucab;Joyce Wu;Cathy Lee

  • The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival.

    Deeann Wallis;Melanie Hamblen;Yi Zhou;Koen J. T. Venken

  • Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis.

    Sara Wojciechowski;Pulak Tripathi;Tristan Bourdeau;Luis Acero

  • Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization.

    Relja Popovic;Laurie E. Riesbeck;Chinavenmeni S. Velu;Aditya Chaubey

  • Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor

    Immanuel Kwok;Immanuel Kwok;Etienne Becht;Yu Xia;Yu Xia;Melissa Ng

  • Gfi1 regulates miR-21 and miR-196b to control myelopoiesis

    Chinavenmeni S. Velu;Avinash M. Baktula;H. Leighton Grimes

  • Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells

    Susumu Goyama;Janet Schibler;Lea Cunningham;Yue Zhang

  • P63 expression in lung carcinoma: a tissue microarray study of 408 cases.

    N. H. C. Au;A. M. Gown;M. Cheang;D. Huntsman

  • Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1.

    Zhijun Duan;Adrian Zarebski;Diego Montoya-Durango;H. Leighton Grimes

  • The Human Cell Atlas bone marrow single-cell interactive web portal

    Stuart B. Hay;Kyle Ferchen;Kashish Chetal;H. Leighton Grimes;H. Leighton Grimes

  • DoubletDecon: Deconvoluting Doublets from Single-Cell RNA-Sequencing Data

    Erica A.K. DePasquale;Erica A.K. DePasquale;Daniel J. Schnell;Pieter-Jan Van Camp;Pieter-Jan Van Camp;Íñigo Valiente-Alandí

  • The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation

    Betty Tong;H. Leighton Grimes;Tong-Yuan Yang;Susan E. Bear

  • Evaluation of immunohistochemical markers in non-small cell lung cancer by unsupervised hierarchical clustering analysis: a tissue microarray study of 284 cases and 18 markers.

    N H C Au;M Cheang;D G Huntsman;E Yorida

  • Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia.

    Emmalee R. Adelman;Emmalee R. Adelman;Hsuan Ting Huang;Alejandro Roisman;André Olsson

Frequent Co-Authors

Nathan Salomonis
Nathan Salomonis Cincinnati Children's Hospital Medical Center
Bruce J. Aronow
Bruce J. Aronow Cincinnati Children's Hospital Medical Center
Jose A. Cancelas
Jose A. Cancelas Cincinnati Children's Hospital Medical Center
David A. Hildeman
David A. Hildeman Cincinnati Children's Hospital Medical Center
Tarik Möröy
Tarik Möröy University of Montreal
Anil G. Jegga
Anil G. Jegga Cincinnati Children's Hospital Medical Center
Harinder Singh
Harinder Singh University of Pittsburgh
Marshall S. Horwitz
Marshall S. Horwitz University of Washington
James C. Mulloy
James C. Mulloy Cincinnati Children's Hospital Medical Center
Angelo D'Alessandro
Angelo D'Alessandro University of Colorado Denver

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