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Biology and Biochemistry

D-Index
60
Citations
17074
World Ranking
11762
National Ranking
5058

Overview

James C. Mulloy is affiliated with Cincinnati Children's Hospital Medical Center in the United States. Their research primarily focuses on areas within biochemistry, genetics, and molecular biology, as well as medicine. The main subfields associated with their work include molecular biology, hematology, immunology, public health, environmental and occupational health, and oncology.

The scientist's work encompasses several key topics such as acute myeloid leukemia research, RNA modifications and cancer, epigenetics and DNA methylation, cancer-related gene regulation, acute lymphoblastic leukemia research, immune cell function and interaction, and protein degradation and inhibitors.

Recent notable publications by James C. Mulloy include:

  • Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion, 2020, Cancer Cell
  • The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia, 2022, Cancer Cell
  • Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition, 2020, Cell stem cell
  • METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism, 2023, Cell stem cell
  • In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice, 2023, Nature Biotechnology

Regular collaborators with James C. Mulloy include:

  • Mark Wunderlich, with 21 co-authored publications
  • Jianjun Chen, with 9 co-authored publications
  • Xiaolan Deng, with 7 co-authored publications
  • Zhenhua Chen, with 7 co-authored publications
  • Guido Marcucci, with 7 co-authored publications

The scientist frequently publishes in venues such as:

  • Blood (4 publications)
  • Cell stem cell (3 publications)
  • Cancer Cell (2 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (2 publications)
  • Nature Biotechnology (1 publication)

Best Publications

  • RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

    Johannes Zuber;Junwei Shi;Junwei Shi;Eric Wang;Amy R. Rappaport;Amy R. Rappaport

  • R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling

    Rui Su;Lei Dong;Chenying Li;Sigrid Nachtergaele

  • METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification

    Hengyou Weng;Huilin Huang;Huizhe Wu;Xi Qin

  • Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.

    Yue Huang;Rui Su;Yue Sheng;Lei Dong;Lei Dong

  • Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.

    Thi-Sau Migone;Jian-Xin Lin;Anna Cereseto;James C. Mulloy

  • Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

    Rui Su;Lei Dong;Yangchan Li;Min Gao

  • AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3

    Wunderlich M;Chou Fs;Link Ka;Mizukawa B

  • Rac1 GTPase: A “Rac” of All Trades

    E. E. Bosco;J. C. Mulloy;Y. Zheng

  • Microenvironment Determines Lineage Fate in a Human Model of MLL-AF9 Leukemia

    Junping Wei;Mark Wunderlich;Catherine Fox;Sara Alvarez

  • Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins.

    Shigeki Takemoto;James C. Mulloy;Anna Cereseto;Thi-Sao Migone

  • The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells.

    James C. Mulloy;Jörg Cammenga;Karen L. MacKenzie;Francisco J. Berguido

  • PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells

    Paolo Neviani;Jason G. Harb;Joshua J. Oaks;Ramasamy Santhanam

  • TET1 plays an essential oncogenic role in MLL-rearranged leukemia

    Hao Huang;Xi Jiang;Zejuan Li;Yuanyuan Li

  • Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells

    Susumu Goyama;Janet Schibler;Lea Cunningham;Yue Zhang

  • Human T-Cell Lymphotropic/Leukemia Virus Type 1 Tax Abrogates p53-Induced Cell Cycle Arrest and Apoptosis through Its CREB/ATF Functional Domain

    J. C. Mulloy;T. Kislyakova;A. Cereseto;L. Casareto

  • Targeting IRAK1 as a Therapeutic Approach for Myelodysplastic Syndrome

    Garrett W. Rhyasen;Lyndsey Bolanos;Lyndsey Bolanos;Jing Fang;Andres Jerez

  • miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia

    Zejuan Li;Hao Huang;Ping Chen;Miao He;Miao He

  • Rho GTPases in hematopoiesis and hemopathies

    James C. Mulloy;Jose A. Cancelas;Marie-Dominique Filippi;Theodosia A. Kalfa

  • Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia.

    Shuangli Mi;Zejuan Li;Ping Chen;Chunjiang He

  • The human T-cell leukemia/lymphotropic virus type I p12I protein cooperates with the E5 oncoprotein of bovine papillomavirus in cell transformation and binds the 16-kilodalton subunit of the vacuolar H+ ATPase.

    G Franchini;J C Mulloy;I J Koralnik;A Lo Monico

Frequent Co-Authors

Yi Zheng
Yi Zheng Cincinnati Children's Hospital Medical Center
Genoveffa Franchini
Genoveffa Franchini National Institutes of Health
Jaroslaw P. Maciejewski
Jaroslaw P. Maciejewski Cleveland Clinic
H. Leighton Grimes
H. Leighton Grimes Cincinnati Children's Hospital Medical Center
Jose A. Cancelas
Jose A. Cancelas Cincinnati Children's Hospital Medical Center
Guido Marcucci
Guido Marcucci City Of Hope National Medical Center
Daniel G. Tenen
Daniel G. Tenen National University of Singapore
Juan C. Cigudosa
Juan C. Cigudosa Instituto de Salud Carlos III
Chuan He
Chuan He University of Chicago
Warren J. Leonard
Warren J. Leonard National Institutes of Health

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