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Molecular Biology

D-Index
69
Citations
19558
World Ranking
1465
National Ranking
113

Overview

Andrew D. Sharrocks is affiliated with the University of Manchester in the United Kingdom. Their research spans several fields, primarily within biochemistry, genetics, and molecular biology, with a significant focus on medicine. The scientist's work further concentrates on specific subfields such as molecular biology, genetics, pulmonary and respiratory medicine, cancer research, and oncology.

The research topics covered by Andrew D. Sharrocks include:

  • Cancer-related gene regulation
  • RNA modifications and cancer
  • Genomics and chromatin dynamics
  • Epigenetics and DNA methylation
  • Single-cell and spatial transcriptomics
  • Cancer genomics and diagnostics
  • Lung cancer treatments and mutations

Prominent publication venues where Andrew D. Sharrocks has contributed include:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • eLife
  • Oncogene

Frequent co-authors in Andrew D. Sharrocks' research include:

  • Ginny Devonshire
  • Yeng Ang
  • Francesca D. Ciccarelli
  • Rebecca C. Fitzgerald
  • Ahmad Miremadi

Recent notable publications demonstrate a focus on cancer biology and genomics, including:

  • "Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders," 2020, Nature Communications
  • "Cooperative behaviour and phenotype plasticity evolve during melanoma progression," 2020, Pigment Cell & Melanoma Research
  • "Mutational signature dynamics shaping the evolution of oesophageal adenocarcinoma," 2023, Nature Communications
  • "eRNA profiling uncovers the enhancer landscape of oesophageal adenocarcinoma and reveals new deregulated pathways," 2023, eLife
  • "Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas," 2022, Communications Biology

Best Publications

  • The ETS-domain transcription factor family

    Andrew D. Sharrocks

  • Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

    Alan J. Whitmarsh;Paul Shore;Andrew D. Sharrocks;Roger J. Davis

  • The MADS‐Box Family of Transcription Factors

    Paul Shore;Andrew D. Sharrocks

  • Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence.

    Naoko Ohtani;Zoe Zebedee;Thomas J. G. Huot;Julie A. Stinson

  • Transcriptional regulation by the MAP kinase signaling cascades

    Shen Hsi Yang;Andrew D. Sharrocks;Alan J. Whitmarsh

  • Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors.

    Alan J. Whitmarsh;Shen Hsi Yang;Michael S S Su;Andrew D. Sharrocks

  • Docking domains and substrate-specificity determination for MAP kinases

    Andrew D. Sharrocks;Shen His Yang;Alex Galanis;Alex Galanis

  • MAP kinase signalling cascades and transcriptional regulation.

    Shen Hsi Yang;Andrew D. Sharrocks;Alan J. Whitmarsh

  • The ETS-domain transcription factor family

    A. D. Sharrocks;A. L. Brown;Yan Ling;P. R. Yates

  • SUMO promotes HDAC-mediated transcriptional repression.

    Shen Hsi Yang;Andrew D. Sharrocks

  • Differential targeting of MAP kinases to the ETS‐domain transcription factor Elk‐1

    Shen Hsi Yang;Alan J. Whitmarsh;Roger J. Davis;Andrew D. Sharrocks

  • The Elk-1 ETS-domain transcription factor contains a mitogen-activated protein kinase targeting motif.

    Shen Hsi Yang;Paula R. Yates;Alan J. Whitmarsh;Roger J. Davis

  • Insights into early vasculogenesis revealed by expression of the ETS-domain transcription factor Fli-1 in wild-type and mutant zebrafish embryos.

    Louise A Brown;Adam R.F Rodaway;Thomas F Schilling;Trevor Jowett

  • Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors

    Shen Hsi Yang;Alex Galanis;Andrew D. Sharrocks

  • Dynamic Interplay of the SUMO and ERK Pathways in Regulating Elk-1 Transcriptional Activity

    Shen Hsi Yang;Ellis Jaffray;Ron T. Hay;Andrew D. Sharrocks

  • An extended consensus motif enhances the specificity of substrate modification by SUMO

    Shen Hsi Yang;Alex Galanis;James Witty;Andrew D. Sharrocks

  • The Forkhead Transcription Factor FOXM1 Controls Cell Cycle-Dependent Gene Expression through an Atypical Chromatin Binding Mechanism

    Xi Chen;Gerd A. Müller;Marianne Quaas;Martin Fischer

  • MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300

    Qi Jing Li;Shen Hsi Yang;Yutaka Maeda;Frances M. Sladek

  • Temporal recruitment of the mSin3A-histone deacetylase corepressor complex to the ETS domain transcription factor Elk-1

    Shen-Hsi Yang;Elaine Vickers;Elaine Vickers;Alexander Brehm;Tony Kouzarides

  • The transcription factors Elk-1 and serum response factor interact by direct protein-protein contacts mediated by a short region of Elk-1.

    Paul Shore;Andrew D. Sharrocks

Frequent Co-Authors

Neil A. Hanley
Neil A. Hanley University of Manchester
Alan J. Whitmarsh
Alan J. Whitmarsh University of Manchester
Roger J. Davis
Roger J. Davis University of Massachusetts Chan Medical School
Ronald T. Hay
Ronald T. Hay University of Dundee
Jeremy H. Lakey
Jeremy H. Lakey Newcastle University
Rebecca C. Fitzgerald
Rebecca C. Fitzgerald University of Cambridge
Stephen G. Oliver
Stephen G. Oliver University of Cambridge
Matthew E. Hurles
Matthew E. Hurles Wellcome Sanger Institute
Simon E. Fisher
Simon E. Fisher Max Planck Society
Daniel G. MacArthur
Daniel G. MacArthur Garvan Institute of Medical Research

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