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Biology and Biochemistry

D-Index
41
Citations
7383
World Ranking
19549
National Ranking
1332

Overview

Stefan Höning is affiliated with the University of Cologne in Germany. Their research primarily focuses on Biochemistry, Genetics and Molecular Biology, with significant contributions in the subfields of Molecular Biology, Cell Biology, Genetics, Radiology, Nuclear Medicine and Imaging, and Immunology.

The scientist's work covers a range of topics in life sciences, including:

  • Cellular transport and secretion
  • Monoclonal and Polyclonal Antibodies Research
  • Genetics and Neurodevelopmental Disorders
  • Ubiquitin and proteasome pathways
  • Complement system in diseases
  • Extracellular vesicles in disease
  • Lipid Membrane Structure and Behavior

Several recent publications highlight the scope of Stefan Höning's research:

  • Inhibition of clathrin-mediated endocytosis by knockdown of AP -2 leads to alterations in the plasma membrane proteome, 2020, Traffic
  • FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P 2 -dependent switch, 2022, Science Advances
  • An update of pathogenic variants in ASPM, WDR62, CDK5RAP2, STIL, CENPJ, and CEP135 underlying autosomal recessive primary microcephaly in 32 consanguineous families from Pakistan, 2020, Molecular Genetics & Genomic Medicine
  • De novo variants of CSNK2B cause a new intellectual disability-craniodigital syndrome by disrupting the canonical Wnt signaling pathway, 2022, Human Genetics and Genomics Advances
  • Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis, 2020, Life Science Alliance

Stefan Höning frequently collaborates with several coauthors, among them:

  • Maria Asif
  • Uzma Abdullah
  • Emrah Kaygusuz
  • Birgit Budde
  • Peter Nürnberg

Their studies have appeared in multiple publication venues including:

  • Traffic
  • Science Advances
  • Molecular Genetics & Genomic Medicine
  • Human Genetics and Genomics Advances
  • Genes

Best Publications

  • A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3

    S Höning;I V Sandoval;K von Figura

  • A Large-Scale Conformational Change Couples Membrane Recruitment to Cargo Binding in the AP2 Clathrin Adaptor Complex

    Lauren P. Jackson;Bernard T. Kelly;Airlie J. McCoy;Thomas Gaffry

  • A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex

    Bernard T. Kelly;Airlie J. McCoy;Kira Späte;Sharon E. Miller

  • Phosphatidylinositol-(4,5)-bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2.

    Stefan Höning;Doris Ricotta;Michael Krauss;Kira Späte

  • Phosphorylation of the AP2 μ subunit by AAK1 mediates high affinity binding to membrane protein sorting signals

    Doris Ricotta;Sean D. Conner;Sandra L. Schmid;Kurt Von Figura

  • TIP47 functions in the biogenesis of lipid droplets

    Anna V. Bulankina;Anke Deggerich;Dirk Wenzel;Kudzai Mutenda

  • AP-4 binds basolateral signals and participates in basolateral sorting in epithelial MDCK cells

    Thomas Simmen;Thomas Simmen;Stefan Höning;Ann Icking;Ritva Tikkanen

  • AP2 controls clathrin polymerization with a membrane-activated switch

    Bernard T. Kelly;Stephen C. Graham;Nicole Liska;Philip N. Dannhauser

  • CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature.

    Sharon E. Miller;Signe Mathiasen;Nicholas A. Bright;Fabienne Pierre

  • Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylation.

    Carol Pitcher;Stefan Höning;Anja Fingerhut;Katherine Bowers

  • The Molecular Basis for the Endocytosis of Small R-SNAREs by the Clathrin Adaptor CALM

    Sharon E. Miller;Daniela A. Sahlender;Stephen C. Graham;Stefan Höning

  • The Highly Conserved C-Terminal Dileucine Motif in the Cytosolic Domain of the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Is Critical for Its Association with the AP-1 Clathrin Adapter

    Stéphanie Wyss;Clarisse Berlioz-Torrent;Michael Boge;Guillaume Blot

  • The R-SNARE Endobrevin/VAMP-8 Mediates Homotypic Fusion of Early Endosomes and Late Endosomes

    Wolfram Antonin;Claudia Holroyd;Ritva Tikkanen;Stefan Höning

  • Deficiency of UDP-galactose:N-acetylglucosamine β-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId

    Bengt Hanßke;Christian Thiel;Torben Lübke;Martin Hasilik

  • Cytoplasmic determinants involved in direct lysosomal sorting, endocytosis, and basolateral targeting of rat lgp120 (lamp-I) in MDCK cells.

    S Höning;W Hunziker

  • Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1

    Tina Gimm;Melanie Wiese;Barbara Teschemacher;Anke Deggerich

  • ArabidopsisµA-adaptin interacts with the tyrosine motif of the vacuolar sorting receptor VSR-PS1

    Nicole Happel;Stefan Honing;Jean-Marc Neuhaus;Nadine Paris

  • β-Arrestin Binding to CC Chemokine Receptor 5 Requires Multiple C-terminal Receptor Phosphorylation Sites and Involves a Conserved Asp-Arg-Tyr Sequence Motif

    Friederike Hüttenrauch;Antje Nitzki;Fang Tsyr Lin;Stefan Höning

  • The leucine-based sorting motifs in the cytoplasmic domain of the invariant chain are recognized by the clathrin adaptors AP1 and AP2 and their medium chains.

    Michael W. Hofmann;Stefan Höning;Dmitrii Rodionov;Bernhard Dobberstein

  • The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Vα14i NKT cells

    Dirk Elewaut;Anna P. Lawton;Niranjana A. Nagarajan;Niranjana A. Nagarajan;Emanual Michael Maverakis

Frequent Co-Authors

Kurt von Figura
Kurt von Figura University of Göttingen
Elena I. Rugarli
Elena I. Rugarli University of Cologne
Oddmund Bakke
Oddmund Bakke University of Oslo
Mitchell Kronenberg
Mitchell Kronenberg University of California, San Diego
Angelika A. Noegel
Angelika A. Noegel University of Cologne
Peter Nürnberg
Peter Nürnberg University of Cologne
Walter Hunziker
Walter Hunziker Agency for Science, Technology and Research
Volker Haucke
Volker Haucke Freie Universität Berlin
Eicke Latz
Eicke Latz German Rheumatism Research Centre
Matthew L. Warman
Matthew L. Warman Boston Children's Hospital

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