Her main research concerns Paraplegin, Cell biology, Mitochondrion, Hereditary spastic paraplegia and Biochemistry. Her Paraplegin study incorporates themes from Oculomotor apraxia, Exome sequencing, Spinal cord and Pathology. Her work deals with themes such as Respiratory Chain Deficiency, Mitochondrial protein synthesis and Skeletal muscle, which intersect with Cell biology.
Her study looks at the relationship between Mitochondrion and fields such as mitochondrial fusion, as well as how they intersect with chemical problems. Her Hereditary spastic paraplegia study necessitates a more in-depth grasp of Genetics. Her study in the field of Tissue specific also crosses realms of AAA proteins, Protease, Proteases and FGF21.
Her primary scientific interests are in Cell biology, Mitochondrion, Genetics, Hereditary spastic paraplegia and Spastin. Her research in the fields of Mitochondrial biogenesis overlaps with other disciplines such as Kallmann syndrome. In general Mitochondrion study, her work on Inner mitochondrial membrane often relates to the realm of Proteases, thereby connecting several areas of interest.
She is studying Paraplegin, which is a component of Hereditary spastic paraplegia. Elena I. Rugarli works mostly in the field of Spastin, limiting it down to topics relating to Microtubule and, in certain cases, Lipid droplet. Her Neurodegeneration research incorporates elements of Kinase and Spinocerebellar ataxia.
Elena I. Rugarli mainly focuses on Cell biology, Mitochondrion, Spastin, Mitochondrial biogenesis and Biochemistry. Elena I. Rugarli is interested in Respiratory chain, which is a field of Cell biology. Her Mitochondrion research incorporates themes from Translation, mitochondrial fusion, Neurodegeneration and Function.
Her mitochondrial fusion study combines topics from a wide range of disciplines, such as HEK 293 cells, ATP–ADP translocase and Mitochondrial fission. Her Spastin research includes themes of Evolutionary biology, Microtubule, Lipid droplet and Endogeny. Her work on Proteostasis, Interactome, Cell growth and Inner membrane as part of general Biochemistry research is frequently linked to Tafazzin, thereby connecting diverse disciplines of science.
The scientist’s investigation covers issues in Cell biology, Mitochondrion, Biochemistry, mitochondrial fusion and Neurodegeneration. Her Cell biology research is multidisciplinary, incorporating perspectives in Respiratory Chain Deficiency, Optic Atrophy 1 and Tissue specific. Her work carried out in the field of Mitochondrion brings together such families of science as HEK 293 cells, Cell growth and DNAJA3.
Her work on Proteostasis and Interactome as part of general Biochemistry research is frequently linked to DNAJC19, Barth syndrome and Tafazzin, bridging the gap between disciplines. Her Proteostasis research includes themes of Protein subunit and Mitochondrial permeability transition pore. Her mitochondrial fusion research is multidisciplinary, incorporating elements of Axoplasmic transport, Inner mitochondrial membrane, Mitochondrial Size, Spinocerebellar ataxia and Kinase.
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Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1
Sarah Ehses;Ines Raschke;Giuseppe Mancuso;Andrea Bernacchia.
Journal of Cell Biology (2009)
The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission
Ruchika Anand;Timothy Wai;Michael J. Baker;Nikolay Kladt.
Journal of Cell Biology (2014)
The m-AAA Protease Defective in Hereditary Spastic Paraplegia Controls Ribosome Assembly in Mitochondria
Mark Nolden;Sarah Ehses;Mirko Koppen;Andrea Bernacchia.
Mitochondrial quality control: a matter of life and death for neurons
Elena I Rugarli;Thomas Langer;Thomas Langer.
The EMBO Journal (2012)
Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport
Fatima Ferreirinha;Angelo Quattrini;Marinella Pirozzi;Valentina Valsecchi.
Journal of Clinical Investigation (2004)
Opitz G/BBB syndrome, a defect of midline development, is due to mutations in a new RING finger gene on Xp22
Nandita A. Quaderi;Susann Schweiger;Karin Gaudenz;Brunella Franco.
Nature Genetics (1997)
Spastin, the protein mutated in autosomal dominant hereditary spastic paraplegia, is involved in microtubule dynamics
Alessia Errico;Andrea Ballabio;Elena I. Rugarli.
Human Molecular Genetics (2002)
Variable and Tissue-Specific Subunit Composition of Mitochondrial m-AAA Protease Complexes Linked to Hereditary Spastic Paraplegia
Mirko Koppen;Metodi D. Metodiev;Giorgio Casari;Elena I. Rugarli.
Molecular and Cellular Biology (2007)
OPA1 Processing Reconstituted in Yeast Depends on the Subunit Composition of the m-AAA Protease in Mitochondria
Stéphane Duvezin-Caubet;Mirko Koppen;Johannes Wagener;Michael Zick.
Molecular Biology of the Cell (2007)
Expression pattern of the Kallmann syndrome gene in the olfactory system suggests a role in neuronal targeting
Elena I. Rugarli;Beat Lutz;Shigeru C. Kuratani;Stefan Wawersik.
Nature Genetics (1993)
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