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Hiroshi Nakanishi

Hiroshi Nakanishi

D-Index & Metrics

Neuroscience

D-Index
63
Citations
11289
World Ranking
3442
National Ranking
97

Overview

Hiroshi Nakanishi is affiliated with Yasuda Women's University in Japan and has contributed extensively to the fields of neuroscience, biochemistry, genetics, molecular biology, and medicine. Their research primarily focuses on neurology, molecular biology, immunology, periodontics, and cognitive neuroscience.

The main topics covered in their work include:

  • Neuroinflammation and neurodegeneration mechanisms
  • Immune response and inflammation
  • Hearing, cochlea, tinnitus, and genetics
  • Oral microbiology and periodontitis research
  • Hearing loss and rehabilitation
  • Noise effects and management
  • Connexins and lens biology

Recent publications by Hiroshi Nakanishi include:

  • "Secreted gingipains from Porphyromonas gingivalis increase permeability in human cerebral microvascular endothelial cells through intracellular degradation of tight junction proteins," 2022, Neurochemistry International
  • "Extralysosomal cathepsin B in central nervous system: Mechanisms and therapeutic implications," 2022, Brain Pathology
  • "Microglial circadian clock regulation of microglial structural complexity, dendritic spine density and inflammatory response," 2020, Neurochemistry International
  • "Update on Findings about Sudden Sensorineural Hearing Loss and Insight into Its Pathogenesis," 2022, Journal of Clinical Medicine
  • "Long non-coding RNA ELDR enhances oral cancer growth by promoting ILF3-cyclin E1 signaling," 2020, EMBO Reports

Frequent co-authors collaborating with Nakanishi include:

  • Saori Nonaka
  • Junjun Ni
  • Zhou Wu
  • Sachi Shimizu
  • Sayaka Miyamoto

Popular venues for publishing their research have been:

  • Neurochemistry International
  • Preprints.org
  • Auris Nasus Larynx
  • Brain Pathology
  • Journal of Clinical Medicine

Best Publications

  • AMPA-Kainate Subtypes of Glutamate Receptor in Rat Cerebral Microglia

    Mami Noda;Hiroshi Nakanishi;Junichi Nabekura;Norio Akaike

  • Intracellular study of rat substantia nigra pars reticulata neurons in an in vitro slice preparation: electrical membrane properties and response characteristics to subthalamic stimulation

    H. Nakanishi;Hitoshi Kita;S. T. Kitai

  • Age-Related Changes in Activities and Localizations of Cathepsins D, E, B, and L in the Rat Brain Tissues

    Hiroshi Nakanishi;Kazuyoshi Tominaga;Tutomu Amano;Ichirou Hirotsu

  • Electrical membrane properties of rat subthalamic neurons in an in vitro slice preparation.

    H. Nakanishi;Hitoshi Kita;S. T. Kitai

  • Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice.

    Yoshinori Hayashi;Masayoshi Yoshida;Mayumi Yamato;Tomomi Ide

  • Cathepsin B plays a critical role in inducing Alzheimer’s disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice

    Zhou Wu;Junjun Ni;Yicong Liu;Jessica L. Teeling

  • TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia.

    Kiyoto Kurima;Seham Ebrahim;Bifeng Pan;Miloslav Sedlacek

  • Microglial functions and proteases

    Hiroshi Nakanishi

  • Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice

    Masato Koike;Masahiro Shibata;Yoshiyuki Ohsawa;Hiroshi Nakanishi

  • Glutamate release from microglia via glutamate transporter is enhanced by amyloid-beta peptide

    M. Noda;H. Nakanishi;N. Akaike

  • Microglia-aging: Roles of microglial lysosome- and mitochondria-derived reactive oxygen species in brain aging

    Hiroshi Nakanishi;Zhou Wu

  • The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S

    Yoshinori Hayashi;Satoru Koyanagi;Naoki Kusunose;Ryo Okada

  • Neuronal and microglial cathepsins in aging and age-related diseases

    Hiroshi Nakanishi

  • Age-dependent neuroinflammatory responses and deficits in long-term potentiation in the hippocampus during systemic inflammation.

    X. Liu;Z. Wu;Y. Hayashi;H. Nakanishi

  • Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice.

    Hiroshi Nakanishi;Jian Zhang;Masato Koike;Tsuyoshi Nishioku

  • Increased Expression of Cathepsins E and D in Neurons of the Aged Rat Brain and Their Colocalization with Lipofuscin and Carboxy‐Terminal Fragments of Alzheimer Amyloid Precursor Protein

    Hiroshi Nakanishi;Tutomu Amano;Dewi Fatma Suniarti Sastradipura;Yoshito Yoshimine

  • The Critical Role of Proteolytic Relay through Cathepsins B and E in the Phenotypic Change of Microglia/Macrophage.

    Junjun Ni;Zhou Wu;Christoph Peterts;Kenji Yamamoto

  • Leptomeningeal cells activate microglia and astrocytes to induce IL-10 production by releasing pro-inflammatory cytokines during systemic inflammation.

    Zhou Wu;Jian Zhang;Hiroshi Nakanishi

  • Involvement of Cathepsin E in Exogenous Antigen Processing in Primary Cultured Murine Microglia

    Tsuyoshi Nishioku;Koichi Hashimoto;Keizo Yamashita;Shyh Yuh Liou

  • Microglial Ca(2+)-activated K(+) channels are possible molecular targets for the analgesic effects of S-ketamine on neuropathic pain.

    Yoshinori Hayashi;Kodai Kawaji;Li Sun;Xinwen Zhang

  • Involvement of cathepsin B in the processing and secretion of interleukin‐1β in chromogranin A‐stimulated microglia

    Kayo Terada;Jun Yamada;Yoshinori Hayashi;Zhou Wu

  • Proteases involved in long-term potentiation.

    Yoshiro Tomimatsu;Satoru Idemoto;Shigeki Moriguchi;Shigenori Watanabe

Frequent Co-Authors

Shigenori Watanabe
Shigenori Watanabe Kyushu University
Hitoshi Kita
Hitoshi Kita University of Tennessee Health Science Center
Kazuhide Inoue
Kazuhide Inoue Kyushu University
Shigenobu Shibata
Shigenobu Shibata Waseda University
Michihiro Fujiwara
Michihiro Fujiwara Fukuoka University
Shinichi Kohsaka
Shinichi Kohsaka Keio University
Jun-ichi Kira
Jun-ichi Kira Kyushu University
Robert K. P. Sullivan
Robert K. P. Sullivan University of Queensland
Takaomi C. Saido
Takaomi C. Saido RIKEN Center for Brain Science
Mami Noda
Mami Noda Kyushu University

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