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Frank C. P. Holstege

Frank C. P. Holstege

Utrecht University
Netherlands

D-Index & Metrics

Discipline name D-Index World Ranking Current World Ranking National Ranking Current National Ranking Publications Citations
Genetics 77 1761 1675 60 59 196 25325

Frank C. P. Holstege publications per year

The chart shows the history of publications by Frank C. P. Holstege between 1990 and 2025, highlighting the no. of papers published in each year and offering an overview of the publication velocity of this scholar. Frank C. P. Holstege published across 36 years, from 1990 to 2025, averaging 8.3 papers a year. Output peaked at 81 publications in 2023. 6 of the 300 publications appeared in the last two years.

No. of publications
20 40 60 80
Bar chart. Horizontal axis: year, 1990 to 2025. Vertical axis: number of publications, 0 to 81. Peak 81 publications in 2023. 1990: 2 publications 1991: 3 publications 1992: 1 publication 1993: 0 publications 1994: 1 publication 1995: 1 publication 1996: 1 publication 1997: 2 publications 1998: 1 publication 1999: 5 publications 2000: 3 publications 2001: 5 publications 2002: 4 publications 2003: 5 publications 2004: 9 publications 2005: 10 publications 2006: 6 publications 2007: 8 publications 2008: 9 publications 2009: 10 publications 2010: 3 publications 2011: 9 publications 2012: 15 publications 2013: 24 publications 2014: 10 publications 2015: 7 publications 2016: 3 publications 2017: 5 publications 2018: 5 publications 2019: 6 publications 2020: 12 publications 2021: 13 publications 2022: 15 publications 2023: 81 publications 2024: 5 publications 2025: 1 publication
1990 2025

300 publications in total across all disciplines

View publications per year as a table
Frank C. P. Holstege: publications per year, 1990 to 2025
Year Publications
1990 2
1991 3
1992 1
1993 0
1994 1
1995 1
1996 1
1997 2
1998 1
1999 5
2000 3
2001 5
2002 4
2003 5
2004 9
2005 10
2006 6
2007 8
2008 9
2009 10
2010 3
2011 9
2012 15
2013 24
2014 10
2015 7
2016 3
2017 5
2018 5
2019 6
2020 12
2021 13
2022 15
2023 81
2024 5
2025 1
Total 300
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Frank C. P. Holstege publication distribution in Genetics in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Genetics in 2026. The highlighted bar marks where Frank C. P. Holstege sits on this spectrum.

No. of scientists
50 100 150 200
Bar chart with 67 bars. Horizontal axis: publications, 45–54 to 703+. Vertical axis: number of scientists, 0 to 217. Most scientists, 217, have 125–134 publications. The last bar groups every scientist with 703 publications or more. The highlighted bar, 195–204 publications, is where this scientist sits. 45–54 publications: 6 scientists 55–64 publications: 10 scientists 65–74 publications: 35 scientists 75–84 publications: 84 scientists 85–94 publications: 102 scientists 95–104 publications: 151 scientists 105–114 publications: 175 scientists 115–124 publications: 203 scientists 125–134 publications: 217 scientists 135–144 publications: 205 scientists 145–154 publications: 193 scientists 155–164 publications: 188 scientists 165–174 publications: 170 scientists 175–184 publications: 178 scientists 185–194 publications: 164 scientists 195–204 publications: 173 scientists 205–214 publications: 159 scientists 215–224 publications: 134 scientists 225–234 publications: 143 scientists 235–244 publications: 105 scientists 245–254 publications: 114 scientists 255–264 publications: 92 scientists 265–274 publications: 88 scientists 275–284 publications: 87 scientists 285–294 publications: 80 scientists 295–304 publications: 62 scientists 305–314 publications: 75 scientists 315–324 publications: 67 scientists 325–334 publications: 60 scientists 335–344 publications: 52 scientists 345–354 publications: 40 scientists 355–364 publications: 48 scientists 365–374 publications: 47 scientists 375–384 publications: 46 scientists 385–394 publications: 31 scientists 395–404 publications: 27 scientists 405–414 publications: 40 scientists 415–424 publications: 30 scientists 425–434 publications: 43 scientists 435–444 publications: 29 scientists 445–454 publications: 14 scientists 455–464 publications: 28 scientists 465–474 publications: 21 scientists 475–484 publications: 21 scientists 485–494 publications: 22 scientists 495–504 publications: 17 scientists 505–514 publications: 12 scientists 515–524 publications: 11 scientists 525–534 publications: 8 scientists 535–544 publications: 8 scientists 545–554 publications: 14 scientists 555–564 publications: 4 scientists 565–574 publications: 11 scientists 575–584 publications: 5 scientists 585–594 publications: 11 scientists 595–604 publications: 12 scientists 605–614 publications: 7 scientists 615–624 publications: 6 scientists 625–634 publications: 10 scientists 635–644 publications: 9 scientists 645–654 publications: 10 scientists 655–664 publications: 6 scientists 665–674 publications: 6 scientists 675–684 publications: 6 scientists 685–694 publications: 4 scientists 695–702 publications: 6 scientists 703+ publications: 100 scientists
45–54 publications 703+

This scientist: 196 publications — 49th percentile

49% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 703 publications or more.

View publications distribution as a table
Number of Genetics scientists by publication count, Research.com 2026 ranking edition. Based on 4,342 ranked scientists.
Publications Scientists This scientist
45–54 6
55–64 10
65–74 35
75–84 84
85–94 102
95–104 151
105–114 175
115–124 203
125–134 217
135–144 205
145–154 193
155–164 188
165–174 170
175–184 178
185–194 164
195–204 173 196
205–214 159
215–224 134
225–234 143
235–244 105
245–254 114
255–264 92
265–274 88
275–284 87
285–294 80
295–304 62
305–314 75
315–324 67
325–334 60
335–344 52
345–354 40
355–364 48
365–374 47
375–384 46
385–394 31
395–404 27
405–414 40
415–424 30
425–434 43
435–444 29
445–454 14
455–464 28
465–474 21
475–484 21
485–494 22
495–504 17
505–514 12
515–524 11
525–534 8
535–544 8
545–554 14
555–564 4
565–574 11
575–584 5
585–594 11
595–604 12
605–614 7
615–624 6
625–634 10
635–644 9
645–654 10
655–664 6
665–674 6
675–684 6
685–694 4
695–702 6
703+ 100
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Frank C. P. Holstege D-index placement in Genetics in 2026

The chart shows the D-index (discipline H-index) distribution of Genetics scientists ranked by Research.com in 2026. The highlighted bar marks where Frank C. P. Holstege sits on this spectrum.

No. of scientists
50 100 150
Bar chart with 61 bars. Horizontal axis: D-Index, 40–41 to 160+. Vertical axis: number of scientists, 0 to 191. Most scientists, 191, have 62–63 D-Index. The last bar groups every scientist with 160 D-Index or more. The highlighted bar, 76–77 D-Index, is where this scientist sits. 40–41 D-Index: 24 scientists 42–43 D-Index: 52 scientists 44–45 D-Index: 84 scientists 46–47 D-Index: 112 scientists 48–49 D-Index: 118 scientists 50–51 D-Index: 141 scientists 52–53 D-Index: 143 scientists 54–55 D-Index: 145 scientists 56–57 D-Index: 179 scientists 58–59 D-Index: 162 scientists 60–61 D-Index: 175 scientists 62–63 D-Index: 191 scientists 64–65 D-Index: 172 scientists 66–67 D-Index: 184 scientists 68–69 D-Index: 164 scientists 70–71 D-Index: 158 scientists 72–73 D-Index: 150 scientists 74–75 D-Index: 136 scientists 76–77 D-Index: 127 scientists 78–79 D-Index: 127 scientists 80–81 D-Index: 111 scientists 82–83 D-Index: 110 scientists 84–85 D-Index: 110 scientists 86–87 D-Index: 84 scientists 88–89 D-Index: 102 scientists 90–91 D-Index: 66 scientists 92–93 D-Index: 72 scientists 94–95 D-Index: 70 scientists 96–97 D-Index: 54 scientists 98–99 D-Index: 60 scientists 100–101 D-Index: 49 scientists 102–103 D-Index: 55 scientists 104–105 D-Index: 45 scientists 106–107 D-Index: 42 scientists 108–109 D-Index: 28 scientists 110–111 D-Index: 39 scientists 112–113 D-Index: 25 scientists 114–115 D-Index: 31 scientists 116–117 D-Index: 29 scientists 118–119 D-Index: 34 scientists 120–121 D-Index: 29 scientists 122–123 D-Index: 29 scientists 124–125 D-Index: 18 scientists 126–127 D-Index: 27 scientists 128–129 D-Index: 22 scientists 130–131 D-Index: 16 scientists 132–133 D-Index: 11 scientists 134–135 D-Index: 17 scientists 136–137 D-Index: 12 scientists 138–139 D-Index: 21 scientists 140–141 D-Index: 4 scientists 142–143 D-Index: 9 scientists 144–145 D-Index: 14 scientists 146–147 D-Index: 6 scientists 148–149 D-Index: 10 scientists 150–151 D-Index: 7 scientists 152–153 D-Index: 9 scientists 154–155 D-Index: 8 scientists 156–157 D-Index: 8 scientists 158–159 D-Index: 9 scientists 160+ D-Index: 96 scientists
40–41 D-Index 160+

This scientist: 77 D-Index — 60th percentile

60% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 160 D-Index or more.

View D-Index distribution as a table
Number of Genetics scientists by D-index, Research.com 2026 ranking edition. Based on 4,342 ranked scientists.
D-Index Scientists This scientist
40–41 24
42–43 52
44–45 84
46–47 112
48–49 118
50–51 141
52–53 143
54–55 145
56–57 179
58–59 162
60–61 175
62–63 191
64–65 172
66–67 184
68–69 164
70–71 158
72–73 150
74–75 136
76–77 127 77
78–79 127
80–81 111
82–83 110
84–85 110
86–87 84
88–89 102
90–91 66
92–93 72
94–95 70
96–97 54
98–99 60
100–101 49
102–103 55
104–105 45
106–107 42
108–109 28
110–111 39
112–113 25
114–115 31
116–117 29
118–119 34
120–121 29
122–123 29
124–125 18
126–127 27
128–129 22
130–131 16
132–133 11
134–135 17
136–137 12
138–139 21
140–141 4
142–143 9
144–145 14
146–147 6
148–149 10
150–151 7
152–153 9
154–155 8
156–157 8
158–159 9
160+ 96
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Overview

Frank C. P. Holstege is affiliated with Utrecht University in the Netherlands. Their research spans several fields related to biochemistry, genetics, molecular biology, and medicine. The scientist has a focus on more specialized areas such as molecular biology, oncology, pulmonary and respiratory medicine, cancer research, and neurology.

The main topics covered in Holstege's work include:

  • Cancer Genomics and Diagnostics
  • Renal and related cancers
  • Neuroblastoma Research and Treatments
  • Sarcoma Diagnosis and Treatment
  • CAR-T cell therapy research
  • Genomics and Chromatin Dynamics
  • Renal cell carcinoma treatment

Holstege has published extensively, with frequent contributions to specific scientific venues. The top publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Nature Communications
  • Cell stem cell
  • European Journal of Cancer

The following list includes recent representative publications, featuring the full title, year, and the venue where they appeared:

  • An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity, 2020, Nature Communications
  • Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell, 2021, Science Advances
  • Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation, 2022, Cell stem cell
  • Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype, 2021, Proceedings of the National Academy of Sciences
  • Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy, 2024, Cancer Cell

Several frequent collaborators appear alongside Holstege's work, reflecting ongoing research partnerships. These co-authors include:

  • Patrick Kemmeren
  • Thanasis Margaritis
  • Jarno Drost
  • Jan J. Molenaar
  • Bastiaan B.J. Tops

Best Publications

  • Minimum information about a microarray experiment (MIAME)-toward standards for microarray data.

    Alvis Brazma;Pascal Hingamp;John Quackenbush;Gavin Sherlock

  • Dissecting the regulatory circuitry of a eukaryotic genome

    Frank Holstege;Richard Young

  • Toward a Comprehensive Atlas of the Physical Interactome of Saccharomyces cerevisiae

    Sean R. Collins;Sean R. Collins;Patrick Kemmeren;Patrick Kemmeren;Xue-Chu Zhao;Jack F. Greenblatt

  • Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector.

    Marc van de Wetering;Irma Oving;Vanesa Muncan;Menno Tjon Pon Fong

  • An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas.

    Paul Roepman;Lodewyk F A Wessels;Lodewyk F A Wessels;Nienke Kettelarij;Patrick Kemmeren

  • Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast

    John J. Wyrick;Frank C.P. Holstege;Ezra G. Jennings;Helen C. Causton

  • Redundant roles for the TFIID and SAGA complexes in global transcription

    Tong Ihn Lee;Helen C. Causton;Frank C. P. Holstege;Frank C. P. Holstege;Wu-Cheng Shen

  • Opening of an RNA polymerase II promoter occurs in two distinct steps and requires the basal transcription factors IIE and IIH.

    F. C. P. Holstege;P. C. Van Der Vliet;H. T. M. Timmers

  • Tubuloids derived from human adult kidney and urine for personalized disease modeling

    Frans Schutgens;Frans Schutgens;Maarten B Rookmaaker;Thanasis Margaritis;Anne Rios

  • Uterine Selection of Human Embryos at Implantation

    Jan J. Brosens;Madhuri S. Salker;Gijs Teklenburg;Jaya Nautiyal

  • A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.

    Henri Marc Bourbon;Andres Aguilera;Aseem Z. Ansari;Francisco J. Asturias

  • Large-Scale Genetic Perturbations Reveal Regulatory Networks and an Abundance of Gene-Specific Repressors

    Patrick Kemmeren;Katrin Sameith;Loes A L. van de Pasch;Joris Joris J Benschop

  • Functional Organization of the S. cerevisiae Phosphorylation Network

    Dorothea Fiedler;Dorothea Fiedler;Hannes Braberg;Monika Mehta;Gal Chechik

  • Three transitions in the RNA polymerase II transcription complex during initiation

    Frank C. P. Holstege;Ulrike Fiedler;H. Th. Marc Timmers

  • Protein interaction verification and functional annotation by integrated analysis of genome-scale data.

    Patrick Kemmeren;Patrick Kemmeren;Nynke L. van Berkum;Jaak Vilo;Theo Bijma

  • Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy

    Kristan E. van der Vos;Pernilla Eliasson;Tassula Proikas-Cezanne;Stephin J. Vervoort;Stephin J. Vervoort

  • A high resolution protein interaction map of the yeast Mediator complex

    Benjamin Guglielmi;Nynke L. van Berkum;Benjamin Klapholz;Theo Bijma

  • The Specificity and Topology of Chromatin Interaction Pathways in Yeast

    Tineke L. Lenstra;Joris J. Benschop;Tae Soo Kim;Julia M. Schulze

  • Mediator Expression Profiling Epistasis Reveals a Signal Transduction Pathway with Antagonistic Submodules and Highly Specific Downstream Targets

    Jeroen van de Peppel;Nienke Kettelarij;Harm van Bakel;Thessa T.J.P. Kockelkorn

  • Genome-wide analyses reveal RNA polymerase II located upstream of genes poised for rapid response upon S. cerevisiae stationary phase exit.

    Marijana Radonjic;Jean-Christophe Andrau;Philip Lijnzaad;Patrick Kemmeren

Frequent Co-Authors

Marian J. A. Groot Koerkamp
Marian J. A. Groot Koerkamp Princess Máxima Center
Marten P. Smidt
Marten P. Smidt University of Amsterdam
Richard A. Young
Richard A. Young MIT
Nevan J. Krogan
Nevan J. Krogan University of California, San Francisco
Hans Clevers
Hans Clevers Hubrecht Institute for Developmental Biology and Stem Cell Research
Harm van Bakel
Harm van Bakel Icahn School of Medicine at Mount Sinai
Alvis Brazma
Alvis Brazma European Bioinformatics Institute
Nick S. Macklon
Nick S. Macklon University of Copenhagen
John Quackenbush
John Quackenbush Harvard University
Cisca Wijmenga
Cisca Wijmenga University Medical Center Groningen

External Links

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Best Scientists Citing Frank C. P. Holstege

Nevan J. Krogan

Nevan J. Krogan

University of California, San Francisco

Publications: 76

Patrick Cramer

Patrick Cramer

Max Planck Society

Publications: 51

Alvis Brazma

Alvis Brazma

European Bioinformatics Institute

Publications: 49

Joan Weliky Conaway

Joan Weliky Conaway

The University of Texas Southwestern Medical Center

Publications: 48

Jan J. Brosens

Jan J. Brosens

University of Warwick

Publications: 48

Jean-Marc Egly

Jean-Marc Egly

Institute of Genetics and Molecular and Cellular Biology

Publications: 39

John P. A. Ioannidis

John P. A. Ioannidis

Stanford University

Publications: 39

Jack Greenblatt

Jack Greenblatt

University of Toronto

Publications: 38

Helen Parkinson

Helen Parkinson

European Bioinformatics Institute

Publications: 36

Stephen G. Oliver

Stephen G. Oliver

University of Cambridge

Publications: 36

Jerry L. Workman

Jerry L. Workman

Stowers Institute for Medical Research

Publications: 35

Ronald C. Conaway

Ronald C. Conaway

The University of Texas Southwestern Medical Center

Publications: 35

Hans Clevers

Hans Clevers

Hubrecht Institute for Developmental Biology and Stem Cell Research

Publications: 33

Steven Hahn

Steven Hahn

Fred Hutchinson Cancer Research Center

Publications: 33

Kevin Struhl

Kevin Struhl

Harvard University

Publications: 32

John Quackenbush

John Quackenbush

Harvard University

Publications: 31

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