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Frank C. P. Holstege

Frank C. P. Holstege

D-Index & Metrics

Genetics

D-Index
77
Citations
25325
World Ranking
1761
National Ranking
60

Overview

Frank C. P. Holstege is affiliated with Utrecht University in the Netherlands. Their research spans several fields related to biochemistry, genetics, molecular biology, and medicine. The scientist has a focus on more specialized areas such as molecular biology, oncology, pulmonary and respiratory medicine, cancer research, and neurology.

The main topics covered in Holstege's work include:

  • Cancer Genomics and Diagnostics
  • Renal and related cancers
  • Neuroblastoma Research and Treatments
  • Sarcoma Diagnosis and Treatment
  • CAR-T cell therapy research
  • Genomics and Chromatin Dynamics
  • Renal cell carcinoma treatment

Holstege has published extensively, with frequent contributions to specific scientific venues. The top publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Nature Communications
  • Cell stem cell
  • European Journal of Cancer

The following list includes recent representative publications, featuring the full title, year, and the venue where they appeared:

  • An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity, 2020, Nature Communications
  • Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell, 2021, Science Advances
  • Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation, 2022, Cell stem cell
  • Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype, 2021, Proceedings of the National Academy of Sciences
  • Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy, 2024, Cancer Cell

Several frequent collaborators appear alongside Holstege's work, reflecting ongoing research partnerships. These co-authors include:

  • Patrick Kemmeren
  • Thanasis Margaritis
  • Jarno Drost
  • Jan J. Molenaar
  • Bastiaan B.J. Tops

Best Publications

  • Minimum information about a microarray experiment (MIAME)-toward standards for microarray data.

    Alvis Brazma;Pascal Hingamp;John Quackenbush;Gavin Sherlock

  • Dissecting the regulatory circuitry of a eukaryotic genome

    Frank Holstege;Richard Young

  • Toward a Comprehensive Atlas of the Physical Interactome of Saccharomyces cerevisiae

    Sean R. Collins;Sean R. Collins;Patrick Kemmeren;Patrick Kemmeren;Xue-Chu Zhao;Jack F. Greenblatt

  • Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector.

    Marc van de Wetering;Irma Oving;Vanesa Muncan;Menno Tjon Pon Fong

  • An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas.

    Paul Roepman;Lodewyk F A Wessels;Lodewyk F A Wessels;Nienke Kettelarij;Patrick Kemmeren

  • Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast

    John J. Wyrick;Frank C.P. Holstege;Ezra G. Jennings;Helen C. Causton

  • Redundant roles for the TFIID and SAGA complexes in global transcription

    Tong Ihn Lee;Helen C. Causton;Frank C. P. Holstege;Frank C. P. Holstege;Wu-Cheng Shen

  • Opening of an RNA polymerase II promoter occurs in two distinct steps and requires the basal transcription factors IIE and IIH.

    F. C. P. Holstege;P. C. Van Der Vliet;H. T. M. Timmers

  • Tubuloids derived from human adult kidney and urine for personalized disease modeling

    Frans Schutgens;Frans Schutgens;Maarten B Rookmaaker;Thanasis Margaritis;Anne Rios

  • Uterine Selection of Human Embryos at Implantation

    Jan J. Brosens;Madhuri S. Salker;Gijs Teklenburg;Jaya Nautiyal

  • A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.

    Henri Marc Bourbon;Andres Aguilera;Aseem Z. Ansari;Francisco J. Asturias

  • Large-Scale Genetic Perturbations Reveal Regulatory Networks and an Abundance of Gene-Specific Repressors

    Patrick Kemmeren;Katrin Sameith;Loes A L. van de Pasch;Joris Joris J Benschop

  • Functional Organization of the S. cerevisiae Phosphorylation Network

    Dorothea Fiedler;Dorothea Fiedler;Hannes Braberg;Monika Mehta;Gal Chechik

  • Three transitions in the RNA polymerase II transcription complex during initiation

    Frank C. P. Holstege;Ulrike Fiedler;H. Th. Marc Timmers

  • Protein interaction verification and functional annotation by integrated analysis of genome-scale data.

    Patrick Kemmeren;Patrick Kemmeren;Nynke L. van Berkum;Jaak Vilo;Theo Bijma

  • Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy

    Kristan E. van der Vos;Pernilla Eliasson;Tassula Proikas-Cezanne;Stephin J. Vervoort;Stephin J. Vervoort

  • A high resolution protein interaction map of the yeast Mediator complex

    Benjamin Guglielmi;Nynke L. van Berkum;Benjamin Klapholz;Theo Bijma

  • The Specificity and Topology of Chromatin Interaction Pathways in Yeast

    Tineke L. Lenstra;Joris J. Benschop;Tae Soo Kim;Julia M. Schulze

  • Mediator Expression Profiling Epistasis Reveals a Signal Transduction Pathway with Antagonistic Submodules and Highly Specific Downstream Targets

    Jeroen van de Peppel;Nienke Kettelarij;Harm van Bakel;Thessa T.J.P. Kockelkorn

  • Genome-wide analyses reveal RNA polymerase II located upstream of genes poised for rapid response upon S. cerevisiae stationary phase exit.

    Marijana Radonjic;Jean-Christophe Andrau;Philip Lijnzaad;Patrick Kemmeren

Frequent Co-Authors

Marian J. A. Groot Koerkamp
Marian J. A. Groot Koerkamp Princess Máxima Center
Marten P. Smidt
Marten P. Smidt University of Amsterdam
Nevan J. Krogan
Nevan J. Krogan University of California, San Francisco
Hans Clevers
Hans Clevers Hubrecht Institute for Developmental Biology and Stem Cell Research
Harm van Bakel
Harm van Bakel Icahn School of Medicine at Mount Sinai
Alvis Brazma
Alvis Brazma European Bioinformatics Institute
Nick S. Macklon
Nick S. Macklon University of Copenhagen
John Quackenbush
John Quackenbush Harvard University
Cisca Wijmenga
Cisca Wijmenga University Medical Center Groningen

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