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Immunology

D-Index
58
Citations
11685
World Ranking
3529
National Ranking
1633

Overview

Neil E. Alexis is affiliated with the University of North Carolina at Chapel Hill in the United States. The research conducted by Alexis deeply engages with pulmonary and respiratory medicine, with a strong interdisciplinary focus incorporating environmental science and health toxicology.

Their work spans several main fields of study, notably:

  • Medicine
  • Environmental Science

and key subfields including:
  • Pulmonary and Respiratory Medicine
  • Health, Toxicology and Mutagenesis
  • Physiology
  • Immunology
  • Molecular Biology

The primary topics of their research cover a diverse array of respiratory health impacts and environmental factors:

  • Air Quality and Health Impacts
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Asthma and respiratory diseases
  • Climate Change and Health Impacts
  • Medical and Biological Ozone Research
  • Air Quality Monitoring and Forecasting
  • Smoking Behavior and Cessation

Neil E. Alexis has contributed extensively to scientific literature, with key recent publications including:

  • Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort, 2021, The Lancet Respiratory Medicine
  • Lung Microbiota and Metabolites Collectively Associate with Clinical Outcomes in Milder Stage Chronic Obstructive Pulmonary Disease, 2022, American Journal of Respiratory and Critical Care Medicine
  • Expanded characterization of in vitro polarized M0, M1, and M2 human monocyte-derived macrophages: Bioenergetic and secreted mediator profiles, 2023, PLoS ONE
  • A Network of Sputum MicroRNAs Is Associated with Neutrophilic Airway Inflammation in Asthma, 2020, American Journal of Respiratory and Critical Care Medicine
  • Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort, 2021, npj Biofilms and Microbiomes

The venues where Neil E. Alexis frequently publishes reflect a consistent focus on respiratory and biomedical research:

  • UNC Libraries
  • American Journal of Respiratory and Critical Care Medicine
  • Harvard Dataverse
  • CHEST Journal
  • PLoS ONE

Collaboration is evident in Alexis's work, with frequent co-authors including:

  • Christopher B. Cooper
  • Nadia N. Hansel
  • Prescott G. Woodruff
  • Alejandro P. Comellas
  • David B. Peden

Best Publications

  • Health effects of air pollution

    Jonathan A. Bernstein;Neil Alexis;Charles Barnes;I. Leonard Bernstein

  • The health effects of nonindustrial indoor air pollution

    Jonathan A. Bernstein;Neil E Alexis;Hyacinth Bacchus;I. Leonard Bernstein

  • Airway Mucin Concentration as a Marker of Chronic Bronchitis.

    Mehmet Kesimer;Amina A. Ford;Agathe Ceppe;Giorgia Radicioni

  • E-Cigarette Use Causes a Unique Innate Immune Response in the Lung, Involving Increased Neutrophilic Activation and Altered Mucin Secretion

    Boris Reidel;Giorgia Radicioni;Phillip W. Clapp;Amina A. Ford

  • Frequency of exacerbations in patients with chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort

    MeiLan K Han;Pedro M Quibrera;Elizabeth E Carretta;R Graham Barr

  • Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort.

    Annette T Hastie;Fernando J Martinez;Jeffrey L Curtis;Claire M Doerschuk

  • Chronic E-Cigarette Exposure Alters the Human Bronchial Epithelial Proteome

    Arunava Ghosh;Raymond C. Coakley;Teresa Mascenik;Temperance R. Rowell

  • Lung Function and Inflammatory Responses in Healthy Young Adults Exposed to 0.06 ppm Ozone for 6.6 Hours

    Chong S. Kim;Neil E. Alexis;Ana G. Rappold;Howard Kehrl

  • A work group report on ultrafine particles (American Academy of Allergy, Asthma & Immunology): Why ambient ultrafine and engineered nanoparticles should receive special attention for possible adverse health outcomes in human subjects

    Ning Li;Steve Georas;Neil Alexis;Patricia Fritz

  • A Biophysical Basis for Mucus Solids Concentration as a Candidate Biomarker for Airways Disease

    David B Hill;Paula A. Vasquez;John Mellnik;Scott A. McKinley

  • Chronic E-Cigarette Use Increases Neutrophil Elastase and Matrix Metalloprotease Levels in the Lung

    Arunava Ghosh;Raymond D. Coakley;Andrew J. Ghio;Marianne S. Muhlebach

  • Biological material on inhaled coarse fraction particulate matter activates airway phagocytes in vivo in healthy volunteers.

    Neil E. Alexis;John C. Lay;Kirby Zeman;William E. Bennett

  • Coarse particulate matter (PM2.5-10) affects heart rate variability, blood lipids, and circulating eosinophils in adults with asthma.

    Karin Yeatts;Erik Svendsen;John Creason;Neil E. Alexis

  • SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans

    Aili L. Lazaar;Lisa E. Sweeney;Alexander J. MacDonald;Neil E. Alexis

  • Induced sputum derives from the central airways: confirmation using a radiolabeled aerosol bolus delivery technique.

    Neil E. Alexis;Shu Chieh Hu;Kirby Zeman;Todd Alter

  • The Relationship of Mucus Concentration (Hydration) to Mucus Osmotic Pressure and Transport in Chronic Bronchitis

    Wayne H. Anderson;Raymond D. Coakley;Brian Button;Ashley G. Henderson

  • Different expression ratio of S100A8/A9 and S100A12 in acute and chronic lung diseases.

    Eva Lorenz;Marianne S. Muhlebach;Philippe A. Tessier;Neil E. Alexis

  • Diesel exhaust augments allergen-induced lower airway inflammation in allergic individuals: a controlled human exposure study

    Chris Carlsten;Anders Blomberg;Mandy Pui;Thomas Sandstrom

  • Sputum phagocytes from healthy individuals are functional and activated: a flow cytometric comparison with cells in bronchoalveolar lavage and peripheral blood.

    Neil E Alexis;Joleen Soukup;Andrew Ghio;Susanne Becker

  • CD14-dependent airway neutrophil response to inhaled LPS: role of atopy.

    Neil Alexis;Marlowe Eldridge;William Reed;Philip Bromberg

  • Exposures of Healthy and Asthmatic Volunteers to Concentrated Ambient Ultrafine Particles in Los Angeles

    Henry Gong;William S. Linn;Kenneth W. Clark;Karen R. Anderson

  • Climate Change and Our Environment: The Effect on Respiratory and Allergic Disease

    Charles S. Barnes;Neil E. Alexis;Jonathan A. Bernstein;John R. Cohn

  • Association between airway hyperreactivity and bronchial macrophage dysfunction in individuals with mild asthma

    Neil E. Alexis;Joleen Soukup;Stefan Nierkens;Susanne Becker

Frequent Co-Authors

David B. Peden
David B. Peden University of North Carolina at Chapel Hill
Wanda K. O'Neal
Wanda K. O'Neal University of North Carolina at Chapel Hill
Fernando J. Martinez
Fernando J. Martinez University of Massachusetts Chan Medical School
Nadia N. Hansel
Nadia N. Hansel Johns Hopkins University
Jeffrey L. Curtis
Jeffrey L. Curtis University of Michigan–Ann Arbor
Eric A. Hoffman
Eric A. Hoffman University of Iowa
Prescott G. Woodruff
Prescott G. Woodruff University of California, San Francisco
Jerry A. Krishnan
Jerry A. Krishnan University of Illinois at Chicago
Mark T. Dransfield
Mark T. Dransfield University of Alabama at Birmingham
Eugene R. Bleecker
Eugene R. Bleecker University of Arizona

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