World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
67
Citations
17127
World Ranking
8167
National Ranking
3693

Overview

Jack R. Harkema is affiliated with Michigan State University in the United States. Their research spans multiple disciplines within medicine and environmental science, with a primary focus on health impacts related to toxicology, immunology, and respiratory medicine.

The scientist's fields of study include:

  • Medicine
  • Environmental Science

Their subfields of study are specialized in areas such as:

  • Health, Toxicology and Mutagenesis
  • Immunology
  • Pulmonary and Respiratory Medicine
  • Infectious Diseases
  • Nutrition and Dietetics

Key research topics covered by Jack R. Harkema include:

  • Air Quality and Health Impacts
  • Climate Change and Health Impacts
  • Systemic Lupus Erythematosus Research
  • Fatty Acid Research and Health
  • Asthma and respiratory diseases
  • Eicosanoids and Hypertension Pharmacology
  • SARS-CoV-2 and COVID-19 Research

Recent publications provide insight into the breadth of their work:

  • Outdoor Air Pollution and New-Onset Airway Disease. An Official American Thoracic Society Workshop Report (2020), published in Annals of the American Thoracic Society
  • Arsenic and benzo[a]pyrene co-exposure acts synergistically in inducing cancer stem cell-like property and tumorigenesis by epigenetically down-regulating SOCS3 expression (2020), published in Environment International
  • Omega-3 fatty acid intake suppresses induction of diverse autoantibody repertoire by crystalline silica in lupus-prone mice (2020), published in Autoimmunity
  • Neuroinflammatory and Neurometabolomic Consequences From Inhaled Wildfire Smoke-Derived Particulate Matter in the Western United States (2021), published in Toxicological Sciences
  • Rapid Induction of Pulmonary Inflammation, Autoimmune Gene Expression, and Ectopic Lymphoid Neogenesis Following Acute Silica Exposure in Lupus-Prone Mice (2021), published in Frontiers in Immunology

Frequent co-authors in their publications include:

  • James G. Wagner
  • James J. Pestka
  • Ryan P. Lewandowski
  • Kathryn A. Wierenga
  • Abby D. Benninghoff

Jack R. Harkema regularly publishes in venues such as:

  • UNC Libraries
  • Frontiers in Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Particle and Fibre Toxicology
  • Toxicological Sciences

Best Publications

  • Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice.

    Marcus Mall;Barbara R Grubb;Jack R Harkema;Wanda K O'Neal

  • Ambient Particulate Pollutants in the Ultrafine Range Promote Early Atherosclerosis and Systemic Oxidative Stress

    Jesus A. Araujo;Berenice Barajas;Michael Kleinman;Xuping Wang

  • The Nose Revisited: A Brief Review of the Comparative Structure, Function, and Toxicologic Pathology of the Nasal Epithelium

    Jack R. Harkema;Stephan A. Carey;James G. Wagner

  • Proliferative and nonproliferative lesions of the rat and mouse respiratory tract.

    Roger Renne;Amy Brix;Jack Harkema;Ron Herbert

  • Vaccine Efficacy in Senescent Mice Challenged with Recombinant SARS-CoV Bearing Epidemic and Zoonotic Spike Variants

    Damon Deming;Timothy Sheahan;Mark Heise;Boyd Yount

  • Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology.

    Alison Elder;Robert Gelein;Jacob N. Finkelstein;Kevin E. Driscoll

  • Air pollution-mediated susceptibility to inflammation and insulin resistance: influence of CCR2 pathways in mice.

    Cuiqing Liu;Xiaohua Xu;Yuntao Bai;Tse Yao Wang

  • The Adjuvant Effect of Ambient Particulate Matter Is Closely Reflected by the Particulate Oxidant Potential

    Ning Li;Meiying Wang;Lori A. Bramble;Debra A. Schmitz

  • Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues

    Zhaobin Xu;Zhaobin Xu;Xiaohua Xu;Mianhua Zhong;Ian P. Hotchkiss

  • Long-term exposure to concentrated ambient PM2.5 increases mouse blood pressure through abnormal activation of the sympathetic nervous system: a role for hypothalamic inflammation.

    Zhekang Ying;Xiaohua Xu;Yuntao Bai;Jixin Zhong

  • Temporal and Dose-Dependent Hepatic Gene Expression Patterns in Mice Provide New Insights into TCDD-Mediated Hepatotoxicity

    Darrell R. Boverhof;Lyle D. Burgoon;Colleen Tashiro;Brock Chittim

  • Development of Chronic Bronchitis and Emphysema in β-Epithelial Na+ Channel–Overexpressing Mice

    Marcus A. Mall;Jack R. Harkema;Joanna B. Trojanek;Diana Treis

  • Reduced metabolic insulin sensitivity following sub-acute exposures to low levels of ambient fine particulate matter air pollution.

    Robert D. Brook;Xiaohua Xu;Robert L. Bard;J. Timothy Dvonch

  • Linkage analysis of susceptibility to ozone-induced lung inflammation in inbred mice

    Steven R. Kleeberger;Roy C. Levitt;Liu Yi Zhang;Malinda Longphre

  • Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice.

    Darrell R. Boverhof;Lyle D. Burgoon;Colleen Tashiro;Bonnie Sharratt

  • CD36-Dependent 7-Ketocholesterol Accumulation in Macrophages Mediates Progression of Atherosclerosis in Response to Chronic Air Pollution Exposure

    Xiaoquan Rao;Jixin Zhong;Andrei Maiseyeu;Bhavani Gopalakrishnan

  • Nanotoxicology--a pathologist's perspective.

    Ann F. Hubbs;Robert R. Mercer;Stanley A. Benkovic;Jack Harkema

  • Comparative aspects of nasal airway anatomy: relevance to inhalation toxicology.

    Jack R. Harkema

  • Production of Interferon-γ by Influenza Hemagglutinin-Specific CD8 Effector T Cells Influences the Development of Pulmonary Immunopathology

    James A. Wiley;Adelheid Cerwenka;Jack R. Harkema;Richard W. Dutton

  • Epidemiological and Experimental Links between Air Pollution and Type 2 Diabetes

    Cuiqing Liu;Zhekang Ying;Jack Harkema;Qinghua Sun

Frequent Co-Authors

James J. Pestka
James J. Pestka Michigan State University
Sanjay Rajagopalan
Sanjay Rajagopalan Case Western Reserve University
Robert D. Brook
Robert D. Brook University of Michigan–Ann Arbor
Gerald J. Keeler
Gerald J. Keeler University of Michigan–Ann Arbor
Timothy R. Zacharewski
Timothy R. Zacharewski Michigan State University
J. Timothy Dvonch
J. Timothy Dvonch University of Michigan–Ann Arbor
Norbert E. Kaminski
Norbert E. Kaminski Michigan State University
Andrij Holian
Andrij Holian University of Montana
David B. Peden
David B. Peden University of North Carolina at Chapel Hill
Joe L. Mauderly
Joe L. Mauderly Lovelace Respiratory Research Institute

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