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Timothy R. Zacharewski

Timothy R. Zacharewski

Michigan State University
United States

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
15165
World Ranking
8701
National Ranking
3903

Timothy R. Zacharewski publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Timothy R. Zacharewski sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 191 publications — 46th percentile

46% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Timothy R. Zacharewski D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Timothy R. Zacharewski sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 66 D-Index — 57th percentile

57% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Timothy R. Zacharewski is affiliated with Michigan State University in the United States. Their research primarily focuses on Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions to subfields such as Molecular Biology, Physiology, Oncology, Health, Toxicology and Mutagenesis, and Epidemiology.

The scientist's body of work addresses several main topics, including:

  • Adipose Tissue and Metabolism
  • Metabolomics and Mass Spectrometry Studies
  • Toxic Organic Pollutants Impact
  • Liver Disease Diagnosis and Treatment
  • Drug Transport and Resistance Mechanisms
  • Alcohol Consumption and Health Effects
  • Epigenetics and DNA Methylation

Recent notable publications by Timothy R. Zacharewski include:

  • "Thioesterase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin results in a futile cycle that inhibits hepatic β-oxidation" (2021) published in Scientific Reports
  • "Aryl Hydrocarbon Receptor (AhR) Activation by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Dose-Dependently Shifts the Gut Microbiome Consistent with the Progression of Non-Alcoholic Fatty Liver Disease" (2021) published in International Journal of Molecular Sciences
  • "Genome-wide ChIPseq analysis of AhR, COUP-TF, and HNF4 enrichment in TCDD-treated mouse liver" (2021) published in bioRxiv (Cold Spring Harbor Laboratory)
  • "Characterizing the impact of simvastatin co-treatment of cell specific TCDD-induced gene expression and systemic toxicity" (2023) published in Scientific Reports
  • "Generative Deep Learning of the Single Cell Dose Response of 2,3,7,8 Tetrachlorodibenzo- p -dioxin in Mouse Liver" (2022) published in The FASEB Journal

Timothy R. Zacharewski has frequently published in Scientific Reports and bioRxiv (Cold Spring Harbor Laboratory), contributing multiple papers to each venue. Other publication venues include the International Journal of Molecular Sciences, The FASEB Journal, and the Journal of Pharmacology and Experimental Therapeutics.

Frequent co-authors collaborating with them include:

  • Rance Nault
  • Russell R. Fling
  • Giovan N. Cholico
  • Jack R. Harkema
  • Omar Kana

The research conducted by Timothy R. Zacharewski emphasizes elucidating molecular and biochemical mechanisms involved in toxicology and metabolic diseases, with specific studies on the effects of dioxin compounds and their impact on liver metabolism, gut microbiome shifts, and gene expression regulation related to toxicity and disease progression.

Best Publications

  • Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently

    Mark Leid;Mark Leid;Philippe Kastner;Philippe Kastner;Ruth Lyons;Ruth Lyons;Harikrishna Nakshatri;Harikrishna Nakshatri

  • Bisphenol A interacts with the estrogen receptor α in a distinct manner from estradiol

    Janet C. Gould;Linda S. Leonard;Susan C. Maness;Brandee L. Wagner

  • NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-butyl phthalate ☆

    Robert Kavlock;Kim Boekelheide;Robert Chapin;Michael Cunningham

  • In vitro and in vivo interactions of bisphenol A and its metabolite, bisphenol A glucuronide, with estrogen receptors alpha and beta.

    Jason B. Matthews;Ken Twomey;Timothy R. Zacharewski

  • Overview of a workshop on screening methods for detecting potential (anti‐) estrogenic/androgenic chemicals in wildlife

    Gerald T. Ankley;Ellen Mihaich;Ralph G. Stahl;Donald E. Tillitt

  • 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin (TCDD) and Related Compounds as Antioestrogens: Characterization and Mechanism of Action

    S. Safe;B. Astroff;M. Harris;T. Zacharewski

  • Differential estrogen receptor binding of estrogenic substances: a species comparison.

    Jason Matthews;Trine Celius;Robert Halgren;Tim Zacharewski

  • Hydroxylated polychlorinated biphenyls (PCBs) as estrogens and antiestrogens: structure-activity relationships.

    K. Connor;K. Ramamoorthy;M. Moore;M. Mustain

  • Endocrine Screening Methods Workshop report: detection of estrogenic and androgenic hormonal and antihormonal activity for chemicals that act via receptor or steroidogenic enzyme mechanisms.

    L.Earl Gray;William R. Kelce;Tom Wiese;Rochelle Tyl

  • Activity of Benzo[a]pyrene and Its Hydroxylated Metabolites in an Estrogen Receptor-α Reporter Gene Assay

    Grantley D. Charles;Michael J. Bartels;Timothy R. Zacharewski;B. Bhaskar Gollapudi

  • Antiestrogenic activity of hydroxylated polychlorinated biphenyl congeners identified in human serum.

    M Moore;M Mustain;K Daniel;I Chen

  • Temporal and Dose-Dependent Hepatic Gene Expression Patterns in Mice Provide New Insights into TCDD-Mediated Hepatotoxicity

    Darrell R. Boverhof;Lyle D. Burgoon;Colleen Tashiro;Brock Chittim

  • Challenges and Limitations of Gene Expression Profiling in Mechanistic and Predictive Toxicology

    Mark R. Fielden;Tim R. Zacharewski

  • Exoestrogens: Mechanisms of action and strategies for identification and assessment

    Bradley E. Gillesby;Timothy R. Zacharewski;Timothy R. Zacharewski

  • Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice.

    Darrell R. Boverhof;Lyle D. Burgoon;Colleen Tashiro;Bonnie Sharratt

  • NTP center for the evaluation of risks to human reproduction

    Robert Kavlock;Kim Boekelheide;Robert Chapin;Michael Cunningham

  • Toxicogenomics in risk assessment : Applications and needs

    Darrell R. Boverhof;Timothy R. Zacharewski

  • Naringenin: a weakly estrogenic bioflavonoid that exhibits antiestrogenic activity

    Mary F. Ruh;Timothy Zacharewski;Kevin Connor;James Howell

  • Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: Effects on enzyme induction and immunotoxicity

    R. Bannister;D. Davis;T. Zacharewski;I. Tizard

  • Failure of chloro-S-triazine-derived compounds to induce estrogen receptor-mediated responses in vivo and in vitro.

    K. Connor;J. Howell;I. Chen;H. Liu

Frequent Co-Authors

Jack R. Harkema
Jack R. Harkema Michigan State University
Norbert E. Kaminski
Norbert E. Kaminski Michigan State University
Melvin E. Andersen
Melvin E. Andersen Research Triangle Park Foundation
Geoffrey L. Hammond
Geoffrey L. Hammond University of British Columbia
Paige L. Williams
Paige L. Williams Harvard University
Ilpo Huhtaniemi
Ilpo Huhtaniemi Imperial College London
John P. Giesy
John P. Giesy University of Saskatchewan
A. Daniel Jones
A. Daniel Jones Michigan State University
Kim Boekelheide
Kim Boekelheide Brown University
Robert E. Chapin
Robert E. Chapin Pfizer (United States)

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Best Scientists Citing Timothy R. Zacharewski

John P. Giesy

John P. Giesy

University of Saskatchewan

Publications: 49

Paul C. Boutros

Paul C. Boutros

University of California, Los Angeles

Publications: 34

Antonia M. Calafat

Antonia M. Calafat

Centers for Disease Control and Prevention

Publications: 32

Nancy D. Denslow

Nancy D. Denslow

University of Florida

Publications: 28

Jodi A. Flaws

Jodi A. Flaws

University of Illinois at Urbana-Champaign

Publications: 27

Norbert E. Kaminski

Norbert E. Kaminski

Michigan State University

Publications: 24

Holger M. Koch

Holger M. Koch

Ruhr University Bochum

Publications: 22

Larry W. Robertson

Larry W. Robertson

University of Iowa

Publications: 21

Gerald T. Ankley

Gerald T. Ankley

Environmental Protection Agency

Publications: 19

Robert Barouki

Robert Barouki

Université Paris Cité

Publications: 18

Carole L. Yauk

Carole L. Yauk

University of Ottawa

Publications: 18

Allan B. Okey

Allan B. Okey

University of Toronto

Publications: 17

Charles R. Tyler

Charles R. Tyler

University of Exeter

Publications: 16

Gary H. Perdew

Gary H. Perdew

Pennsylvania State University

Publications: 16

Patrick Balaguer

Patrick Balaguer

University of Montpellier

Publications: 15

Henner Hollert

Henner Hollert

Goethe University Frankfurt

Publications: 15

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