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Microbiology

D-Index
41
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7034
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5429
National Ranking
2051

Overview

Gale Smith is affiliated with Novavax in the United States and has contributed extensively to research in infectious diseases, particularly focusing on SARS-CoV-2 and COVID-19. Their work spans multiple subfields including epidemiology, animal science and zoology, immunology, and molecular biology, reflecting a comprehensive approach to understanding viral infections and immune responses.

The primary topics of Gale Smith's research include:

  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Animal Virus Infections Studies
  • Influenza Virus Research Studies
  • Viral gastroenteritis research and epidemiology
  • Immunotherapy and Immune Responses
  • Respiratory viral infections research

Recent publications highlight Smith's involvement in vaccine development and immunogenicity studies. Notable papers include:

  • "Phase 1-2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine" (2020), published in the New England Journal of Medicine
  • "SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice" (2021), published in Nature Communications
  • "SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral spike vaccines" (2021), published in Cell Host & Microbe
  • "Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate" (2020), published in Science
  • "NVX-CoV2373 vaccine protects cynomolgus macaque upper and lower airways against SARS-CoV-2 challenge" (2020), published in Vaccine

Smith frequently collaborates with several researchers, with the most common coauthors being Nita Patel, Gregory M. Glenn, Mimi Guebre-Xabier, Bin Zhou, and Michael J. Massare. This network indicates a strong collaborative environment in the field of vaccine research and virus immunology.

The scientist's publications are predominantly found in several key venues known for infectious disease and vaccine research, including bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Vaccine, Vaccines, and the New England Journal of Medicine.

With over 100 publications in the medical field and a notable emphasis on infectious diseases, Smith's work contributes to the understanding of viral infection mechanisms and vaccine efficacy. Their research addresses both preclinical and clinical aspects of viral immunogenicity and vaccine development, particularly targeting the SARS-CoV-2 virus and its variants.

Best Publications

  • SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice.

    Jing Hui Tian;Nita Patel;Robert Haupt;Haixia Zhou

  • Influenza virus-like particles comprised of the HA, NA, and M1 proteins of H9N2 influenza virus induce protective immune responses in BALB/c mice.

    Peter Pushko;Terrence M. Tumpey;Fang Bu;John Knell

  • Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate.

    Sandhya Bangaru;Gabriel Ozorowski;Hannah L Turner;Aleksandar Antanasijevic

  • SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral spike vaccines.

    Xiaoying Shen;Haili Tang;Charlene McDanal;Kshitij Wagh

  • Influenza virus-like particles elicit broader immune responses than whole virion inactivated influenza virus or recombinant hemagglutinin.

    Rick A. Bright;Donald M. Carter;Shannon Daniluk;Franklin R. Toapanta

  • Purified coronavirus Spike protein nanoparticles induce coronavirus neutralizing antibodies in mice

    Christopher M. Coleman;Ye V. Liu;Haiyan Mu;Justin K. Taylor

  • Cross-Clade Protective Immune Responses to Influenza Viruses with H5N1 HA and NA Elicited by an Influenza Virus-Like Particle

    Rick A. Bright;Donald M. Carter;Corey J. Crevar;Franklin R. Toapanta

  • Baculovirus-derived hemagglutinin vaccines protect against lethal influenza infections by avian H5 and H7 subtypes.

    John Crawford;Bethanie Wilkinson;Andrei Vosnesensky;Gale Smith

  • The Safety and Immunogenicity of a Human Immunodeficiency Virus Type 1 (HIV-1) Recombinant gp160 Candidate Vaccine in Humans

    Raphael Dolin;Barney S. Graham;Stephen B. Greenberg;Carol O. Tacket

  • Respiratory syncytial virus fusion glycoprotein expressed in insect cells form protein nanoparticles that induce protective immunity in cotton rats.

    Gale Smith;Rama Raghunandan;Yingyun Wu;Ye Liu

  • A Randomized, Blinded, Controlled, Dose-Ranging Study of a Respiratory Syncytial Virus Recombinant Fusion (F) Nanoparticle Vaccine in Healthy Women of Childbearing Age

    Gregory M. Glenn;Louis F. Fries;D. Nigel Thomas;Gale Smith

  • Induction of CD4+ human cytolytic T cells specific for HIV-infected cells by a gp160 subunit vaccine

    Rimas J. Orentas;James E K Hildreth;Eugene Obah;Michael J Polydefkis

  • Safety and immunogenicity of a Sf9 insect cell-derived respiratory syncytial virus fusion protein nanoparticle vaccine

    Gregory M. Glenn;Gale Smith;Louis Fries;Rama Raghunandan

  • Newcastle disease virus-like particles containing respiratory syncytial virus G protein induced protection in BALB/c mice, with no evidence of immunopathology.

    Matthew R. Murawski;Lori W. McGinnes;Robert W. Finberg;Evelyn A. Kurt-Jones

  • Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine in a blinded, randomized, placebo-controlled trial of adults in Mexico.

    Constantino López-Macías;Eduardo Ferat-Osorio;Alejandra Tenorio-Calvo;Alejandra Tenorio-Calvo;Armando Isibasi

  • Intranasal Vaccination with 1918 Influenza Virus-Like Particles Protects Mice and Ferrets from Lethal 1918 and H5N1 Influenza Virus Challenge

    Lucy A. Perrone;Attiya Ahmad;Vic Veguilla;Xiuhua Lu

  • Pharmacological administration of granulocyte/macrophage-colony-stimulating factor is of significant importance for the induction of a strong humoral and cellular response in patients immunized with recombinant carcinoembryonic antigen.

    Ali Samanci;Qing Yi;Jan Fagerberg;Karin Strigård

  • Development of influenza H7N9 virus like particle (VLP) vaccine: homologous A/Anhui/1/2013 (H7N9) protection and heterologous A/chicken/Jalisco/CPA1/2012 (H7N3) cross-protection in vaccinated mice challenged with H7N9 virus.

    Gale E. Smith;David C. Flyer;Ramadevi Raghunandan;Ye Liu

  • Assembly and Immunological Properties of Newcastle Disease Virus-Like Particles Containing the Respiratory Syncytial Virus F and G Proteins

    Lori W. McGinnes;Kathryn A. Gravel;Robert W. Finberg;Evelyn A. Kurt-Jones

  • Matrix-M adjuvant enhances antibody, cellular and protective immune responses of a Zaire Ebola/Makona virus glycoprotein (GP) nanoparticle vaccine in mice.

    Karin Lövgren Bengtsson;Haifeng Song;Linda Stertman;Ye Liu

  • Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination.

    Matthew J. Gorman;Nita Patel;Mimi Guebre-Xabier;Alex L. Zhu;Alex L. Zhu

  • SARS-CoV-2 Variant B.1.1.7 is Susceptible to Neutralizing Antibodies Elicited by Ancestral Spike Vaccines

    Xiaoying Shen;Haili Tang;Charlene McDanal;Kshitij Wagh

Frequent Co-Authors

L F Fries
L F Fries Novavax (United States)
Matthew B. Frieman
Matthew B. Frieman University of Maryland, Baltimore
David C. Montefiori
David C. Montefiori Duke University
Terrence M. Tumpey
Terrence M. Tumpey Centers for Disease Control and Prevention
Richard W. Compans
Richard W. Compans Emory University
Pedro A. Piedra
Pedro A. Piedra Baylor College of Medicine
Jay W. Hooper
Jay W. Hooper United States Department of the Army
Fatima Amanat
Fatima Amanat Icahn School of Medicine at Mount Sinai

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