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D-Index & Metrics

Biology and Biochemistry

D-Index
67
Citations
14011
World Ranking
8316
National Ranking
3755

Overview

Thomas R. Kleyman is affiliated with the University of Pittsburgh in the United States and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. Their work spans numerous subfields, including molecular biology, endocrinology, diabetes and metabolism, nutrition and dietetics, physiology, and pulmonary and respiratory medicine.

The scientist's research topics focus primarily on ion transport and channel regulation, hormonal regulation and hypertension, ion channel regulation and function, and sodium intake and health. Additional areas of investigation include electrolyte and hormonal disorders, renal and related cancers, and erythrocyte function and pathophysiology.

Thomas R. Kleyman has a selection of recent papers published in distinguished venues. Notable publications include:

  • Hypertension (2021), published in Circulation Research
  • Epithelial Sodium Channel and Salt-Sensitive Hypertension (2021), published in Hypertension
  • DC ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension (2022), published in Circulation Research
  • ENaC in Salt-Sensitive Hypertension: Kidney and Beyond (2020), published in Current Hypertension Reports
  • Intercalated cell BKα subunit is required for flow-induced K+ secretion (2020), published in JCI Insight

Some of the frequent coauthors collaborating with Thomas R. Kleyman include Annet Kirabo, Stephanie M. Mutchler, Evan C. Ray, Allison L. Marciszyn, and Shaohu Sheng. These collaborations highlight a consistent research network centered on topics related to ion channels and hypertension.

The researcher often publishes in venues such as The FASEB Journal, Journal of the American Society of Nephrology, Physiology, American Journal of Physiology-Renal Physiology, and Physiological Reports. These journals reflect the interdisciplinary nature of their studies, bridging molecular biology, physiology, and clinical medicine.

Best Publications

  • Amiloride and its analogs as tools in the study of ion transport.

    Thomas R. Kleyman;Edward J. Cragoe;Edward J. Cragoe

  • Epithelial Sodium Channels Are Activated by Furin-dependent Proteolysis

    Rebecca P. Hughey;James B. Bruns;Carol L. Kinlough;Keri L. Harkleroad

  • Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit.

    James B. Bruns;Marcelo D. Carattino;Shaohu Sheng;Ahmad B. Maarouf

  • ENaC at the Cutting Edge: Regulation of Epithelial Sodium Channels by Proteases

    Thomas R. Kleyman;Marcelo D. Carattino;Rebecca P. Hughey

  • Maturation of the Epithelial Na+ Channel Involves Proteolytic Processing of the α- and γ-Subunits

    Rebecca P. Hughey;Gunhild M. Mueller;James B. Bruns;Carol L. Kinlough

  • Flow-dependent K+ secretion in the cortical collecting duct is mediated by a maxi-K channel.

    Craig B. Woda;Alvina Bragin;Thomas R. Kleyman;Lisa M. Satlin

  • Subunit Stoichiometry of the Epithelial Sodium Channel

    Farhad Kosari;Shaohu Sheng;Jinqing Li;Don On D. Mak

  • Epithelial Na(+) channels are regulated by flow.

    Lisa M. Satlin;Shaohu Sheng;Craig B. Woda;Thomas R. Kleyman

  • Aldosterone alters the open probability of amiloride-blockable sodium channels in A6 epithelia.

    A. E. Kemendy;T. R. Kleyman;D. C. Eaton

  • Plasmin Activates Epithelial Na+ Channels by Cleaving the γ Subunit

    Christopher J. Passero;Gunhild M. Mueller;Helbert Rondon-Berrios;Stevan P. Tofovic

  • Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition

    Shaohu Sheng;Marcelo D. Carattino;James B. Bruns;Rebecca P. Hughey

  • Differential effects of Hsc70 and Hsp70 on the intracellular trafficking and functional expression of epithelial sodium channels

    Samuel B. Goldfarb;Ossama B. Kashlan;Jeffrey N. Watkins;Laurence Suaud

  • Distinct Pools of Epithelial Sodium Channels Are Expressed at the Plasma Membrane

    Rebecca P. Hughey;James B. Bruns;Carol L. Kinlough;Thomas R. Kleyman

  • Epithelial Na+ Channels Are Activated by Laminar Shear Stress

    Marcelo D. Carattino;Shaohu Sheng;Thomas R. Kleyman

  • Brief report: trimethoprim-induced hyperkalemia in a patient with AIDS.

    Michael J. Choi;Pedro C. Fernandez;Pedro C. Fernandez;Pedro C. Fernandez;Asit Patnaik;Brigitte Coupaye-Gerard

  • Epithelial Sodium Channel Inhibition by AMP-activated Protein Kinase in Oocytes and Polarized Renal Epithelial Cells

    Marcelo D. Carattino;Robert S. Edinger;Heather J. Grieser;Rosalee Wise

  • ENaC structure and function in the wake of a resolved structure of a family member.

    Ossama B. Kashlan;Thomas R. Kleyman

  • Role of epithelial sodium channels and their regulators in hypertension

    Rama Soundararajan;David Pearce;Rebecca P. Hughey;Thomas R. Kleyman

  • Airway Surface Liquid Volume Regulates ENaC by Altering the Serine Protease-Protease Inhibitor Balance A MECHANISM FOR SODIUM HYPERABSORPTION IN CYSTIC FIBROSIS

    Mike M. Myerburg;Michael B. Butterworth;Erin E. McKenna;Kathryn W. Peters

  • Proteolytic Processing of the Epithelial Sodium Channel γ Subunit Has a Dominant Role in Channel Activation

    Marcelo D. Carattino;Rebecca P. Hughey;Thomas R. Kleyman

Frequent Co-Authors

Thomas Kieber-Emmons
Thomas Kieber-Emmons University of Arkansas for Medical Sciences
Joseph M. Pilewski
Joseph M. Pilewski University of Pittsburgh
Douglas C. Eaton
Douglas C. Eaton Emory University
J. Kevin Foskett
J. Kevin Foskett University of Pennsylvania
Bruce A. Molitoris
Bruce A. Molitoris Indiana University
Uwe Schlattner
Uwe Schlattner Grenoble Alpes University
Gerard Apodaca
Gerard Apodaca University of Pittsburgh
Horacio F. Cantiello
Horacio F. Cantiello Harvard University
James D. Stockand
James D. Stockand The University of Texas Health Science Center at San Antonio
David Pearce
David Pearce Northumbria University

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