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Biology and Biochemistry

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Medicine

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Overview

Sadis Matalon is affiliated with the University of Alabama at Birmingham in the United States, specializing in research that intersects medicine and biochemistry, genetics, and molecular biology. Their scientific work predominantly addresses pulmonary and respiratory medicine, molecular biology, epidemiology, health toxicology and mutagenesis, and infectious diseases.

Their research topics cover a range of areas including neonatal respiratory health research, heme oxygenase-1 and carbon monoxide, proteoglycans and glycosaminoglycans, respiratory viral infections, SARS-CoV-2 and COVID-19, ion channel regulation and function, and the neuroscience of respiration and sleep.

Sadis Matalon has contributed to a number of publications in high-impact journals. Notable recent papers include:

  • "Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility," 2020, Physiological Reviews
  • "Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report," 2022, American Journal of Respiratory Cell and Molecular Biology
  • "SARS-CoV-2 may regulate cellular responses through depletion of specific host miRNAs," 2020, American Journal of Physiology-Lung Cellular and Molecular Physiology
  • "AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme oxygenase-1," 2021, European Respiratory Journal
  • "Reactive species generated by heme impair alveolar epithelial sodium channel function in acute respiratory distress syndrome," 2020, Redox Biology

They regularly publish in several journals where their work appears multiple times, including:

  • American Journal of Physiology-Lung Cellular and Molecular Physiology
  • Redox Biology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Physiological Reviews
  • Zenodo (CERN European Organization for Nuclear Research)

Their frequent collaborators include Tamás Jilling, Ahmed Lazrak, Zhihong Yu, Israr Ahmad, and Saurabh Aggarwal, each co-authoring multiple publications. This network reflects a sustained collaborative effort in respiratory and molecular biology research.

Matalon's contributions focus on critical areas such as the mechanisms underlying acute lung injury, molecular regulators of respiratory function, and viral infection responses, highlighting intersections between molecular pathways and respiratory health outcomes.

Best Publications

  • Quantitation of nitrotyrosine levels in lung sections of patients and animals with acute lung injury.

    I. Y. Haddad;G. Pataki;Ping Hu;C. Galliani

  • Future research directions in acute lung injury: Summary of a National Heart, Lung, and Blood Institute Working Group

    Michael A. Matthay;Guy A. Zimmerman;Charles Esmon;Jahar Bhattacharya

  • Oxidant-antioxidant balance in acute lung injury.

    John D. Lang;Philip J. McArdle;Philip J. O'Reilly;Sadis Matalon

  • Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility.

    Hong Long Ji;Runzhen Zhao;Sadis Matalon;Michael A. Matthay

  • Mechanisms of peroxynitrite-induced injury to pulmonary surfactants

    I. Y. Haddad;H. Ischiropoulos;B. A. Holm;J. S. Beckman

  • Sodium channels in alveolar epithelial cells: molecular characterization, biophysical properties, and physiological significance.

    Sadis Matalon;Hugh O'Brodovich

  • Nitric Oxide and Nitrotyrosine in the Lungs of Patients with Acute Respiratory Distress Syndrome

    Chanchai Sittipunt;Kenneth P. Steinberg;John T. Ruzinski;Carpantato Myles

  • Tumor necrosis factor and interleukin 1 alpha increase vascular endothelial permeability

    J. A. Royall;R. L. Berkow;J. S. Beckman;M. K. Cunningham

  • Participation of miR-200 in pulmonary fibrosis.

    Shanzhong Yang;Sami Banerjee;Andressa de Freitas;Yan Y. Sanders

  • Concurrent generation of nitric oxide and superoxide damages surfactant protein A.

    I. Y. Haddad;J. P. Crow;P. Hu;Y. Ye

  • Increased levels of nitrate and surfactant protein a nitration in the pulmonary edema fluid of patients with acute lung injury.

    Sha Zhu;Lorraine B. Ware;Thomas Geiser;Michael A. Matthay

  • Pulmonary physiological and surfactant changes during injury and recovery from hyperoxia.

    B. A. Holm;R. H. Notter;J. Siegle;S. Matalon

  • TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury.

    Shrilatha Balakrishna;Weifeng Song;Satyanarayana Achanta;Stephen F. Doran

  • Biophysical and molecular properties of amiloride-inhibitable Na+ channels in alveolar epithelial cells.

    Sadis Matalon;Dale J. Benos;Robert M. Jackson

  • Nitric oxide inhibits Na+absorption across cultured alveolar type II monolayers

    Yi Guo;Michael D. Duvall;John P. Crow;Sadis Matalon

  • Cigarette smoke and CFTR: implications in the pathogenesis of COPD

    Andras Rab;Steven M. Rowe;S. Vamsee Raju;Zsuzsa Bebok

  • Liver ischemia-reperfusion increases pulmonary permeability in rat: Role of circulating xanthine oxidase

    A. Weinbroum;V. G. Nielsen;S. Tan;S. Gelman

  • Biochemical characterization of human S-nitrosohemoglobin. Effects on oxygen binding and transnitrosation.

    Rakesh P. Patel;Neil Hogg;Netanya Y. Spencer;B. Kalyanaraman

  • Peroxynitrite inhibition of oxygen consumption and sodium transport in alveolar type II cells.

    P. Hu;H. Ischiropoulos;J. S. Beckman;S. Matalon

  • Increased expression and activity of sodium channels in alveolar type II cells of hyperoxic rats

    Gang Yue;William J. Russell;William J. Russell;Dale J. Benos;Dale J. Benos;Robert M. Jackson;Robert M. Jackson

Frequent Co-Authors

James F. Collawn
James F. Collawn University of Alabama at Birmingham
Giuseppe L. Squadrito
Giuseppe L. Squadrito University of Alabama at Birmingham
Dale J. Benos
Dale J. Benos University of Alabama at Birmingham
Chad Steele
Chad Steele Tulane University
Joseph S. Beckman
Joseph S. Beckman Oregon State University
Eric J. Sorscher
Eric J. Sorscher Emory University
Kenneth B. Adler
Kenneth B. Adler North Carolina State University
Namasivayam Ambalavanan
Namasivayam Ambalavanan University of Alabama at Birmingham
Bruce A. Freeman
Bruce A. Freeman University of Pittsburgh
Gang Liu
Gang Liu University of Alabama at Birmingham

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