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Biology and Biochemistry

D-Index
56
Citations
10994
World Ranking
14457
National Ranking
6082

Overview

James F. Collawn is affiliated with the University of Alabama at Birmingham in the United States. Their work spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with significant contributions focused on cellular and molecular mechanisms related to disease and hypoxia.

The scientist has published extensively in various journals, including Cellular & Molecular Biology Letters, Cancers, Zenodo (CERN European Organization for Nuclear Research), Cell Communication and Signaling, and Research Square. Their research often addresses complex cellular responses under hypoxic conditions, molecular regulation related to cancer, and RNA-associated processes.

Among recent papers authored or co-authored by Collawn are:

  • Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia, 2020, Cellular & Molecular Biology Letters
  • The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability, 2022, Cellular & Molecular Biology Letters
  • SARS-CoV-2 may regulate cellular responses through depletion of specific host miRNAs, 2020, American Journal of Physiology-Lung Cellular and Molecular Physiology
  • The hypoxia-induced changes in miRNA-mRNA in RNA-induced silencing complexes and HIF-2 induced miRNAs in human endothelial cells, 2022, The FASEB Journal
  • Hypoxia-inducible factor (HIF)-3α2 serves as an endothelial cell fate executor during chronic hypoxia, 2021, PubMed

Frequent co-authors in Collawn's research include Rafał Bartoszewski, Sylwia Bartoszewska, Magdalena Gebert, Michał Dąbrowski, and Jakub Sławski, highlighting collaborative work mainly in molecular biology and hypoxia-related studies.

The main fields of study for Collawn's work are:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Subfields prominently featured in their publications comprise:

  • Molecular Biology
  • Cancer Research
  • Cell Biology
  • Epidemiology
  • Genetics

The core topics explored by James F. Collawn include:

  • Endoplasmic Reticulum Stress and Disease
  • Cancer, Hypoxia, and Metabolism
  • MicroRNA in disease regulation
  • RNA modifications and cancer
  • Autophagy in Disease and Therapy
  • Extracellular vesicles in disease
  • Cancer-related molecular mechanisms research

This overview reflects an emphasis on molecular pathways regulating cellular adaptation under stress conditions such as low oxygen availability, cancer progression, and RNA-based regulatory mechanisms. Collawn's research contributes to a broader understanding of how molecular interactions influence disease states and cellular fate decisions.

Best Publications

  • Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway

    I S Trowbridge;J F Collawn;C R Hopkins

  • Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis

    James F. Collawn;Martin Stangel;Leslie A. Kuhn;Victor Esekogwu

  • Identification of the Transferrin Receptor as a Novel Immunoglobulin (Ig)a1 Receptor and Its Enhanced Expression on Mesangial Cells in Iga Nephropathy

    Ivan C. Moura;Miguel N. Centelles;Michelle Arcos-Fajardo;Denise M. Malheiros

  • Behavior of glycopolypeptides with empirical molecular weight estimation methods. 1. In sodium dodecyl sulfate

    Bonnie Strayer Leach;James F. Collawn;Wayne W. Fish

  • PDZ domain interaction controls the endocytic recycling of the cystic fibrosis transmembrane conductance regulator.

    Agnieszka Swiatecka-Urban;Marc Duhaime;Bonita Coutermarsh;Katherine H. Karlson

  • miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target.

    Marcin Serocki;Sylwia Bartoszewska;Anna Janaszak-Jasiecka;Renata J. Ochocka

  • A Synonymous Single Nucleotide Polymorphism in ΔF508 CFTR Alters the Secondary Structure of the mRNA and the Expression of the Mutant Protein

    Rafal A. Bartoszewski;Michael Jablonsky;Sylwia Bartoszewska;Lauren Stevenson

  • Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment.

    C. G. Odorizzi;I. S. Trowbridge;Luzheng Xue;C. R. Hopkins

  • Failure of cAMP agonists to activate rescued ΔF508 CFTR in CFBE41o– airway epithelial monolayers

    Zsuzsa Bebok;James F. Collawn;John Wakefield;William Parker

  • Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors.

    C P Chang;C S Lazar;B J Walsh;M Komuro

  • Syntaxin 1A inhibits CFTR chloride channels by means of domain-specific protein–protein interactions

    Anjaparavanda P. Naren;Michael W. Quick;James F. Collawn;Deborah J. Nelson

  • Purification and macromolecular properties of a sialic acid-specific lectin from the slug Limax flavus.

    R L Miller;J F Collawn;W W Fish

  • SNPs in microRNA target sites and their potential role in human disease.

    Adrianna Moszyńska;Magdalena Gebert;James F. Collawn;Rafał Bartoszewski

  • Efficient intracellular processing of the endogenous cystic fibrosis transmembrane conductance regulator in epithelial cell lines.

    Károly Varga;Asta Jurkuvenaite;John Wakefield;Jeong S. Hong

  • Cigarette smoke and CFTR: implications in the pathogenesis of COPD

    Andras Rab;Steven M. Rowe;S. Vamsee Raju;Zsuzsa Bebok

  • Primary endothelial cell–specific regulation of hypoxia-inducible factor (HIF)-1 and HIF-2 and their target gene expression profiles during hypoxia

    Rafal Bartoszewski;Adrianna Moszyńska;Marcin Serocki;Aleksandra Cabaj

  • YTRF is the conserved internalization signal of the transferrin receptor, and a second YTRF signal at position 31-34 enhances endocytosis.

    J.F. Collawn;A Lai;D Domingo;M Fitch

  • Role of epithelial sodium channels in the regulation of lung fluid homeostasis

    Sadis Matalon;Rafal Bartoszewski;James F. Collawn

  • The hypoxia-inducible miR-429 regulates hypoxia-inducible factor- 1α expression in human endothelial cells through a negative feedback loop

    Sylwia Bartoszewska;Kinga Kochan;Arkadiusz Piotrowski;Wojciech Kamysz

  • The Unfolded Protein Response (UPR)-activated Transcription Factor X-box-binding Protein 1 (XBP1) Induces MicroRNA-346 Expression That Targets the Human Antigen Peptide Transporter 1 (TAP1) mRNA and Governs Immune Regulatory Genes

    Rafal Bartoszewski;Joseph W. Brewer;Andras Rab;David K. Crossman

Frequent Co-Authors

Sadis Matalon
Sadis Matalon University of Alabama at Birmingham
Ian S. Trowbridge
Ian S. Trowbridge Salk Institute for Biological Studies
Eric J. Sorscher
Eric J. Sorscher Emory University
Carlos M. Ferrario
Carlos M. Ferrario Wake Forest University
Steven M. Rowe
Steven M. Rowe University of Alabama at Birmingham
John A. Tainer
John A. Tainer The University of Texas MD Anderson Cancer Center
John P. Clancy
John P. Clancy Cystic Fibrosis Foundation
Erik M. Schwiebert
Erik M. Schwiebert University of Alabama at Birmingham
Yvonne Paterson
Yvonne Paterson University of Pennsylvania
John C. Kappes
John C. Kappes University of Alabama at Birmingham

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