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Joseph S. Beckman is affiliated with Oregon State University in the United States. Their research spans multiple fields including Medicine, Biochemistry, Genetics and Molecular Biology, and Chemistry. Within these broad categories, Beckman's work touches on important subfields such as Molecular Biology, Neurology, Spectroscopy, Radiology, Nuclear Medicine and Imaging, and Genetics.

Their research focuses on topics including Amyotrophic Lateral Sclerosis Research, Mass Spectrometry Techniques and Applications, Advanced Proteomics Techniques and Applications, Ubiquitin and Proteasome Pathways, Monoclonal and Polyclonal Antibodies Research, Parkinson's Disease Mechanisms and Treatments, and Neurogenetic and Muscular Disorders Research.

Beckman has co-authored multiple papers with frequent collaborators including Blaine R. Roberts, Rachel Franklin, Peter J. Crouch, Ryan A. Mehl, and Jeffrey R. Liddell. These collaborations reflect a network of expertise in both fundamental and applied aspects of mass spectrometry and neurodegenerative disease mechanisms.

Key venues where Beckman has published include bioRxiv (Cold Spring Harbor Laboratory), the Journal of the American Society for Mass Spectrometry, ACS Central Science, Analytical Chemistry, and ACS Chemical Biology. Their publication record includes significant contributions that intersect proteomics, mass spectrometry, and neurobiological applications.

Selected recent papers by Joseph S. Beckman are:

  • Improved Protein and PTM Characterization with a Practical Electron-Based Fragmentation on Q-TOF Instruments, 2021, Journal of the American Society for Mass Spectrometry
  • Comparative Structural Analysis of 20S Proteasome Ortholog Protein Complexes by Native Mass Spectrometry, 2020, ACS Central Science
  • Top-Down Characterization of Denatured Proteins and Native Protein Complexes Using Electron Capture Dissociation Implemented within a Modified Ion Mobility-Mass Spectrometer, 2020, Analytical Chemistry
  • Genetic Incorporation of Two Mutually Orthogonal Bioorthogonal Amino Acids That Enable Efficient Protein Dual-Labeling in Cells, 2021, ACS Chemical Biology
  • Microglial ferroptotic stress causes non-cell autonomous neuronal death, 2024, Molecular Neurodegeneration

Best Publications

  • Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

    Joseph S. Beckman;Tanya W. Beckman;Jun Chen;Patricia A. Marshall

  • Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide.

    R Radi;J S Beckman;K M Bush;B A Freeman

  • Peroxynitrite-induced membrane lipid peroxidation : the cytotoxic potential of superoxide and nitric oxide

    Rafael Radi;Joseph S. Beckman;Kenneth M. Bush;Bruce A. Freeman

  • Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

    Harry Ischiropoulos;Ling Zhu;Jun Chen;Michael Tsai

  • Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

    Mark A. Smith;Peggy L. Richey Harris;Lawrence M. Sayre;Joseph S. Beckman

  • Peroxynitrite formation from macrophage-derived nitric oxide

    Harry Ischiropoulos;Ling Zhu;Joseph S. Beckman

  • Oxidative Damage and Tyrosine Nitration from Peroxynitrite

    Joseph S. Beckman

  • ALS, SOD and peroxynitrite

    Joseph S. Beckman;Michael Carson;Craig D. Smith;Willem H. Koppenol

  • Oxidative stress and nitration in neurodegeneration: cause, effect, or association?

    Harry Ischiropoulos;Joseph S. Beckman

  • Pathological implications of nitric oxide, superoxide and peroxynitrite formation

    Joseph S. Beckman;John P. Crow

  • Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite.

    Joseph S. Beckman;Harry Ischiropoulos;Ling Zhu;Mark van der Woerd

  • Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts

    L. A. MacMillan-Crow;John P. Crow;Jeffrey D. Kerby;Joseph S. Beckman

  • Peroxynitrite-mediated oxidation of dihydrorhodamine 123.

    Neil W. Kooy;James A. Royall;Harry Ischiropoulos;Joseph S. Beckman

  • Selective fluorescent imaging of superoxide in vivo using ethidium-based probes

    Kristine M. Robinson;Michael S. Janes;Mariana Pehar;Jeffrey S. Monette

  • Induction of Nitric Oxide -- Dependent Apoptosis in Motor Neurons by Zinc-Deficient Superoxide Dismutase

    Alvaro G. Estévez;John P. Crow;Jacinda B. Sampson;Christopher Reiter

  • Quantitation of nitrotyrosine levels in lung sections of patients and animals with acute lung injury.

    I. Y. Haddad;G. Pataki;Ping Hu;C. Galliani

  • Polyethylene glycol-conjugated superoxide dismutase and catalase reduce ischemic brain injury

    Tsung H. Liu;Joseph S. Beckman;Bruce A. Freeman;Edward L. Hogan

  • Superoxide Reacts with Nitric Oxide to Nitrate Tyrosine at Physiological pH via Peroxynitrite

    Christopher D. Reiter;Ru-Jeng Teng;Joseph S. Beckman

  • Superoxide Dismutase and Catalase Conjugated to Polyethylene Glycol Increases Endothelial Enzyme Activity and Oxidant Resistance

    J S Beckman;R L Minor;C W White;J E Repine

  • Peroxynitrite-induced luminol chemiluminescence

    R Radi;T P Cosgrove;J S Beckman;B A Freeman

Frequent Co-Authors

Bruce A. Freeman
Bruce A. Freeman University of Pittsburgh
Harry Ischiropoulos
Harry Ischiropoulos Children's Hospital of Philadelphia
Sadis Matalon
Sadis Matalon University of Alabama at Birmingham
Victor M. Darley-Usmar
Victor M. Darley-Usmar University of Alabama at Birmingham
Edward L. Hogan
Edward L. Hogan Medical University of South Carolina
Michael J. Strong
Michael J. Strong University of Michigan–Ann Arbor
Hanjoong Jo
Hanjoong Jo Emory University
Xiao Ming Xu
Xiao Ming Xu Indiana University
Dale E. Bredesen
Dale E. Bredesen University of California, Los Angeles
Mark P. Goldberg
Mark P. Goldberg The University of Texas Southwestern Medical Center

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