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Biology and Biochemistry

D-Index
77
Citations
20406
World Ranking
4796
National Ranking
2317

Overview

Peter J. Mohler is affiliated with The Ohio State University in the United States and has contributed extensively to the fields of medicine, biochemistry, genetics, and molecular biology. Their research primarily focuses on cardiology and cardiovascular medicine, with notable work in cardiac electrophysiology and arrhythmias, cardiac fibrosis and remodeling, and ion channel regulation and function.

Mohler's recent publications cover topics related to COVID-19 and cardiac physiology, reflecting a multidisciplinary approach. Selected recent papers include:

  • Neutralization of the SARS-CoV-2 Omicron BA.4/5 and BA.2.12.1 Subvariants, 2022, New England Journal of Medicine
  • Neutralization of SARS-CoV-2 Omicron sub-lineages BA.1, BA.1.1, and BA.2, 2022, Cell Host & Microbe
  • Neutralization and Stability of SARS-CoV-2 Omicron Variant, 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • MicroRNA Biophysically Modulates Cardiac Action Potential by Direct Binding to Ion Channel, 2021, Circulation
  • Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node, 2020, Nature Communications

Frequent coauthors in Mohler's publications include:

  • Thomas J. Hund
  • Vadim V. Fedorov
  • Xianyao Xu
  • Bryan A. Whitson
  • Anuradha Kalyanasundaram

Common publication venues where Mohler's work appears are:

  • Circulation
  • Heart Rhythm
  • Circulation Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Circulation Arrhythmia and Electrophysiology

Mohler's research spans several specialized subfields:

  • Cardiology and Cardiovascular Medicine
  • Molecular Biology
  • Infectious Diseases
  • Cancer Research
  • Surgery

The main topics of Mohler's scientific work cover:

  • Cardiac electrophysiology and arrhythmias
  • Cardiac Fibrosis and Remodeling
  • Ion channel regulation and function
  • SARS-CoV-2 and COVID-19 Research
  • MicroRNA in disease regulation
  • Cardiac Arrhythmias and Treatments
  • Cardiomyopathy and Myosin Studies

Overall, Mohler's research addresses key mechanisms underlying cardiac function and disease along with emerging infectious threats such as COVID-19, integrating molecular biology techniques with clinical cardiovascular investigations.

Best Publications

  • Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

    Peter J. Mohler;Jean-Jacques Schott;Anthony O. Gramolini;Keith W. Dilly

  • A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation

    Jeffrey R. Erickson;Mei ling A. Joiner;Xiaoqun Guan;William Kutschke

  • FKBP12.6 Deficiency and Defective Calcium Release Channel (Ryanodine Receptor) Function Linked to Exercise-Induced Sudden Cardiac Death

    Xander H T Wehrens;Stephan E. Lehnart;Fannie Huang;John A. Vest

  • Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes

    Peter J. Mohler;Ilaria Rivolta;Carlo Napolitano;Guy LeMaillet

  • CaMKII determines mitochondrial stress responses in heart

    Mei Ling A. Joiner;Olha M. Koval;Jingdong Li;Jingdong Li;B. Julie He

  • A cardiac arrhythmia syndrome caused by loss of ankyrin-B function

    Peter J. Mohler;Igor Splawski;Carlo Napolitano;Georgia Bottelli

  • Atrial fibrillation driven by micro-anatomic intramural re-entry revealed by simultaneous sub-epicardial and sub-endocardial optical mapping in explanted human hearts.

    Brian J. Hansen;Jichao Zhao;Thomas A. Csepe;Brandon T. Moore

  • Inherited Arrhythmias A National Heart, Lung, and Blood Institute and Office of Rare Diseases Workshop Consensus Report About the Diagnosis, Phenotyping, Molecular Mechanisms, and Therapeutic Approaches for Primary Cardiomyopathies of Gene Mutations Affecting Ion Channel Function

    Stephan E. Lehnart;Michael J. Ackerman;D. Woodrow Benson;Ramon Brugada

  • Ankyrin-B Coordinates the Na/K ATPase, Na/Ca Exchanger, and InsP3 Receptor in a Cardiac T-Tubule/SR Microdomain

    Peter J Mohler;Jonathan Q Davis;Vann Bennett

  • A βIV-spectrin/CaMKII signaling complex is essential for membrane excitability in mice

    Thomas J. Hund;Olha M. Koval;Jingdong Li;Patrick J. Wright

  • A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly.

    Mauricio R. Galiano;Smita Jha;Tammy Szu-Yu Ho;Chuansheng Zhang

  • Oxidation of CaMKII determines the cardiotoxic effects of aldosterone

    B. Julie He;Mei Ling A. Joiner;Madhu V. Singh;Elizabeth D. Luczak

  • RETRACTED: L-Type Ca2+ Channel Facilitation Mediated by Phosphorylation of the β Subunit by CaMKII

    Chad E. Grueter;Sunday A. Abiria;Igor Dzhura;Yuejin Wu

  • Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice.

    John A. Jansen;Maartje Noorman;Hassan Musa;Mèra Stein

  • Defining the Cellular Phenotype of “Ankyrin-B Syndrome” Variants Human ANK2 Variants Associated With Clinical Phenotypes Display a Spectrum of Activities in Cardiomyocytes

    Peter J. Mohler;Solena Le Scouarnec;Isabelle Denjoy;John S. Lowe

  • Oxidized CaMKII causes cardiac sinus node dysfunction in mice

    Paari Dominic Swaminathan;Anil Purohit;Siddarth Soni;Niels Voigt;Niels Voigt

  • Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice.

    Jian Shan;Alexander Kushnir;Matthew J. Betzenhauser;Steven Reiken

  • Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency.

    Marina Cerrone;Maartje Noorman;Maartje Noorman;Xianming Lin;Halina Chkourko

  • Yes-Associated Protein 65 Localizes P62c-Yes to the Apical Compartment of Airway Epithelia by Association with Ebp50

    Peter J. Mohler;Silvia M. Kreda;Richard C. Boucher;Marius Sudol

  • Voltage-gated Nav channel targeting in the heart requires an ankyrin-G–dependent cellular pathway

    John S. Lowe;Oleg Palygin;Naina Bhasin;Thomas J. Hund

Frequent Co-Authors

Mark E. Anderson
Mark E. Anderson Johns Hopkins University
Vann Bennett
Vann Bennett Duke University
Matthew N. Rasband
Matthew N. Rasband Baylor College of Medicine
Douglas R. Spitz
Douglas R. Spitz University of Iowa
Xander H.T. Wehrens
Xander H.T. Wehrens Baylor College of Medicine
Silvia G. Priori
Silvia G. Priori University of Pavia
Donald M. Bers
Donald M. Bers University of California, Davis
Robert M. Weiss
Robert M. Weiss University of Iowa
Eric Boerwinkle
Eric Boerwinkle The University of Texas Health Science Center at Houston

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