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Biology and Biochemistry

D-Index
69
Citations
16878
World Ranking
7396
National Ranking
233

Overview

Jian-Dong Jiang is affiliated with Peking Union Medical College Hospital in China. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions in related subfields including Molecular Biology, Pharmacology, Epidemiology, Biomedical Engineering, and Infectious Diseases.

The scientist has published extensively on topics related to alkaloids and their synthesis and pharmacology, gut microbiota and health, as well as disease mechanisms and therapies involving autophagy and ubiquitin-proteasome pathways. Notable subject areas include:

  • Berberine and alkaloids research
  • Alkaloids: synthesis and pharmacology
  • Gut microbiota and health
  • Ginseng Biological Effects and Applications
  • Autophagy in Disease and Therapy
  • Liver Disease Diagnosis and Treatment
  • Ubiquitin and proteasome pathways

Jian-Dong Jiang's recent papers reflect their focus on the interactions between bioactive compounds and microbiota, as well as disease impacts and treatments. Key publications include:

  • Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson's disease by regulating gut microbiota, 2021, published in Signal Transduction and Targeted Therapy
  • Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients, 2021, published in Signal Transduction and Targeted Therapy
  • Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota, 2022, published in Signal Transduction and Targeted Therapy
  • Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome, 2021, published in npj Biofilms and Microbiomes
  • Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota, 2022, published in Acta Pharmaceutica Sinica B

Frequent collaborators in Jian-Dong Jiang's research include:

  • Hang Yu
  • Yanxing Han
  • Yuhuan Li
  • Li-Bin Pan
  • Zhengwei Zhang

The scientist's work has been published in several recurring venues, illustrating their focus and institutional networks within the scientific community. Key publication outlets include:

  • Acta Pharmaceutica Sinica B
  • Frontiers in Pharmacology
  • Engineering
  • Signal Transduction and Targeted Therapy
  • International Journal of Molecular Sciences

Best Publications

  • Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins.

    Weijia Kong;Jing Wei;Parveen Abidi;Meihong Lin

  • Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression

    Hao Zhang;Jing Wei;Rong Xue;Jin-Dan Wu

  • ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent

    Kiranmai Gumireddy;M.V. Ramana Reddy;Stephen C. Cosenza;R. Boomi Nathan

  • Antioxidant and Anti-Inflammatory Activities of Berberine in the Treatment of Diabetes Mellitus

    Zheng Li;Ya-Na Geng;Jian-Dong Jiang;Wei-Jia Kong

  • Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression.

    Wei-Jia Kong;Hao Zhang;Dan-Qing Song;Rong Xue

  • Transforming berberine into its intestine-absorbable form by the gut microbiota.

    Ru Feng;Jia-Wen Shou;Zhen-Xiong Zhao;Chi-Yu He

  • Tissue Distribution of Berberine and Its Metabolites after Oral Administration in Rats

    Xiang-Shan Tan;Jing-Yi Ma;Ru Feng;Chao Ma

  • Extracellular Signal-Regulated Kinase–Dependent Stabilization of Hepatic Low-Density Lipoprotein Receptor mRNA by Herbal Medicine Berberine

    Parveen Abidi;Yue Zhou;Jian-Dong Jiang;Jingwen Liu

  • Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease

    Hong-Mei Yan;Ming-Feng Xia;Yan Wang;Xin-Xia Chang

  • Alkaloids from the Root of Isatis indigotica

    Minghua Chen;Lishe Gan;Sheng Lin;Xiaoliang Wang

  • Arsenic trioxide produces polymerization of microtubules and mitotic arrest before apoptosis in human tumor cell lines.

    Yi He Ling;Jian Dong Jiang;Jian Dong Jiang;James F. Holland;Roman Perez-Soler

  • Combination of simvastatin with berberine improves the lipid-lowering efficacy.

    Wei-Jia Kong;Jin Wei;Zeng-Yan Zuo;Yue-Ming Wang

  • Berberine-induced bioactive metabolites of the gut microbiota improve energy metabolism

    Yan Wang;Jia-Wen Shou;Xiao-Yang Li;Zhen-Xiong Zhao

  • Loss of Epigenetic Control of Synuclein-γ Gene as a Molecular Indicator of Metastasis in a Wide Range of Human Cancers

    Haiyan Liu;Wei Liu;Yinwei Wu;Yue Zhou

  • Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson's disease by regulating gut microbiota.

    Yan Wang;Qian Tong;Shu-Rong Ma;Zhen-Xiong Zhao

  • Chlorogenic acid inhibits glioblastoma growth through repolarizating macrophage from M2 to M1 phenotype

    Nina Xue;Qin Zhou;Ming Ji;Jing Jin

  • Small Molecular Compounds Inhibit HIV-1 Replication through Specifically Stabilizing APOBEC3G *

    Shan Cen;Zong-Gen Peng;Xiao-Yu Li;Xiao-Yu Li;Zhuo-Rong Li

  • Abnormal metabolism of gut microbiota reveals the possible molecular mechanism of nephropathy induced by hyperuricemia.

    Libin Pan;Pei Han;Shurong Ma;Ran Peng

  • Gut Microbiota-Mediated Personalized Treatment of Hyperlipidemia Using Berberine.

    Yan Wang;Qian Tong;Jia-Wen Shou;Zhen-Xiong Zhao

  • STING Agonists Induce an Innate Antiviral Immune Response against Hepatitis B Virus

    Fang Guo;Yanxing Han;Xuesen Zhao;Jianghua Wang

Frequent Co-Authors

Jiangong Shi
Jiangong Shi Peking Union Medical College Hospital
David W. Boykin
David W. Boykin Georgia State University
James F. Holland
James F. Holland Icahn School of Medicine at Mount Sinai
Xue Li
Xue Li Chinese Academy of Agricultural Sciences
Yan Q. Xiong
Yan Q. Xiong University of California, Los Angeles
Hongping He
Hongping He Chinese Academy of Sciences
Yan Li
Yan Li Sun Yat-sen University
Yu Zhang
Yu Zhang Peking University
Jun Liu
Jun Liu Fudan University

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