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Microbiology

D-Index
44
Citations
6873
World Ranking
5153
National Ranking
1976

Overview

Yan Q. Xiong is affiliated with the University of California, Los Angeles, in the United States. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology, with a particular focus on infectious diseases and antimicrobial resistance.

The scientist has published extensively in the fields of infectious diseases, with 26 publications, molecular biology (18 publications), epidemiology (16 publications), plant science (11 publications), and clinical biochemistry (10 publications). Their main research topics include antimicrobial resistance in Staphylococcus, infective endocarditis diagnosis and management, streptococcal infections and treatments, bacterial identification and susceptibility testing, bacteriophages and microbial interactions, bacterial biofilms and quorum sensing, and antibiotic resistance in bacteria.

Yan Q. Xiong's recent papers illustrate a focus on antimicrobial agents and bacterial infections, including:

  • TSPphg Lysin from the Extremophilic Thermus Bacteriophage TSP4 as a Potential Antimicrobial Agent against Both Gram-Negative and Gram-Positive Pathogenic Bacteria (2020, Viruses)
  • Globally deimmunized lysostaphin evades human immune surveillance and enables highly efficacious repeat dosing (2020, Science Advances)
  • The Stringent Response Contributes to Persistent Methicillin-Resistant Staphylococcus aureus Endovascular Infection Through the Purine Biosynthetic Pathway (2020, The Journal of Infectious Diseases)
  • Human DNA methylation signatures differentiate persistent from resolving MRSA bacteremia (2021, Proceedings of the National Academy of Sciences)
  • MMPphg from the thermophilic Meiothermus bacteriophage MMP17 as a potential antimicrobial agent against both Gram-negative and Gram-positive bacteria (2020, Virology Journal)

Their frequent co-authors include Arnold S. Bayer, Michael R. Yeaman, Liang Li, Wessam Abdelhady, and Richard A. Proctor. This network of collaborators contributes to both the depth and breadth of their research output.

Yan Q. Xiong has published multiple articles in prominent scientific journals, with a recurring presence in the following venues:

  • Antimicrobial Agents and Chemotherapy (5 publications)
  • The Journal of Infectious Diseases (4 publications)
  • SSRN Electronic Journal (4 publications)
  • Antibiotics (3 publications)
  • Infection and Immunity (2 publications)

Their work largely concentrates on antimicrobial resistance mechanisms, particularly involving Staphylococcus species, and explores bacterial biofilms, microbial interactions, and novel antibacterial agents derived from bacteriophages. Research efforts also focus on clinical aspects such as diagnosis and management of infective endocarditis and streptococcal infections, as well as molecular and epigenetic factors influencing bacterial persistence and immune evasion.

Best Publications

  • Regulation of virulence determinants in vitro and in vivo in Staphylococcus aureus

    Ambrose L Cheung;Arnold S Bayer;Arnold S Bayer;Gongyi Zhang;Hattie Gresham

  • Failures in Clinical Treatment of Staphylococcus aureus Infection with Daptomycin Are Associated with Alterations in Surface Charge, Membrane Phospholipid Asymmetry, and Drug Binding

    Tiffanny Jones;Michael R. Yeaman;Michael R. Yeaman;Michael R. Yeaman;George Sakoulas;Soo-Jin Yang

  • Advances in antimicrobial peptide immunobiology

    Nannette Y Yount;Arnold S Bayer;Arnold S Bayer;Arnold S Bayer;Yan Q Xiong;Yan Q Xiong;Yan Q Xiong;Michael R Yeaman;Michael R Yeaman;Michael R Yeaman

  • Lack of Wall Teichoic Acids in Staphylococcus aureus Leads to Reduced Interactions with Endothelial Cells and to Attenuated Virulence in a Rabbit Model of Endocarditis

    Christopher Weidenmaier;Andreas Peschel;Yan-Qiong Xiong;Yan-Qiong Xiong;Sascha A. Kristian

  • Regulation of Staphylococcus aureus α-Toxin Gene (hla) Expression by agr, sarA and sae In Vitro and in Experimental Infective Endocarditis

    Yan Q. Xiong;Julie Willard;Michael R. Yeaman;Michael R. Yeaman;Ambrose L. Cheung

  • The Staphylococcus aureus two-component regulatory system, GraRS, senses and confers resistance to selected cationic antimicrobial peptides.

    Soo-Jin Yang;Arnold S. Bayer;Arnold S. Bayer;Nagendra N. Mishra;Michael Meehl

  • Salicylic acid attenuates virulence in endovascular infections by targeting global regulatory pathways in Staphylococcus aureus

    Leon Iri Kupferwasser;Michael R. Yeaman;Cynthia C. Nast;Deborah Kupferwasser

  • Enhanced Expression of dltABCD Is Associated with the Development of Daptomycin Nonsusceptibility in a Clinical Endocarditis Isolate of Staphylococcus aureus

    Soo-Jin Yang;Barry N. Kreiswirth;Barry N. Kreiswirth;George Sakoulas;Michael R. Yeaman;Michael R. Yeaman

  • Daptomycin-Oxacillin Combinations in Treatment of Experimental Endocarditis Caused by Daptomycin-Nonsusceptible Strains of Methicillin-Resistant Staphylococcus aureus with Evolving Oxacillin Susceptibility (the “Seesaw Effect”)

    Soo-Jin Yang;Yan Q. Xiong;Yan Q. Xiong;Susan Boyle-Vavra;Robert Daum

  • Phenotypic and Genotypic Characteristics of Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia In Vitro and in an Experimental Endocarditis Model

    Yan Q Xiong;Vance G Fowler;Michael R Yeaman;Michael R Yeaman;Francoise Perdreau-Remington

  • In Vitro Antibacterial Activities of Platelet Microbicidal Protein and Neutrophil Defensin against Staphylococcus aureus Are Influenced by Antibiotics Differing in Mechanism of Action

    Yan-Qiong Xiong;Michael R. Yeaman;Arnold S. Bayer

  • Real-Time In Vivo Bioluminescent Imaging for Evaluating the Efficacy of Antibiotics in a Rat Staphylococcus aureus Endocarditis Model

    Yan Q. Xiong;Julie Willard;Jagath L. Kadurugamuwa;Jun Yu

  • Role of the serine-rich surface glycoprotein GspB of Streptococcus gordonii in the pathogenesis of infective endocarditis

    Yan Q. Xiong;Barbara A. Bensing;Barbara A. Bensing;Arnold S. Bayer;Henry F. Chambers

  • Regulation of mprF in Daptomycin-Nonsusceptible Staphylococcus aureus Strains

    Soo-Jin Yang;Yan Q. Xiong;Yan Q. Xiong;Yan Q. Xiong;Paul M. Dunman;Jacques Schrenzel

  • Functional Interrelationships between Cell Membrane and Cell Wall in Antimicrobial Peptide-Mediated Killing of Staphylococcus aureus

    Yan Q. Xiong;Yan Q. Xiong;Kasturi Mukhopadhyay;Michael R. Yeaman;Michael R. Yeaman;Jill Adler-Moore

  • A Structural Model for Binding of the Serine-Rich Repeat Adhesin GspB to Host Carbohydrate Receptors

    Tasia M. Pyburn;Barbara A. Bensing;Yan Q. Xiong;Bruce J. Melancon

  • Activation and Transcriptional Interaction between agr RNAII and RNAIII in Staphylococcus aureus In Vitro and in an Experimental Endocarditis Model

    Yan-Qiong Xiong;William Van Wamel;Cynthia C. Nast;Cynthia C. Nast;Michael R. Yeaman

  • Role of mgrA and sarA in methicillin-resistant Staphylococcus aureus autolysis and resistance to cell wall-active antibiotics.

    María Pilar Trotonda;Yan Q Xiong;Yan Q Xiong;Guido Memmi;Arnold S Bayer;Arnold S Bayer

  • Platelet Microbicidal Protein 1: Structural Themes of a Multifunctional Antimicrobial Peptide

    Nannette Y. Yount;Kimberly D. Gank;Yan Qiong Xiong;Arnold S. Bayer

  • In vitro susceptibility of Staphylococcus aureus to thrombin-induced platelet microbicidal protein-1 (tPMP-1) is influenced by cell membrane phospholipid composition and asymmetry.

    Kasturi Mukhopadhyay;William Whitmire;Yan Q. Xiong;Yan Q. Xiong;Jaime Molden

Frequent Co-Authors

Arnold S. Bayer
Arnold S. Bayer University of California, Los Angeles
Michael R. Yeaman
Michael R. Yeaman University of California, Los Angeles
Ambrose L. Cheung
Ambrose L. Cheung Dartmouth College
Barry N. Kreiswirth
Barry N. Kreiswirth Center for Discovery and Innovation
Scott G. Filler
Scott G. Filler University of California, Los Angeles
Henry F. Chambers
Henry F. Chambers University of California, San Francisco
George Sakoulas
George Sakoulas University of California, San Diego
Ashraf S. Ibrahim
Ashraf S. Ibrahim University of California, Los Angeles
Liang Chen
Liang Chen Hackensack Meridian Health Center for Discovery and Innovation
Paul M. Sullam
Paul M. Sullam University of California, San Francisco

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