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Chemistry

D-Index
53
Citations
9552
World Ranking
13119
National Ranking
3459

Overview

Abdu I. Alayash is affiliated with the US Food and Drug Administration in the United States and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. They have focused particularly on topics related to hemoglobin structure and function, heme oxygenase-1 and carbon monoxide, and hemoglobinopathies and related disorders.

Their work spans several subfields including cell biology, molecular biology, genetics, physiology, and pediatrics, perinatology, and child health. Central themes in their research involve erythrocyte function and pathophysiology, neonatal health and biochemistry, iron metabolism and disorders, and thermal regulation in medicine.

Alayash has published multiple papers in notable scientific venues. Some of their recent publications include:

  • "Post-translational modification as a response to cellular stress induced by hemoglobin oxidation in sickle cell disease," 2020, Scientific Reports
  • "Caffeic acid: an antioxidant with novel antisickling properties," 2021, FEBS Open Bio
  • "βCysteine 93 in human hemoglobin: a gateway to oxidative stability in health and disease," 2020, Laboratory Investigation
  • "Mitapivat increases ATP and decreases oxidative stress and erythrocyte mitochondria retention in a SCD mouse model," 2022, Blood Cells Molecules and Diseases
  • "The Impact of COVID-19 Infection on Oxygen Homeostasis: A Molecular Perspective," 2021, Frontiers in Physiology

Frequent co-authors collaborating with Alayash include:

  • Sirsendu Jana
  • Tigist Kassa
  • Michael R. Heaven
  • Richard Prince
  • Yugal Goel

Alayash has published repeatedly in several prominent journals, reflecting areas of sustained scholarly activity and influence. These venues include:

  • Frontiers in Physiology
  • International Journal of Molecular Sciences
  • Scientific Reports
  • Frontiers in Molecular Biosciences
  • Blood

Best Publications

  • Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

    Dominik J. Schaer;Paul W. Buehler;Abdu I. Alayash;John D. Belcher

  • Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

    John D. Belcher;Chunsheng Chen;Julia Nguyen;Liming Milbauer

  • Oxygen therapeutics: can we tame haemoglobin?

    Abdu I Alayash

  • CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin.

    Dominik J. Schaer;Christian A. Schaer;Christian A. Schaer;Paul W. Buehler;Paul W. Buehler;Robert A. Boykins;Robert A. Boykins

  • Redox Reactions of Hemoglobin and Myoglobin: Biological and Toxicological Implications

    Abdu I. Alayash;Rakesh P. Patel;Robert E. Cashon

  • Hemoglobin-based blood substitutes: oxygen carriers, pressor agents, or oxidants?

    Abdu I. Alayash

  • Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification

    Paul W. Buehler;Bindu Abraham;Florence Vallelian;Charlotte Linnemayr

  • Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs

    Felicitas S. Boretti;Paul W. Buehler;Felice D’Agnillo;Katharina Kluge

  • Blood substitutes: why haven’t we been more successful?

    Abdu I. Alayash

  • Structural Basis of Peroxide-mediated Changes in Human Hemoglobin A NOVEL OXIDATIVE PATHWAY

    Yiping Jia;Paul W. Buehler;Robert A. Boykins;Richard M. Venable

  • Determination of extinction coefficients of human hemoglobin in various redox states.

    Fantao Meng;Abdu I. Alayash

  • Site-Specific Cross-Linking of Human and Bovine Hemoglobins Differentially Alters Oxygen Binding and Redox Side Reactions Producing Rhombic Heme and Heme Degradation†

    Enika Nagababu;Somasundaram Ramasamy;Joseph Moses Rifkind;Yiping Jia

  • Toxicities of hemoglobin solutions: in search of in-vitro and in-vivo model systems

    Paul W. Buehler;Abdu I. Alayash

  • Haptoglobin: old protein with new functions.

    Abdu I. Alayash

  • Ascorbate removes key precursors to oxidative damage by cell-free haemoglobin in vitro and in vivo

    Jacqueline Dunne;Alexis Caron;Patrick Menu;Abdu I. Alayash

  • Gating the radical hemoglobin to macrophages: the anti-inflammatory role of CD163, a scavenger receptor.

    Dominik J. Schaer;Abdu I. Alayash;Paul W. Buehler

  • Structural and Functional Characterization of Glutaraldehyde-Polymerized Bovine Hemoglobin and Its Isolated Fractions

    Paul W Buehler;Robert A Boykins;Yiping Jia;Scott Norris

  • Haptoglobin Binding Stabilizes Hemoglobin Ferryl Iron and the Globin Radical on Tyrosine β145

    Christopher E Cooper;Dominik J Schaer;Paul W Buehler;Michael T Wilson

  • Nitric Oxide Binding to Human Ferrihemoglobins Cross-Linked between Either α or β Subunits

    A.I. Alayash;J.C. Fratantoni;C. Bonaventura;J. Bonaventura

  • Hemoglobin and free radicals: implications for the development of a safe blood substitute

    Abdu I. Alayash;Robert E. Cashon

  • Acellular hemoglobin-mediated oxidative stress toward endothelium: a role for ferryl iron

    Daniel W. Goldman;Richard J. Breyer;David Yeh;Beth A. Brockner-Ryan

  • Effects of endogenous ascorbate on oxidation, oxygenation, and toxicokinetics of cell-free modified hemoglobin after exchange transfusion in rat and guinea pig.

    Paul W. Buehler;Felice D'Agnillo;Victoria Hoffman;Abdu I. Alayash

  • Peroxynitrite-Mediated Heme Oxidation and Protein Modification of Native and Chemically Modified Hemoglobins

    Abdu I. Alayash;Beth A.Brockner Ryan;Robert E. Cashon

Frequent Co-Authors

Alvin L. Crumbliss
Alvin L. Crumbliss Duke University
Michael T. Wilson
Michael T. Wilson University of Essex
John S. Olson
John S. Olson Rice University
Celia Bonaventura
Celia Bonaventura Duke University
Chris E. Cooper
Chris E. Cooper University of Essex
Gregory M. Vercellotti
Gregory M. Vercellotti University of Minnesota
Leif Bülow
Leif Bülow Lund University
Bo Åkerström
Bo Åkerström Lund University
Joseph Bonaventura
Joseph Bonaventura Duke University
Swee Lay Thein
Swee Lay Thein King's College London

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