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D-Index & Metrics

Microbiology

D-Index
48
Citations
14602
World Ranking
4629
National Ranking
1785

Overview

I-Cheng Ho is affiliated with Brigham and Women's Hospital in the United States and has contributed extensively to research in the fields of Medicine and Immunology and Microbiology. Their work spans several interrelated subfields including Immunology, Rheumatology, Oncology, Genetics, and Pulmonary and Respiratory Medicine.

Their scholarly output includes numerous papers focusing on immune cell function, cytokine signaling, connective tissue disorders, and related diseases. Central topics in their research include:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Rheumatoid Arthritis Research and Therapies
  • Cytokine Signaling Pathways and Interactions
  • Connective Tissue Disorders Research
  • Cell Adhesion Molecules Research

A selection of recent papers authored or coauthored by I-Cheng Ho includes:

  • "PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis," 2021, published in Matrix Biology
  • "Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts," 2022, published in Scientific Reports
  • "Differential impacts of TNFα inhibitors on the transcriptome of Th cells," 2021, published in Arthritis Research & Therapy
  • "Peptidylarginine deiminase 2 citrullinates MZB1 and promotes the secretion of IgM and IgA," 2023, published in Frontiers in Immunology
  • "Ets1 regulates the differentiation and function of iNKT cells through both Pointed domain-dependent and domain-independent mechanisms," 2020, published in Cellular and Molecular Immunology

Their research has been featured in multiple venues including:

  • Frontiers in Immunology
  • Matrix Biology
  • Scientific Reports
  • Arthritis Research & Therapy
  • Philosophical Transactions of the Royal Society B Biological Sciences

I-Cheng Ho frequently collaborates with several researchers, notably:

  • Bo Sun
  • Konstantin Tsoyi
  • Iván O. Rosas
  • Tzong-Shyuan Tai
  • Wan-Chu Chuang

Best Publications

  • IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells

    Valerie Dardalhon;Amit Awasthi;Hyoung-Joon Kwon;George Galileos

  • The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

    Aurelie T Bauquet;Hulin Jin;Alison M Paterson;Meike Mitsdoerffer

  • The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4

    I-Cheng Ho;Martin R Hodge;John W Rooney;Laurie H Glimcher

  • Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells.

    Caroline Pot;Hulin Jin;Amit Awasthi;Sue Min Liu

  • The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines

    James I Kim;I-Cheng Ho;Michael J Grusby;Laurie H Glimcher

  • GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation.

    I-Cheng Ho;Tzong-Shyuan Tai;Sung-Yun Pai

  • GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells

    Sung-Yun Pai;Morgan L. Truitt;I-Cheng Ho

  • Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity

    Hong-Erh Liang;R Lee Reinhardt;Jennifer K Bando;Brandon M Sullivan

  • HUMAN GATA-3 : A LINEAGE-RESTRICTED TRANSCRIPTION FACTOR THAT REGULATES THE EXPRESSION OF THE T CELL RECEPTOR ALPHA GENE

    I C Ho;P Vorhees;N Marin;B K Oakley

  • GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model

    Hosein Kouros-Mehr;Seth K. Bechis;Euan M. Slorach;Laurie E. Littlepage

  • Critical Roles for Transcription Factor GATA-3 in Thymocyte Development

    Sung-Yun Pai;Morgan L Truitt;Chao-Nan Ting;Jeffrey M Leiden

  • c-maf Promotes T Helper Cell Type 2 (Th2) and Attenuates Th1 Differentiation by Both Interleukin 4–dependent and –independent Mechanisms

    I-Cheng Ho;David Lo;Laurie H. Glimcher

  • The Transcription Factor NFAT4 Is Involved in the Generation and Survival of T Cells

    Mohamed Oukka;I-Cheng Ho;Fabienne Charles de la Brousse;Timothy Hoey

  • Transcription: tantalizing times for T cells.

    I-Cheng Ho;Laurie H Glimcher

  • Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development

    J. I. Kim;Tiansen Li;I.-C. Ho;M. J. Grusby

  • cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1.

    C B Thompson;C Y Wang;I C Ho;P R Bohjanen

  • Ets-1 is a negative regulator of Th17 differentiation

    Jacques Moisan;Roland Grenningloh;Estelle Bettelli;Mohamed Oukka

  • Sequence-specific binding of human Ets-1 to the T cell receptor alpha gene enhancer.

    I-Cheng Ho;Narayan K. Bhat;Lisa R. Gottschalk;Tullia Lindsten

  • Ets-1 is a critical regulator of Ang II-mediated vascular inflammation and remodeling

    Yumei Zhan;Courtney Brown;Elizabeth Maynard;Aleksandra Anshelevich

  • The Cell Type-Specific Expression of the Murine IL-13 Gene Is Regulated by GATA-3

    Hiroko Kishikawa;Jenny Sun;Andrew Choi;Shi-Chuen Miaw

Frequent Co-Authors

Sung-Yun Pai
Sung-Yun Pai National Institutes of Health
Laurie H. Glimcher
Laurie H. Glimcher Harvard University
Jeffrey M. Leiden
Jeffrey M. Leiden Harvard University
Elizabeth W. Karlson
Elizabeth W. Karlson Brigham and Women's Hospital
Mohamed Oukka
Mohamed Oukka University of Washington
Vijay K. Kuchroo
Vijay K. Kuchroo Harvard University
Peter Oettgen
Peter Oettgen Beth Israel Deaconess Medical Center
Michael J. Grusby
Michael J. Grusby Harvard University
Craig B. Thompson
Craig B. Thompson Memorial Sloan Kettering Cancer Center
Arlene H. Sharpe
Arlene H. Sharpe Harvard University

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