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Frank S. Lee

D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
15045
World Ranking
17843
National Ranking
7303

Frank S. Lee publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Frank S. Lee sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 115 publications — 10th percentile

10% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Frank S. Lee D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Frank S. Lee sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 49 D-Index — 9th percentile

9% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Frank S. Lee is affiliated with the University of Pennsylvania in the United States and specializes in biochemistry, genetics, and molecular biology, with a particular focus on cancer research and genetics.

Their research encompasses several subfields, including cancer research, genetics, pulmonary and respiratory medicine, molecular biology, and physiology. The primary topics covered in their work involve high altitude and hypoxia, cancer, hypoxia and metabolism, mitochondrial function and pathology, pulmonary hypertension research and treatments, adipose tissue and metabolism, eicosanoids and hypertension pharmacology, and enzyme production and characterization.

Lee has contributed to numerous publications in notable venues. Frequent publication venues include:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Proceedings of the National Academy of Sciences
  • iScience
  • Trends in Biochemical Sciences
  • Journal of Biological Chemistry

Frequent coauthors collaborating with Lee are:

  • Abigail W. Bigham
  • Daisheng Song
  • Maria C. Rivera
  • Fabiola León-Velarde
  • Melisa Kiyamu

Recent publications authored or coauthored by Lee include:

  • "Tibetan PHD2, an allele with loss-of-function properties" (2020), Proceedings of the National Academy of Sciences
  • "HIF2A gain-of-function mutation modulates the stiffness of smooth muscle cells and compromises vascular mechanics" (2021), iScience
  • "Hypoxia Inducible Factor pathway proteins in high-altitude mammals" (2023), Trends in Biochemical Sciences
  • "High-altitude deer mouse hypoxia-inducible factor-2α shows defective interaction with CREB-binding protein" (2021), Journal of Biological Chemistry
  • "High-Altitude Andean H194R HIF2A Allele Is a Hypomorphic Allele" (2023), Molecular Biology and Evolution

Best Publications

  • Cytokines: Coordinators of Immune and Inflammatory Responses

    Ken-ichi Arai;Frank Lee;Atsushi Miyajima;Shoichiro Miyatake

  • Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer

    Steven E Raper;Narendra Chirmule;Frank S Lee;Nelson A Wivel

  • HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation

    Fang Yu;Sarah B. White;Quan Zhao;Frank S. Lee

  • Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway

    Frank S Lee;Jeremiah Hagler;Zhijian J Chen;Tom Maniatis

  • MEKK1 activates both IκB kinase α and IκB kinase β

    Frank S. Lee;Robert T. Peters;Luan C. Dang;Tom Maniatis

  • Sequence Determinants in Hypoxia-inducible Factor-1α for Hydroxylation by the Prolyl Hydroxylases PHD1, PHD2, and PHD3

    Jianhe Huang;Quan Zhao;Sharon M. Mooney;Frank S. Lee

  • A gain-of-function mutation in the HIF2A gene in familial erythrocytosis

    Melanie J. Percy;Paul W. Furlow;Guy S. Lucas;Xiping Li

  • Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells.

    Frank Lee;Takashi Yokota;Takeshi Otsuka;Lorraine Gemmell

  • Mitogen-activated Protein Kinase/ERK Kinase Kinases 2 and 3 Activate Nuclear Factor-κB through IκB Kinase-α and IκB Kinase-β

    Quan Zhao;Frank S. Lee

  • A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis

    Melanie J. Percy;Quan Zhao;Adrian Flores;Claire Harrison

  • Control of Hemopoiesis by a Bone Marrow Stromal Cell Clone: Lipopolysaccharide- and Interleukin-1--Inducible Production of Colony-Stimulating Factors

    D Rennick;G Yang;L Gemmell;F Lee

  • Human high-altitude adaptation: forward genetics meets the HIF pathway

    Abigail W. Bigham;Frank S. Lee

  • Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

    Kotaro Takeda;Hector L. Aguila;Nehal S. Parikh;Xiping Li

  • Transcription termination at the trp operon attenuators of Escherichia coli and Salmonella typhimurium: RNA secondary structure and regulation of termination.

    Frank Lee;Charles Yanofsky

  • Drug-drug interaction studies of cardiovascular drugs involving P-glycoprotein, an efflux transporter, on the pharmacokinetics of edoxaban, an oral factor Xa inhibitor.

    Jeanne Mendell;Hamim Zahir;Nobuko Matsushima;Robert Noveck

  • Regulation of Dopamine D1 Receptor Function by Physical Interaction with the NMDA Receptors

    Lin Pei;Frank J S Lee;Anna Moszczynska;Brian Vukusic

  • Tight-binding inhibition of angiogenin and ribonuclease A by placental ribonuclease inhibitor.

    Frank S. Lee;Robert Shapiro;Bert L. Vallee

  • Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells

    Choy-Pik Chiu;Courtney Moulds;Robert L. Coffman;Donna Rennick

  • The HIF Pathway and Erythrocytosis

    Frank S. Lee;Melanie J. Percy

  • Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells.

    Takashi Yokota;Naoko Arai;Frank Lee;Donna Rennick

Frequent Co-Authors

Mary Frances McMullin
Mary Frances McMullin Queen's University Belfast
Takashi Yokota
Takashi Yokota Kanazawa University
Donna Rennick
Donna Rennick MSD (United States)
Tim R. Mosmann
Tim R. Mosmann University of Rochester Medical Center
Bert L. Vallee
Bert L. Vallee Harvard University
Ken-ichi Arai
Ken-ichi Arai University of Tokyo
David Oscier
David Oscier Royal Bournemouth Hospital
Naoko Arai
Naoko Arai University of Tokyo
Anthony R. Green
Anthony R. Green University of Cambridge
John A. Smith
John A. Smith University of Alabama at Birmingham

External Links

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Best Scientists Citing Frank S. Lee

Peter J. Ratcliffe

Peter J. Ratcliffe

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Publications: 65

William G. Kaelin

William G. Kaelin

Harvard University

Publications: 62

Ken-ichi Arai

Ken-ichi Arai

University of Tokyo

Publications: 48

Gregg L. Semenza

Gregg L. Semenza

Johns Hopkins University School of Medicine

Publications: 47

Ronald T. Raines

Ronald T. Raines

MIT

Publications: 47

Akseli Hemminki

Akseli Hemminki

University of Helsinki

Publications: 47

Atsushi Miyajima

Atsushi Miyajima

University of Tokyo

Publications: 45

M. Celeste Simon

M. Celeste Simon

University of Pennsylvania

Publications: 37

Karl Deisseroth

Karl Deisseroth

Stanford University

Publications: 35

Roland Lill

Roland Lill

Philipp University of Marburg

Publications: 32

Christopher W. Pugh

Christopher W. Pugh

University of Oxford

Publications: 30

Christopher J. Schofield

Christopher J. Schofield

University of Oxford

Publications: 29

Marcus O. Muench

Marcus O. Muench

University of California, San Francisco

Publications: 24

Fang Liu

Fang Liu

Centre for Addiction and Mental Health

Publications: 22

Nicola Brunetti-Pierri

Nicola Brunetti-Pierri

University of Naples Federico II

Publications: 21

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Sunil K. Manna

Centre for DNA Fingerprinting and Diagnostics

Publications: 21

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