World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
15045
World Ranking
17843
National Ranking
7303

Overview

Frank S. Lee is affiliated with the University of Pennsylvania in the United States and specializes in biochemistry, genetics, and molecular biology, with a particular focus on cancer research and genetics.

Their research encompasses several subfields, including cancer research, genetics, pulmonary and respiratory medicine, molecular biology, and physiology. The primary topics covered in their work involve high altitude and hypoxia, cancer, hypoxia and metabolism, mitochondrial function and pathology, pulmonary hypertension research and treatments, adipose tissue and metabolism, eicosanoids and hypertension pharmacology, and enzyme production and characterization.

Lee has contributed to numerous publications in notable venues. Frequent publication venues include:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Proceedings of the National Academy of Sciences
  • iScience
  • Trends in Biochemical Sciences
  • Journal of Biological Chemistry

Frequent coauthors collaborating with Lee are:

  • Abigail W. Bigham
  • Daisheng Song
  • Maria C. Rivera
  • Fabiola León-Velarde
  • Melisa Kiyamu

Recent publications authored or coauthored by Lee include:

  • "Tibetan PHD2, an allele with loss-of-function properties" (2020), Proceedings of the National Academy of Sciences
  • "HIF2A gain-of-function mutation modulates the stiffness of smooth muscle cells and compromises vascular mechanics" (2021), iScience
  • "Hypoxia Inducible Factor pathway proteins in high-altitude mammals" (2023), Trends in Biochemical Sciences
  • "High-altitude deer mouse hypoxia-inducible factor-2α shows defective interaction with CREB-binding protein" (2021), Journal of Biological Chemistry
  • "High-Altitude Andean H194R HIF2A Allele Is a Hypomorphic Allele" (2023), Molecular Biology and Evolution

Best Publications

  • Cytokines: Coordinators of Immune and Inflammatory Responses

    Ken-ichi Arai;Frank Lee;Atsushi Miyajima;Shoichiro Miyatake

  • Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer

    Steven E Raper;Narendra Chirmule;Frank S Lee;Nelson A Wivel

  • HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation

    Fang Yu;Sarah B. White;Quan Zhao;Frank S. Lee

  • Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway

    Frank S Lee;Jeremiah Hagler;Zhijian J Chen;Tom Maniatis

  • MEKK1 activates both IκB kinase α and IκB kinase β

    Frank S. Lee;Robert T. Peters;Luan C. Dang;Tom Maniatis

  • Sequence Determinants in Hypoxia-inducible Factor-1α for Hydroxylation by the Prolyl Hydroxylases PHD1, PHD2, and PHD3

    Jianhe Huang;Quan Zhao;Sharon M. Mooney;Frank S. Lee

  • A gain-of-function mutation in the HIF2A gene in familial erythrocytosis

    Melanie J. Percy;Paul W. Furlow;Guy S. Lucas;Xiping Li

  • Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells.

    Frank Lee;Takashi Yokota;Takeshi Otsuka;Lorraine Gemmell

  • Mitogen-activated Protein Kinase/ERK Kinase Kinases 2 and 3 Activate Nuclear Factor-κB through IκB Kinase-α and IκB Kinase-β

    Quan Zhao;Frank S. Lee

  • A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis

    Melanie J. Percy;Quan Zhao;Adrian Flores;Claire Harrison

  • Control of Hemopoiesis by a Bone Marrow Stromal Cell Clone: Lipopolysaccharide- and Interleukin-1--Inducible Production of Colony-Stimulating Factors

    D Rennick;G Yang;L Gemmell;F Lee

  • Human high-altitude adaptation: forward genetics meets the HIF pathway

    Abigail W. Bigham;Frank S. Lee

  • Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

    Kotaro Takeda;Hector L. Aguila;Nehal S. Parikh;Xiping Li

  • Transcription termination at the trp operon attenuators of Escherichia coli and Salmonella typhimurium: RNA secondary structure and regulation of termination.

    Frank Lee;Charles Yanofsky

  • Drug-drug interaction studies of cardiovascular drugs involving P-glycoprotein, an efflux transporter, on the pharmacokinetics of edoxaban, an oral factor Xa inhibitor.

    Jeanne Mendell;Hamim Zahir;Nobuko Matsushima;Robert Noveck

  • Regulation of Dopamine D1 Receptor Function by Physical Interaction with the NMDA Receptors

    Lin Pei;Frank J S Lee;Anna Moszczynska;Brian Vukusic

  • Tight-binding inhibition of angiogenin and ribonuclease A by placental ribonuclease inhibitor.

    Frank S. Lee;Robert Shapiro;Bert L. Vallee

  • Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells

    Choy-Pik Chiu;Courtney Moulds;Robert L. Coffman;Donna Rennick

  • The HIF Pathway and Erythrocytosis

    Frank S. Lee;Melanie J. Percy

  • Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells.

    Takashi Yokota;Naoko Arai;Frank Lee;Donna Rennick

Frequent Co-Authors

Mary Frances McMullin
Mary Frances McMullin Queen's University Belfast
Takashi Yokota
Takashi Yokota Kanazawa University
Donna Rennick
Donna Rennick MSD (United States)
Tim R. Mosmann
Tim R. Mosmann University of Rochester Medical Center
Bert L. Vallee
Bert L. Vallee Harvard University
Ken-ichi Arai
Ken-ichi Arai University of Tokyo
David Oscier
David Oscier Royal Bournemouth Hospital
Naoko Arai
Naoko Arai University of Tokyo
Anthony R. Green
Anthony R. Green University of Cambridge
John A. Smith
John A. Smith University of Alabama at Birmingham

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