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Biology and Biochemistry

D-Index
49
Citations
9478
World Ranking
17980
National Ranking
7358

Overview

Marcus O. Muench is affiliated with the University of California, San Francisco, in the United States, with a research focus primarily in Medicine and Immunology and Microbiology.

The scientist's research spans several subfields, notably Hematology, Immunology, Infectious Diseases, Epidemiology, and Biochemistry. Key topics addressed in their work include Blood groups and transfusion, Blood transfusion and management, Hematopoietic Stem Cell Transplantation, Immune Cell Function and Interaction, SARS-CoV-2 and COVID-19 Research, Platelet Disorders and Treatments, and Liver Disease Diagnosis and Treatment.

Their frequent collaboration network includes researchers such as Rachael P. Jackman, Renata Gilfanova, Johnson Q. Tran, Alan G. Gutierrez, and Alvin Hui, indicating a broad engagement in joint scientific investigations.

Frequent publication venues where their work appears include:

  • Transfusion
  • Frontiers in Immunology
  • Frontiers in Hematology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Biotechnology

Representative recent papers authored or coauthored by Marcus O. Muench include:

  • Blood donor obesity is associated with changes in red blood cell metabolism and susceptibility to hemolysis in cold storage and in response to osmotic and oxidative stress, 2020, Transfusion
  • Generation of recombinant hyperimmune globulins from diverse B-cell repertoires, 2021, Nature Biotechnology
  • Frequent detection but lack of infectivity of SARS-CoV-2 RNA in presymptomatic, infected blood donor plasma, 2022, Journal of Clinical Investigation
  • Immunodeficient mice are better for modeling the transfusion of human blood components than wild-type mice, 2020, PLoS ONE
  • A bioinspired and chemically defined alternative to dimethyl sulfoxide for the cryopreservation of human hematopoietic stem cells, 2021, Bone Marrow Transplantation

Best Publications

  • Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero

    Jeff E. Mold;Jakob Michaëlsson;Trevor D. Burt;Marcus O. Muench

  • Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs

    C. Hannum;J. Culpepper;D. Campbell;T. McClanahan

  • Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac

    Fei Xie;Lin Ye;Judy C. Chang;Ashley I. Beyer

  • Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63

    Ilona Glowacka;Stephanie Bertram;Petra Herzog;Susanne Pfefferle

  • Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection

    Lin Ye;Jiaming Wang;Ashley I. Beyer;Fernando Teque

  • Identification of a common T/natural killer cell progenitor in human fetal thymus.

    María José Sánchez;Marcus O. Muench;Maria Grazia Roncarolo;Lewis L. Lanier

  • Whole-genome fingerprint of the DNA methylome during human B cell differentiation

    Marta Kulis;Angelika Merkel;Simon Heath;Ana C Queirós

  • Exosomes from red blood cell units bind to monocytes and induce proinflammatory cytokines, boosting T-cell responses in vitro

    Ali Danesh;Heather C. Inglis;Rachael P. Jackman;Shiquan Wu

  • Bone marrow transplantation with interleukin-1 plus kit-ligand ex vivo expanded bone marrow accelerates hematopoietic reconstitution in mice without the loss of stem cell lineage and proliferative potential

    Marcus O. Muench;Meri T. Firpo;Malcolm A.S. Moore

  • Genome editing using CRISPR-Cas9 to create the HPFH genotype in HSPCs: An approach for treating sickle cell disease and β-thalassemia

    Lin Ye;Jiaming Wang;Yuting Tan;Ashley I. Beyer

  • Expression of CD33, CD38, and HLA-DR on CD34+ human fetal liver progenitors with a high proliferative potential.

    Marcus O. Muench;James Cupp;Josephine Polakoff;Maria Grazia Roncarolo

  • Interactions among colony-stimulating factors, IL-1 beta, IL-6, and kit-ligand in the regulation of primitive murine hematopoietic cells.

    M. O. Muench;J. G. Schneider;M. A. S. Moore

  • A Neutralizing Monoclonal Antibody Targeting the Acid-Sensitive Region in Chikungunya Virus E2 Protects from Disease

    Suganya Selvarajah;Suganya Selvarajah;Nicole R. Sexton;Kristen M. Kahle;Rachel H. Fong

  • FLK-2/FLT-3 ligand regulates the growth of early myeloid progenitors isolated from human fetal liver.

    Marcus O. Muench;Maria Grazia Roncarolo;Satish Menon;Yuming Xu

  • Phenotypic and functional analysis of T-cell precursors in the human fetal liver and thymus: CD7 expression in the early stages of T- and myeloid-cell development

    Alicia Bárcena;Marcus O. Muench;Anne H.M. Galy;James Cupp

  • The FLK2/FLT3 ligand synergizes with interleukin-7 in promoting stromal- cell-independent expansion and differentiation of human fetal pro-B cells in vitro

    R Namikawa;MO Muench;JE de Vries;MG Roncarolo

  • A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network.

    Seung-Tae Lee;Yuanyuan Xiao;Marcus O. Muench;Jianqiao Xiao

  • Purification and Partial Characterization of a Human Hematopoietic Precursor Population

    Clay Smith;Cristina Gasparetto;Nancy Collins;Alfred Gillio

  • Searching for common stem cells of the hepatic and hematopoietic systems in the human fetal liver: CD34+ cytokeratin 7/8+ cells express markers for stellate cells

    David L Suskind;Marcus O Muench

  • Expression of Fas/CD95 and Bcl-2 by primitive hematopoietic progenitors freshly isolated from human fetal liver

    Alicia Bárcena;Suk W. Park;Babak Banapour;Marcus O. Muench

Frequent Co-Authors

Maria Grazia Roncarolo
Maria Grazia Roncarolo Stanford University
Philip J. Norris
Philip J. Norris University of California, San Francisco
Malcolm A.S. Moore
Malcolm A.S. Moore Memorial Sloan Kettering Cancer Center
Joseph L. Wiemels
Joseph L. Wiemels University of Southern California
Yuet Wai Kan
Yuet Wai Kan University of California, San Francisco
Susan J. Fisher
Susan J. Fisher University of California, San Francisco
Sheila M. Keating
Sheila M. Keating University of California, San Francisco
Michael R. Harrison
Michael R. Harrison Duke University
José I. Martín-Subero
José I. Martín-Subero University of Barcelona
Simon Heath
Simon Heath Pompeu Fabra University

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