Kazuo Nagasawa mostly deals with Organic chemistry, Stereochemistry, Guanidine, Total synthesis and Thiourea. His study in Nitroaldol reaction, Bifunctional and Stereoselectivity is done as part of Organic chemistry. His Stereochemistry study integrates concerns from other disciplines, such as G-quadruplex, Biological activity, Biochemistry and Cycloaddition.
His Guanidine study deals with Enantioselective synthesis intersecting with Phase-transfer catalyst, Nitro and Diamine. The study incorporates disciplines such as Sodium channel, Overman rearrangement, Inorganic chemistry, Aminal and Sigmatropic reaction in addition to Total synthesis. His Thiourea research is multidisciplinary, relying on both Organocatalysis, Medicinal chemistry and Catalysis, Baylis–Hillman reaction.
His primary scientific interests are in Stereochemistry, Organic chemistry, Guanidine, Catalysis and G-quadruplex. His work on Total synthesis as part of general Stereochemistry research is frequently linked to Side chain, bridging the gap between disciplines. His study in Enantioselective synthesis, Organocatalysis and Yield are all subfields of Organic chemistry.
In his research on the topic of Guanidine, Thiourea, Nitroaldol reaction and Tetralone is strongly related with Bifunctional. He interconnects Combinatorial chemistry and Medicinal chemistry in the investigation of issues within Catalysis. The G-quadruplex study combines topics in areas such as Telomere, Biophysics and Ligand.
His primary areas of investigation include G-quadruplex, Stereochemistry, Telomestatin, DNA and Enantioselective synthesis. His study in G-quadruplex is interdisciplinary in nature, drawing from both Biophysics, Nucleic acid, Computational biology and Binding site. His Stereochemistry study frequently links to other fields, such as Regioselectivity.
Kazuo Nagasawa combines subjects such as Molecule, Stacking and Helicase with his study of Telomestatin. Kazuo Nagasawa has researched Enantioselective synthesis in several fields, including Bifunctional and Guanidine. His study with Catalysis involves better knowledge in Organic chemistry.
His main research concerns G-quadruplex, Telomestatin, Stereochemistry, Computational biology and Biophysics. Kazuo Nagasawa has included themes like Transcription, E2F1, Mutant, Coding region and Genomic imprinting in his G-quadruplex study. The various areas that he examines in his Telomestatin study include Stacking, DNA damage, Binding site and A-DNA.
His research in Stereochemistry intersects with topics in Regioselectivity and Enantioselective synthesis. His work deals with themes such as Intramolecular force, Isomerization and Coupling reaction, which intersect with Enantioselective synthesis. His Total synthesis research incorporates themes from Bifunctional, Kinetic resolution and Tetralones.
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Development of bis-thiourea-type organocatalyst for asymmetric Baylis–Hillman reaction
Yoshihiro Sohtome;Aya Tanatani;Yuichi Hashimoto;Kazuo Nagasawa.
Tetrahedron Letters (2004)
Guanidine-Thiourea Bifunctional Organocatalyst for the Asymmetric Henry (Nitroaldol) Reaction
Yoshihiro Sohtome;Yuichi Hashimoto;Kazuo Nagasawa.
Advanced Synthesis & Catalysis (2005)
Total Synthesis of Pinnatoxin A
John A. McCauley;Kazuo Nagasawa;Peter A. Lander;Steven G. Mischke.
Journal of the American Chemical Society (1998)
Diastereoselective and Enantioselective Henry (Nitroaldol) Reaction Utilizing a Guanidine-Thiourea Bifunctional Organocatalyst
Yoshihiro Sohtome;Yuichi Hashimoto;Kazuo Nagasawa.
European Journal of Organic Chemistry (2006)
C2‐Symmetric Chiral Pentacyclic Guanidine: A Phase‐Transfer Catalyst for the Asymmetric Alkylation of tert‐Butyl Glycinate Schiff Base
Tetsuya Kita;Angelina Georgieva;Yuichi Hashimoto;Tadashi Nakata.
Angewandte Chemie (2002)
Entropy‐Controlled Catalytic Asymmetric 1,4‐Type Friedel–Crafts Reaction of Phenols Using Conformationally Flexible Guanidine/Bisthiourea Organocatalyst
Yoshihiro Sohtome;Bongki Shin;Natsuko Horitsugi;Rika Takagi.
Angewandte Chemie (2010)
Organocatalytic Asymmetric Nitroaldol Reaction: Cooperative Effects of Guanidine and Thiourea Functional Groups
Yoshihiro Sohtome;Nobuko Takemura;Keisuke Takada;Rika Takagi.
Chemistry-an Asian Journal (2007)
Solution Structure of an Intramolecular (3 + 1) Human Telomeric G-Quadruplex Bound to a Telomestatin Derivative
Wan Jun Chung;Brahim Heddi;Masayuki Tera;Keisuke Iida.
Journal of the American Chemical Society (2013)
Solvent-dependent enantiodivergent Mannich-type reaction: utilizing a conformationally flexible guanidine/bisthiourea organocatalyst.
Yoshihiro Sohtome;Shinji Tanaka;Keisuke Takada;Takahisa Yamaguchi.
Angewandte Chemie (2010)
Rif1 binds to G quadruplexes and suppresses replication over long distances
Yutaka Kanoh;Seiji Matsumoto;Rino Fukatsu;Naoko Kakusho.
Nature Structural & Molecular Biology (2015)
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