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Chemistry

D-Index
52
Citations
9376
World Ranking
13540
National Ranking
1035

Overview

Kazuo Nagasawa is a researcher affiliated with Tokyo University of Agriculture and Technology in Japan. Their work spans multiple interconnected fields, primarily focusing on biochemistry, genetics, molecular biology, and chemistry. Their research portfolio includes a significant number of publications contributing to these scientific domains.

They have published extensively within subfields such as molecular biology, organic chemistry, pathology and forensic medicine, pharmacology, and environmental chemistry.

Their main research topics include:

  • DNA and Nucleic Acid Chemistry
  • Advanced biosensing and bioanalysis techniques
  • RNA Interference and Gene Delivery
  • Vitamin D Research Studies
  • Chemical synthesis and alkaloids
  • Marine Toxins and Detection Methods
  • Alkaloids: synthesis and pharmacology

Their publication record shows frequent contributions to the following venues:

  • The Journal of Organic Chemistry (6 publications)
  • Chemical Communications (5 publications)
  • The Cambridge Structural Database (4 publications)
  • Biochemical and Biophysical Research Communications (2 publications)
  • Journal of the American Chemical Society (2 publications)

They have often collaborated with several authors, including:

  • Minami Odagi (29 joint works)
  • Ryota Sakamoto (13 joint works)
  • Masayuki Tera (13 joint works)
  • Yue Ma (12 joint works)
  • Keisuke Hosoya (9 joint works)

Among the recent papers authored or co-authored by Kazuo Nagasawa are:

  • Topologies of G-quadruplex: Biological functions and regulation by ligands, 2020, Biochemical and Biophysical Research Communications
  • Differential diagnosis of vitamin D-related hypercalcemia using serum vitamin D metabolite profiling, 2020, Journal of Bone and Mineral Research
  • Discovery of a Vitamin D Receptor-Silent Vitamin D Derivative That Impairs Sterol Regulatory Element-Binding Protein In Vivo, 2021, Journal of Medicinal Chemistry
  • Enantioselective Total Synthesis of (+)-Stephadiamine through Bioinspired Aza-Benzilic Acid Type Rearrangement, 2021, Journal of the American Chemical Society
  • Target identification of a macrocyclic hexaoxazole G-quadruplex ligand using post-target-binding visualization, 2020, Chemical Communications

Best Publications

  • Development of bis-thiourea-type organocatalyst for asymmetric Baylis–Hillman reaction

    Yoshihiro Sohtome;Aya Tanatani;Yuichi Hashimoto;Kazuo Nagasawa

  • Guanidine-Thiourea Bifunctional Organocatalyst for the Asymmetric Henry (Nitroaldol) Reaction

    Yoshihiro Sohtome;Yuichi Hashimoto;Kazuo Nagasawa

  • Total Synthesis of Pinnatoxin A

    John A. McCauley;Kazuo Nagasawa;Peter A. Lander;Steven G. Mischke

  • C2‐Symmetric Chiral Pentacyclic Guanidine: A Phase‐Transfer Catalyst for the Asymmetric Alkylation of tert‐Butyl Glycinate Schiff Base

    Tetsuya Kita;Angelina Georgieva;Yuichi Hashimoto;Tadashi Nakata

  • Diastereoselective and Enantioselective Henry (Nitroaldol) Reaction Utilizing a Guanidine-Thiourea Bifunctional Organocatalyst

    Yoshihiro Sohtome;Yuichi Hashimoto;Kazuo Nagasawa

  • Rif1 binds to G quadruplexes and suppresses replication over long distances

    Yutaka Kanoh;Seiji Matsumoto;Rino Fukatsu;Naoko Kakusho

  • Solution Structure of an Intramolecular (3 + 1) Human Telomeric G-Quadruplex Bound to a Telomestatin Derivative

    Wan Jun Chung;Brahim Heddi;Masayuki Tera;Keisuke Iida

  • Entropy‐Controlled Catalytic Asymmetric 1,4‐Type Friedel–Crafts Reaction of Phenols Using Conformationally Flexible Guanidine/Bisthiourea Organocatalyst

    Yoshihiro Sohtome;Bongki Shin;Natsuko Horitsugi;Rika Takagi

  • Solvent-dependent enantiodivergent Mannich-type reaction: utilizing a conformationally flexible guanidine/bisthiourea organocatalyst.

    Yoshihiro Sohtome;Shinji Tanaka;Keisuke Takada;Takahisa Yamaguchi

  • A nonclassical vitamin D receptor pathway suppresses renal fibrosis

    Ichiaki Ito;Tsuyoshi Waku;Masato Aoki;Rumi Abe

  • Organocatalytic Asymmetric Nitroaldol Reaction: Cooperative Effects of Guanidine and Thiourea Functional Groups

    Yoshihiro Sohtome;Nobuko Takemura;Keisuke Takada;Rika Takagi

  • Macrocyclic hexaoxazoles as sequence- and mode-selective G-quadruplex binders.

    Masayuki Tera;Hiromichi Ishizuka;Motoki Takagi;Masami Suganuma

  • Novel non-steroidal/non-anilide type androgen antagonists with an isoxazolone moiety.

    Toshiyasu Ishioka;Asako Kubo;Yukiko Koiso;Kazuo Nagasawa

  • A Novel Glucosylation Reaction on Anthocyanins Catalyzed by Acyl-Glucose–Dependent Glucosyltransferase in the Petals of Carnation and Delphinium

    Yuki Matsuba;Nobuhiro Sasaki;Masayuki Tera;Masachika Okamura

  • Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP

    Lisa Asano;Mizuki Watanabe;Yuta Ryoden;Kousuke Usuda

  • Anti-androgens with full antagonistic activity toward human prostate tumor LNCaP cells with mutated androgen receptor

    Toshiyasu Ishioka;Aya Tanatani;Kazuo Nagasawa;Yuichi Hashimoto

  • Ligand-induced conformational changes with cation ejection upon binding to human telomeric DNA G-quadruplexes.

    Adrien Marchand;Anton Granzhan;Keisuke Iida;Yamato Tsushima

  • Topologies of G-quadruplex: Biological functions and regulation by ligands

    Yue Ma;Keisuke Iida;Kazuo Nagasawa

  • Origin of Stereocontrol in Guanidine-Bisurea Bifunctional Organocatalyst That Promotes α-Hydroxylation of Tetralone-Derived β-Ketoesters: Asymmetric Synthesis of β- and γ-Substituted Tetralone Derivatives via Organocatalytic Oxidative Kinetic Resolution

    Minami Odagi;Kota Furukori;Yoshiharu Yamamoto;Makoto Sato

  • Dynamic asymmetric organocatalysis: cooperative effects of weak interactions and conformational flexibility in asymmetric organocatalysts

    Yoshihiro Sohtome;Kazuo Nagasawa

  • Thalidomide and its analogues as cyclooxygenase inhibitors.

    Tomomi Noguchi;Rumiko Shimazawa;Kazuo Nagasawa;Yuichi Hashimoto

Frequent Co-Authors

Yuichi Hashimoto
Yuichi Hashimoto University of Tokyo
Kazuo Shin-ya
Kazuo Shin-ya National Institute of Advanced Industrial Science and Technology
Kazunori Ikebukuro
Kazunori Ikebukuro Tokyo University of Agriculture and Technology
Hiroyuki Koshino
Hiroyuki Koshino Tokyo University of Agriculture
Keiichi Noguchi
Keiichi Noguchi Tokyo University of Agriculture and Technology
Hisao Masai
Hisao Masai Tokyo Metropolitan Institute of Medical Science
Koji Sode
Koji Sode University of North Carolina at Chapel Hill
Yasukatsu Oshima
Yasukatsu Oshima Tohoku University
Kazuhiko Nakabayashi
Kazuhiko Nakabayashi National Center For Child Health and Development

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