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D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
12863
World Ranking
9798
National Ranking
750

Overview

Chris M. Grant is affiliated with the University of Manchester in the United Kingdom. Their research spans the fields of biochemistry, genetics, and molecular biology, with notable contributions also in medicine. Within these broad domains, their work focuses primarily on molecular biology, oncology, cell biology, genetics, and the history and philosophy of science.

The principal topics covered by their research include RNA and protein synthesis mechanisms, RNA research and splicing, RNA modifications and cancer, fungal and yeast genetics research, endoplasmic reticulum stress and disease, prion diseases and protein misfolding, and lymphoma diagnosis and treatment.

Grant has contributed to several recent papers, including:

  • Early evidence for historical overfishing in the Gulf of Mexico, 2021, published in Science Advances
  • Integrated multi-omics reveals common properties underlying stress granule and P-body formation, 2021, published in RNA Biology
  • Yeast Protein Kinase A Isoforms: A Means of Encoding Specificity in the Response to Diverse Stress Conditions?, 2022, published in Biomolecules
  • Tolerance to nascent protein misfolding stress requires fine-tuning of the cAMP/PKA pathway, 2021, published in Journal of Biological Chemistry
  • Interaction of the La-related protein Slf1 with colliding ribosomes maintains translation of oxidative-stress responsive mRNAs, 2023, published in Nucleic Acids Research

Their research has been featured frequently in specific scientific venues, with multiple publications appearing in Blood, Journal of Biological Chemistry, Nucleic Acids Research, bioRxiv (Cold Spring Harbor Laboratory), and Journal of Community Hospital Internal Medicine Perspectives.

Collaboration is evident in their co-authorship record, working repeatedly with colleagues such as Simon J. Hubbard, Christopher J. Kershaw, Mark Ashe, Declan R. Creamer, and Michael G. Nelson.

Best Publications

  • The Response to Heat Shock and Oxidative Stress in Saccharomyces cerevisiae

    Kevin A. Morano;Chris M. Grant;W. Scott Moye-Rowley

  • Role of the glutathione/glutaredoxin and thioredoxin systems in yeast growth and response to stress conditions.

    Chris M. Grant

  • Global Translational Responses to Oxidative Stress Impact upon Multiple Levels of Protein Synthesis

    Daniel Shenton;Julia B. Smirnova;Julian N. Selley;Kathleen Carroll

  • Glutathione is an essential metabolite required for resistance to oxidative stress in the yeast Saccharomyces cerevisiae.

    Chris M. Grant;Fiona H. MacIver;Ian W. Dawes

  • Protein S-thiolation targets glycolysis and protein synthesis in response to oxidative stress in the yeast Saccharomyces cerevisiae

    Daniel Shenton;Chris M. Grant

  • The yeast Saccharomyces cerevisiae contains two glutaredoxin genes that are required for protection against reactive oxygen species.

    Sandra Luikenhuis;Gabriel Perrone;Ian W. Dawes;Chris M. Grant

  • Yeast glutathione reductase is required for protection against oxidative stress and is a target gene for yAP-1 transcriptional regulation

    Chris M. Grant;Lindsay P. Collinson;Jung Hye Roe;Ian W. Dawes

  • Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast Saccharomyces cerevisiae due to an accumulation of the dipeptide gamma-glutamylcysteine.

    C M Grant;F H MacIver;I W Dawes

  • Glutathione and catalase provide overlapping defenses for protection against hydrogen peroxide in the yeast Saccharomyces cerevisiae

    Chris M. Grant;Gabriel Perrone;Ian W. Dawes

  • Redox control of exofacial protein thiols/disulfides by protein disulfide isomerase.

    Xing-Mai Jiang;Melinda Fitzgerald;Chris M. Grant;Philip J. Hogg

  • Metabolic reconfiguration is a regulated response to oxidative stress

    Chris M Grant

  • Guidelines and recommendations on yeast cell death nomenclature

    Didac Carmona-Gutierrez;Maria Anna Bauer;Andreas Zimmermann;Andrés Aguilera

  • Differential Protein S-Thiolation of Glyceraldehyde-3-Phosphate Dehydrogenase Isoenzymes Influences Sensitivity to Oxidative Stress

    Chris M. Grant;Kathryn A. Quinn;Ian W. Dawes

  • Mitochondrial function is required for resistance to oxidative stress in the yeast Saccharomyces cerevisiae.

    Chris M Grant;Fiona H MacIver;Ian W Dawes

  • The Yeast Glutaredoxins Are Active as Glutathione Peroxidases

    Emma J. Collinson;Glen L. Wheeler;Ester Ocón Garrido;Angela M. Avery

  • The Thioredoxin System Protects Ribosomes against Stress-induced Aggregation

    Jonathan D. Rand;Chris M. Grant

  • Thioredoxins are required for protection against a reductive stress in the yeast Saccharomyces cerevisiae

    Eleanor W. Trotter;Chris M. Grant

  • The freeze-thaw stress response of the yeast Saccharomyces cerevisiae is growth phase specific and is controlled by nutritional state via the RAS-cyclic AMP signal transduction pathway.

    Jong In Park;Chris M. Grant;Paul V. Attfield;Ian W. Dawes

  • Role of Yeast Glutaredoxins as Glutathione S-transferases

    Emma J. Collinson;Chris M. Grant

  • Non-reciprocal regulation of the redox state of the glutathione–glutaredoxin and thioredoxin systems

    Eleanor W Trotter;Chris M Grant

Frequent Co-Authors

Ian W. Dawes
Ian W. Dawes University of New South Wales
Simon J. Hubbard
Simon J. Hubbard Manchester Academic Health Science Centre
Mick F. Tuite
Mick F. Tuite University of Kent
Graham D. Pavitt
Graham D. Pavitt University of Manchester
Paul F. G. Sims
Paul F. G. Sims University of Manchester
Robert J. Beynon
Robert J. Beynon University of Liverpool
Markus Ralser
Markus Ralser Charité - University Medicine Berlin
Jens Nielsen
Jens Nielsen Chalmers University of Technology
John E. G. McCarthy
John E. G. McCarthy University of Warwick
Lorenzo Galluzzi
Lorenzo Galluzzi Cornell University

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