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Biology and Biochemistry

D-Index
48
Citations
7141
World Ranking
18472
National Ranking
1445

Overview

Paul F. G. Sims is affiliated with the University of Manchester in the United Kingdom. Their research focuses primarily on the fields of Medicine and Immunology and Microbiology, with a concentration on several subfields, including Epidemiology, Health, Immunology, Infectious Diseases, and Microbiology.

The scientist's work covers key topics such as Cervical Cancer and HPV Research, Vaccine Coverage and Hesitancy, Immune Response and Inflammation, Antimicrobial Resistance in Staphylococcus, and Antimicrobial Peptides and Activities.

Paul F. G. Sims has contributed to the body of scientific knowledge through multiple publications, including recent papers such as:

  • Feasibility of HPV self-sampling pathway in Kathmandu Valley, Nepal using a human-centred design approach, 2021, Sexual and Reproductive Health Matters
  • CD209d/e are required for macrophage-mediated phagocytosis and activation during methicillin-resistant Staphylococcus aureus pulmonary host defense, 2025, The Journal of Immunology

Their frequent coauthors include Swastika Shrestha, Saki Thapa, Andreea Ardelean, Anamika Basu, and Maxine Caws.

The prominent venues for their publications include:

  • Sexual and Reproductive Health Matters
  • The Journal of Immunology

Paul F. G. Sims's scientific contributions are situated within a framework that bridges clinical and immunological research, addressing both population-level health concerns and molecular immune mechanisms. The topics researched demonstrate an intersection between epidemiology of infectious diseases and cellular immune response, particularly with a focus on antimicrobial resistance.

Best Publications

  • Sequence Variation of the Hydroxymethyldihydropterin Pyrophosphokinase: Dihydropteroate Synthase Gene in Lines of the Human Malaria Parasite, Plasmodium falciparum, with Differing Resistance to Sulfadoxine

    Darren R. Brooks;Ping Wang;Martin Read;William M. Watkins

  • Pyrimethamine–sulfadoxine resistance in Plasmodium falciparum: what next?

    Carol Hopkins Sibley;John E Hyde;Paul F.G Sims;Christopher V Plowe

  • Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization.

    Ping Wang;Martin Read;Paul F. G. Sims;John E. Hyde

  • Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine-resistant malaria

    Tony Triglia;Ping Wang;Paul F.G. Sims;John E. Hyde

  • Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins.

    Ping Wang;Chung Shinn Lee;Riad Bayoumi;Abdoulaye Djimde

  • Prevalence of Toxoplasma gondii in commercial meat products as monitored by polymerase chain reaction--food for thought?

    Tanya V. Aspinall;Damian Marlee;John E. Hyde;Paul F.G. Sims

  • Quantitative proteomics of the human malaria parasite Plasmodium falciparum and its application to studies of development and inhibition

    Niroshini Nirmalan;Paul F. G. Sims;John E. Hyde

  • The Molecular Basis of Sulfonamide Resistance in Toxoplasma gondii and Implications for the Clinical Management of Toxoplasmosis

    Tanya V. Aspinall;David H. M. Joynson;Edward Guy;John E. Hyde

  • Characterisation of the dihydrofolate reductase-thymidylate synthetase gene from human malaria parasites highly resistant to pyrimethamine.

    Valerie A. Snewin;Susan M. England;Paul F.G. Sims;John E. Hyde

  • The identification, molecular cloning and characterisation of a gene from Phanerochaete chrysosporium that shows strong homology to the exo-cellobiohydrolase I gene from Trichoderma reesei.

    Paul Sims;Carolyn James;Paul Broda

  • Comparative folate metabolism in humans and malaria parasites (part I): pointers for malaria treatment from cancer chemotherapy.

    Alexis Nzila;Steve A. Ward;Kevin Marsh;Kevin Marsh;Paul F.G. Sims

  • Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up-regulated

    Lydia M. Castelli;Jennifer Lui;Susan G. Campbell;Susan G. Campbell;William Rowe

  • Molecular evidence for multiple Toxoplasma gondii infections in individual patients in England and Wales: Public health implications

    Tanya V. Aspinall;Edward C. Guy;Katherine E. Roberts;David H.M. Joynson

  • Global absolute quantification of a proteome: Challenges in the deployment of a QconCAT strategy.

    Philip Brownridge;Stephen W. Holman;Simon J. Gaskell;Christopher M. Grant

  • Utilization of exogenous folate in the human malaria parasite Plasmodium falciparum and its critical role in antifolate drug synergy.

    Ping Wang;Reynolds K. B. Brobey;Toshihiro Horii;Paul F. G. Sims

  • Lamin B1 maintains the functional plasticity of nucleoli

    Catherine Martin;Songbi Chen;Apolinar Maya-Mendoza;Josip Lovric

  • A MUTATION-SPECIFIC PCR SYSTEM TO DETECT SEQUENCE VARIATION IN THE DIHYDROPTEROATE SYNTHETASE GENE OF PLASMODIUM FALCIPARUM

    Ping Wang;Darren R. Brooks;Paul F.G. Sims;John E. Hyde

  • Global mRNA selection mechanisms for translation initiation

    Joseph Costello;Lydia M Castelli;William Rowe;Christopher J Kershaw

  • Direct and Absolute Quantification of over 1800 Yeast Proteins via Selected Reaction Monitoring

    Craig Lawless;Stephen W. Holman;Philip Brownridge;Karin Lanthaler

  • Characterisation of the gene encoding an unusually divergent TATA-Binding Protein (TBP) from the extremely A+T-rich human malaria parasite Plasmodium falciparum

    Michael B. McAndrew;Martin Read;Paul F.G. Sims;John E. Hyde

Frequent Co-Authors

John E. Hyde
John E. Hyde University of Manchester
Simon J. Hubbard
Simon J. Hubbard Manchester Academic Health Science Centre
Paul R. J. Birch
Paul R. J. Birch James Hutton Institute
Chris M. Grant
Chris M. Grant University of Manchester
Graham D. Pavitt
Graham D. Pavitt University of Manchester
Alexis Nzila
Alexis Nzila King Fahd University of Petroleum and Minerals
Stephen G. Oliver
Stephen G. Oliver University of Cambridge
Kevin Marsh
Kevin Marsh University of Oxford
Alan F. Cowman
Alan F. Cowman Walter and Eliza Hall Institute of Medical Research
Christopher V. Plowe
Christopher V. Plowe University of Maryland, Baltimore

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