What is he best known for?
The fields of study he is best known for:
Paul F. G. Sims spends much of his time researching Plasmodium falciparum, Virology, DHPS, Gene and Genetics.
All of his Plasmodium falciparum and Pyrimethamine and Sulfadoxine investigations are sub-components of the entire Plasmodium falciparum study.
Paul F. G. Sims has researched Virology in several fields, including Drug resistance and Polymerase chain reaction.
Paul F. G. Sims studied DHPS and Dihydropteroate synthase that intersect with Locus.
His study in Gene concentrates on Nucleic acid sequence and Intron.
His Dihydropteroate study combines topics in areas such as Mutation, Point mutation, Dihydrofolate synthase and Dihydrofolate reductase.
His most cited work include:
- Sequence Variation of the Hydroxymethyldihydropterin Pyrophosphokinase: Dihydropteroate Synthase Gene in Lines of the Human Malaria Parasite, Plasmodium falciparum, with Differing Resistance to Sulfadoxine (323 citations)
- Pyrimethamine–sulfadoxine resistance in Plasmodium falciparum: what next? (320 citations)
- Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization. (258 citations)
What are the main themes of his work throughout his whole career to date?
His primary areas of investigation include Gene, Plasmodium falciparum, Biochemistry, Genetics and Molecular biology.
His Gene study frequently draws parallels with other fields, such as Phanerochaete.
His biological study spans a wide range of topics, including Dihydrofolate reductase and Virology.
As a part of the same scientific study, Paul F. G. Sims usually deals with the Virology, concentrating on Drug resistance and frequently concerns with Malaria.
In most of his Genetics studies, his work intersects topics such as Dihydrofolate synthase.
As part of the same scientific family, he usually focuses on DHPS, concentrating on Dihydropteroate synthase and intersecting with Locus.
He most often published in these fields:
- Gene (39.00%)
- Plasmodium falciparum (38.00%)
- Biochemistry (36.00%)
What were the highlights of his more recent work (between 2009-2018)?
- Biochemistry (36.00%)
- Cell biology (13.00%)
- Mass spectrometry (5.00%)
In recent papers he was focusing on the following fields of study:
His primary areas of study are Biochemistry, Cell biology, Mass spectrometry, Eukaryotic translation and EIF4E.
His Biochemistry study frequently links to other fields, such as Plasmodium falciparum.
His studies in Plasmodium falciparum integrate themes in fields like Serine hydroxymethyltransferase and Enzyme.
His research in Cell biology intersects with topics in Psychological repression, Gene expression, Gene and Protein biosynthesis.
The concepts of his Mass spectrometry study are interwoven with issues in Proteome and Cysteine.
His EIF4E study improves the overall literature in Genetics.
Between 2009 and 2018, his most popular works were:
- Global absolute quantification of a proteome: Challenges in the deployment of a QconCAT strategy. (91 citations)
- Direct and Absolute Quantification of over 1800 Yeast Proteins via Selected Reaction Monitoring (68 citations)
- Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up-regulated (66 citations)
In his most recent research, the most cited papers focused on:
His scientific interests lie mostly in Absolute quantification, Biochemistry, Computational biology, Eukaryotic translation and Saccharomyces cerevisiae.
His Yeast, eIF2B, eIF2, Ternary complex and Guanine nucleotide exchange factor investigations are all subjects of Biochemistry research.
Many of his studies involve connections with topics such as Transcriptome and Computational biology.
The study incorporates disciplines such as Translational regulation, EIF4G and Transfer RNA in addition to Eukaryotic translation.
His Translational regulation study is concerned with the larger field of Genetics.
His Saccharomyces cerevisiae research is multidisciplinary, relying on both Stable isotope dilution, Analyte, Analytical chemistry, eIF4A and Transcription preinitiation complex.
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