Manoj T. Duraisingh mainly investigates Plasmodium falciparum, Genetics, Cell biology, Malaria and Gene. His work deals with themes such as Chloroquine, Pharmacology, Antigen and Virology, which intersect with Plasmodium falciparum. His research in Genetics intersects with topics in Population genetics and Genetic diversity.
His Cell biology research integrates issues from Sialic acid, Receptor, Ligand, Microneme and Glycophorin. His Malaria study incorporates themes from Internal medicine, Randomized controlled trial and Allele. His Antigenic variation study integrates concerns from other disciplines, such as Epigenetics and Gene family.
His primary scientific interests are in Plasmodium falciparum, Malaria, Genetics, Virology and Gene. Manoj T. Duraisingh has researched Plasmodium falciparum in several fields, including Receptor, Biochemistry, Cell biology, Chloroquine and Pharmacology. His biological study spans a wide range of topics, including Sialic acid, Glycophorin and Virulence.
His Malaria research is multidisciplinary, incorporating elements of Red blood cell and Drug resistance. His Virology study integrates concerns from other disciplines, such as DHPS, Antigen, Dihydrofolate reductase, Sulfadoxine/pyrimethamine and Antibody. Manoj T. Duraisingh works mostly in the field of Antigenic variation, limiting it down to topics relating to Gene silencing and, in certain cases, Gene family, as a part of the same area of interest.
Manoj T. Duraisingh mostly deals with Plasmodium falciparum, Malaria, Invasion pathways, Plasmodium and Red blood cell. Manoj T. Duraisingh integrates Plasmodium falciparum with Hereditary persistence of fetal hemoglobin in his study. He interconnects Evolutionary biology, Genetic diversity, Selection, Gene and Haplotype in the investigation of issues within Malaria.
The concepts of his Plasmodium study are interwoven with issues in Antigenic variation, Cell cycle, Epigenetics and Microbiology. His work in Red blood cell addresses issues such as Immune system, which are connected to fields such as Virulence and Parasitemia. His studies deal with areas such as Cell culture, Receptor, Membrane, DNA ligase and Fusion protein as well as Cell biology.
Manoj T. Duraisingh spends much of his time researching Gene, Genetics, Cell biology, Plasmodium falciparum and Ex vivo. Manoj T. Duraisingh has included themes like Laverania and Ligand in his Gene study. His study of Recombinant DNA is a part of Genetics.
His Cell biology research is multidisciplinary, relying on both Cell culture, Cell growth, Protein domain, Receptor and Regulation of gene expression. He specializes in Plasmodium falciparum, namely Plasmodium. His Ex vivo research incorporates themes from cDNA library, Transcriptome, Gene expression, Plasmodium vivax and Gametocyte.
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Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum
Cécile Crosnier;Leyla Y. Bustamante;S. Josefin Bartholdson;Amy K. Bei.
Nature (2011)
Heterochromatin Silencing and Locus Repositioning Linked to Regulation of Virulence Genes in Plasmodium falciparum
Manoj T. Duraisingh;Till S. Voss;Allison J. Marty;Allison J. Marty;Michael F. Duffy.
Cell (2005)
Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations.
Alexander Gerd. Maier;Manoj T. Duraisingh;John C. Reeder;Sheral S. Patel.
Nature Medicine (2003)
A genome-wide map of diversity in Plasmodium falciparum.
Sarah K Volkman;Pardis C Sabeti;David DeCaprio;Daniel E Neafsey.
Nature Genetics (2007)
The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand.
R. N. Price;C. Cassar;A. Brockman;M. Duraisingh.
Antimicrobial Agents and Chemotherapy (1999)
Contribution of the pfmdr1 gene to antimalarial drug-resistance.
Manoj T. Duraisingh;Alan F. Cowman.
Acta Tropica (2005)
The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin
Duraisingh;P Jones;I Sambou;L von Seidlein.
Molecular and Biochemical Parasitology (2000)
Phenotypic variation of Plasmodium falciparum merozoite proteins directs receptor targeting for invasion of human erythrocytes.
Manoj T. Duraisingh;Tony Triglia;Stuart A. Ralph;Julian C. Rayner.
The EMBO Journal (2003)
Molecular Mechanism for Switching of P. falciparum Invasion Pathways into Human Erythrocytes
Janine Stubbs;Ken M. Simpson;Tony Triglia;David Plouffe.
Science (2005)
A Plant-Like Kinase in Plasmodium falciparum Regulates Parasite Egress from Erythrocytes
Jeffrey D. Dvorin;Jeffrey D. Dvorin;Derek C. Martyn;Saurabh D. Patel;Saurabh D. Patel;Joshua S. Grimley.
Science (2010)
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