John E. Hyde

Overview

Best Publications

• Sequence Variation of the Hydroxymethyldihydropterin Pyrophosphokinase: Dihydropteroate Synthase Gene in Lines of the Human Malaria Parasite, Plasmodium falciparum, with Differing Resistance to Sulfadoxine

  Darren R. Brooks;Ping Wang;Martin Read;William M. Watkins

  516
  Citations

• Pyrimethamine–sulfadoxine resistance in Plasmodium falciparum: what next?

  Carol Hopkins Sibley;John E Hyde;Paul F.G Sims;Christopher V Plowe

  516
  Citations

• Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization.

  Ping Wang;Martin Read;Paul F. G. Sims;John E. Hyde

  411
  Citations

• Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine-resistant malaria

  Tony Triglia;Ping Wang;Paul F.G. Sims;John E. Hyde

  378
  Citations

• Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins.

  Ping Wang;Chung Shinn Lee;Riad Bayoumi;Abdoulaye Djimde

  372
  Citations

• Major surface antigen gene of a human malaria parasite cloned and expressed in bacteria

  Roger Hall;John E. Hyde;Mike Goman;David L. Simmons

  294
  Citations

• Drug-resistant malaria - an insight.

  John E. Hyde

  285
  Citations

• Prevalence of Toxoplasma gondii in commercial meat products as monitored by polymerase chain reaction--food for thought?

  Tanya V. Aspinall;Damian Marlee;John E. Hyde;Paul F.G. Sims

  270
  Citations

• Drug-resistant malaria.

  John E. Hyde

  267
  Citations

• Mechanisms of resistance of Plasmodium falciparum to antimalarial drugs.

  John E. Hyde

  203
  Citations

• The dihydrofolate reductase-thymidylate synthetase gene in the drug resistance of malaria parasites.

  John E. Hyde

  191
  Citations

• The establishment of genomic DNA libraries for the human malaria parasite Plasmodium falciparum and identification of individual clones by hybridisation

  Michael Goman;Gordon Langsley;John E. Hyde;Nikolai K. Yankovsky

  189
  Citations

• Targeting purine and pyrimidine metabolism in human apicomplexan parasites.

  John E. Hyde

  160
  Citations

• Protocols in Molecular Parasitology

  John E. Hyde

  153
  Citations

• Microtubular organization visualized by immunofluorescence microscopy during erythrocytic schizogony in Plasmodium falciparum and investigation of post-translational modifications of parasite tubulin.

  M. Read;T. Sherwin;S. P. Holloway;K. Gull

  152
  Citations

• Quantitative proteomics of the human malaria parasite Plasmodium falciparum and its application to studies of development and inhibition

  Niroshini Nirmalan;Paul F. G. Sims;John E. Hyde

  149
  Citations

• Polymorphism of the precursor for the major surface antigens of Plasmodium falciparum merozoites: studies at the genetic level.

  Mackay M;Goman M;Bone N;Hyde Je

  146
  Citations

• The Molecular Basis of Sulfonamide Resistance in Toxoplasma gondii and Implications for the Clinical Management of Toxoplasmosis

  Tanya V. Aspinall;David H. M. Joynson;Edward Guy;John E. Hyde

  139
  Citations

• Characterisation of the dihydrofolate reductase-thymidylate synthetase gene from human malaria parasites highly resistant to pyrimethamine.

  Valerie A. Snewin;Susan M. England;Paul F.G. Sims;John E. Hyde

  139
  Citations

• Comparative folate metabolism in humans and malaria parasites (part I): pointers for malaria treatment from cancer chemotherapy.

  Alexis Nzila;Steve A. Ward;Kevin Marsh;Kevin Marsh;Paul F.G. Sims

  137
  Citations