World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
80
Citations
25739
World Ranking
1150
National Ranking
521

Research.com Recognitions

  • 2006 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Charles E. Samuel is affiliated with the University of California, Santa Barbara in the United States. Their research spans several interconnected fields, primarily focusing on biochemistry, genetics, and molecular biology, with significant contributions to medicine.

Their work covers multiple subfields, including:

  • Molecular Biology
  • Infectious Diseases
  • Immunology
  • Cardiology and Cardiovascular Medicine
  • Artificial Intelligence

Main research topics addressed by Charles E. Samuel include:

  • RNA regulation and disease
  • Interferon and immune responses
  • Viral infections and immunology research
  • RNA research and splicing
  • SARS-CoV-2 and COVID-19 research
  • COVID-19 clinical research studies
  • SARS-CoV-2 detection and testing

Recent scholarly output illustrates a focus on viral infections, immune responses, and molecular mechanisms. Examples of recent publications include:

  • "Adenosine Deaminases Acting on RNA (ADARs) and Viral Infections" (2021, Annual Review of Virology)
  • "Formation and Function of Liquid-Like Viral Factories in Negative-Sense Single-Stranded RNA Virus Infections" (2021, Viruses)
  • "Assessment of a Smartphone-Based Loop-Mediated Isothermal Amplification Assay for Detection of SARS-CoV-2 and Influenza Viruses" (2022, JAMA Network Open)
  • "Interferon at the crossroads of SARS-CoV-2 infection and COVID-19 disease" (2023, Journal of Biological Chemistry)
  • "A broad-spectrum synthetic antibiotic that does not evoke bacterial resistance" (2023, EBioMedicine)

Frequent publication venues where Charles E. Samuel's works appear include:

  • Journal of Virology
  • Annual Review of Virology
  • Journal of Biological Chemistry
  • Viruses
  • JAMA Network Open

Collaborations are an important aspect of this scientist's work. Regular co-authors include:

  • Christian K. Pfaller
  • Dzwokai Ma
  • Cyril X. George
  • Douglas M. Heithoff
  • Lucien Barnes

Charles E. Samuel was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2006.

Best Publications

  • Antiviral Actions of Interferons

    Charles E. Samuel

  • Interferons and their actions.

    Sidney Pestka;Jerome A. Langer;Kathryn C. Zoon;Charles E. Samuel

  • Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activities

    Charles E. Samuel

  • Expression and Regulation by Interferon of a Double-Stranded- RNA-Specific Adenosine Deaminase from Human Cells: Evidence for Two Forms of the Deaminase

    J B Patterson;C E Samuel

  • Dynamic landscape and regulation of RNA editing in mammals

    Meng How Tan;Qin Li;Raghuvaran Shanmugam;Robert Piskol

  • The eIF-2 alpha protein kinases, regulators of translation in eukaryotes from yeasts to humans.

    C E Samuel

  • Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2α kinase

    Jan Kitajewski;Robert J. Schneider;Brian Safer;Susan M. Munemitsu

  • The role of gamma interferon in antimicrobial immunity.

    Ronit Shtrichman;Charles E Samuel

  • Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible

    Cyril X. George;Charles E. Samuel

  • cDNA structures and regulation of two interferon-induced human Mx proteins.

    M Aebi;J Fäh;N Hurt;C E Samuel

  • Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral.

    Charles E. Samuel

  • Mechanism of interferon action: phosphorylation of protein synthesis initiation factor eIF-2 in interferon-treated human cells by a ribosome-associated kinase processing site specificity similar to hemin-regulated rabbit reticulocyte kinase.

    Charles E. Samuel

  • Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA‐dependent protein kinase PKR

    Monsef Benkirane;Christine Neuveut;Rene F. Chun;Stephen M. Smith

  • Three-Dimensional Imaging of Lipid Gene-Carriers: Membrane Charge Density Controls Universal Transfection Behavior in Lamellar Cationic Liposome-DNA Complexes

    Alison J. Lin;Nelle L. Slack;Ayesha Ahmad;Cyril X. George

  • RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis

    Simone V Ward;Cyril X George;Megan J Welch;Li-Ying Liou

  • A standardized nomenclature for adenosine deaminases that act on RNA.

    B. L. Bass;Kazuko Nishikura;Walter Keller;Peter H. Seeburg

  • Cationic lipid-DNA complexes for gene therapy: understanding the relationship between complex structure and gene delivery pathways at the molecular level.

    Kai Ewert;Nelle L. Slack;Ayesha Ahmad;Heather M. Evans

  • Structure and gene silencing activities of monovalent and pentavalent cationic lipid vectors complexed with siRNA.

    Nathan F. Bouxsein;Christopher S. McAllister;Kai K. Ewert;Charles E. Samuel

  • Mechanism of Interferon Action: Biochemical and Genetic Evidence for the Intermolecular Association of the RNA-Dependent Protein Kinase PKR from Human Cells

    Laura G. Ortega;Matthew D. Mccotter;Gilbert L. Henry;Stephen J. Mccormack

  • Morphine analgesia in the tail-flick and Formalin pain tests is mediated by different neural systems

    Frances V. Abbott;Ronald Melzack;Charles Samuel

Frequent Co-Authors

Cyrus R. Safinya
Cyrus R. Safinya University of California, Santa Barbara
Roberto Cattaneo
Roberto Cattaneo Mayo Clinic
Wolfgang K. Joklik
Wolfgang K. Joklik Duke University
Kazuko Nishikura
Kazuko Nishikura The Wistar Institute
Michael B. A. Oldstone
Michael B. A. Oldstone Scripps Research Institute
Bertram L. Jacobs
Bertram L. Jacobs Arizona State University
Thomas Shenk
Thomas Shenk Princeton University
Jesse C. Rabinowitz
Jesse C. Rabinowitz University of California, Berkeley
Jin Billy Li
Jin Billy Li Stanford University
Friedemann Weber
Friedemann Weber University of Giessen

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