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Materials Science

D-Index
69
Citations
18306
World Ranking
4609
National Ranking
1224

Research.com Recognitions

  • 1997 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1994 - Fellow of American Physical Society (APS) Citation For xray scattering experiments probing the fundamental nature of the structure and interactions in fluid and ordered membranes

Overview

Cyrus R. Safinya is affiliated with the University of California, Santa Barbara in the United States and has contributed extensively to the fields of biochemistry, genetics, and molecular biology. Their research spans multiple subfields including molecular biology, cell biology, biomaterials, biomedical engineering, and physiology.

Their work covers diverse topics such as microtubule and mitosis dynamics, RNA interference and gene delivery, nanoparticle-based drug delivery, lipid membrane structure and behavior, Alzheimer's disease research and treatments, nanoplatforms for cancer theranostics, and extracellular vesicles in disease.

Frequent co-authors collaborating with Safinya include:

  • Kai K. Ewert
  • Youli Li
  • Stuart C. Feinstein
  • William S. Fisher
  • Leslie Wilson

Several publication venues where Safinya has frequently published are:

  • Biophysical Journal
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Langmuir
  • ACS Applied Materials & Interfaces
  • The European Physical Journal E

Examples of recent papers authored or co-authored by Safinya include:

  • "Cationic Liposomes as Vectors for Nucleic Acid and Hydrophobic Drug Therapeutics," 2021, Pharmaceutics
  • "Paclitaxel loading in cationic liposome vectors is enhanced by replacement of oleoyl with linoleoyl tails with distinct lipid shapes," 2021, Scientific Reports
  • "Paclitaxel-Loaded Cationic Fluid Lipid Nanodiscs and Liposomes with Brush-Conformation PEG Chains Penetrate Breast Tumors and Trigger Caspase-3 Activation," 2022, ACS Applied Materials & Interfaces
  • "Exosomes are secreted at similar densities by M21 and PC3 human cancer cells and show paclitaxel solubility," 2021, Biochimica et Biophysica Acta (BBA) - Biomembranes
  • "Assembly of Building Blocks by Double-End-Anchored Polymers in the Dilute Regime Mediated by Hydrophobic Interactions at Controlled Distances," 2020, ACS Applied Materials & Interfaces

Safinya has been recognized by peers in their field through awards such as being named a Fellow of the American Association for the Advancement of Science (AAAS) in 1997 and a Fellow of the American Physical Society (APS) in 1994, the latter accompanied by a citation for x-ray scattering experiments exploring the structure and interactions in fluid and ordered membranes.

Best Publications

  • Structure of DNA-Cationic Liposome Complexes: DNA Intercalation in Multilamellar Membranes in Distinct Interhelical Packing Regimes

    Joachim O. Rädler;Ilya Koltover;Tim Salditt;Cyrus R. Safinya

  • Antiferromagnetism in La 2 CuO 4-y

    D. Vaknin;S. K. Sinha;D. E. Moncton;D. C. Johnston

  • "Chevron" local layer structure in surface-stabilized ferroelectric smectic-C cells.

    T. P. Rieker;N. A. Clark;G. S. Smith;G. S. Smith;D. S. Parmar

  • Steric interactions in a model multimembrane system: A synchrotron x-ray study.

    C. R. Safinya;D. Roux;D. Roux;G. S. Smith;G. S. Smith;S. K. Sinha

  • Structures of lipid-DNA complexes: supramolecular assembly and gene delivery.

    Cyrus R Safinya

  • A synchrotron X-ray study of competing undulation and electrostatic interlayer interactions in fluid multimembrane lyotropic phases

    D. Roux;C.R. Safinya

  • Universality in interacting membranes: The effect of cosurfactants on the interfacial rigidity.

    Safinya Cr;Sirota Eb;Roux D;Smith Gs

  • Phase Diagram, Stability, and Overcharging of Lamellar Cationic Lipid–DNA Self-Assembled Complexes

    I. Koltover;T. Salditt;C.R. Safinya

  • Three-Dimensional Imaging of Lipid Gene-Carriers: Membrane Charge Density Controls Universal Transfection Behavior in Lamellar Cationic Liposome-DNA Complexes

    Alison J. Lin;Nelle L. Slack;Ayesha Ahmad;Cyril X. George

  • Structure of the L β phases in a hydrated phosphatidylcholine multimembrane

    G. S. Smith;G. S. Smith;E. B. Sirota;E. B. Sirota;C. R. Safinya;C. R. Safinya;N. A. Clark;N. A. Clark

  • Hierarchical self-assembly of F-actin and cationic lipid complexes: stacked three-layer tubule networks.

    Gerard C. L. Wong;Jay X. Tang;Alison Lin;Youli Li

  • Structure of aggregated gold colloids.

    P. Dimon;S. K. Sinha;D. A. Weitz;C. R. Safinya

  • A columnar phase of dendritic lipid-based cationic liposome-DNA complexes for gene delivery: hexagonally ordered cylindrical micelles embedded in a DNA honeycomb lattice.

    Kai K. Ewert;Heather M. Evans;Alexandra Zidovska;Nathan F. Bouxsein

  • DNA condensation in two dimensions.

    Ilya Koltover;Kathrin Wagner;Cyrus R. Safinya

  • Cationic lipid-DNA complexes for gene therapy: understanding the relationship between complex structure and gene delivery pathways at the molecular level.

    Kai Ewert;Nelle L. Slack;Ayesha Ahmad;Heather M. Evans

  • Two-Dimensional Smectic Ordering of Linear DNA Chains in Self-Assembled DNA-Cationic Liposome Mixtures

    T. Salditt;I. Koltover;J. O. Rädler;C. R. Safinya

  • Lamellar biogels: fluid-membrane-based hydrogels containing polymer lipids.

    Heidi E. Warriner;Stefan H. J. Idziak;Nelle L. Slack;Patrick Davidson

  • Structure and gene silencing activities of monovalent and pentavalent cationic lipid vectors complexed with siRNA.

    Nathan F. Bouxsein;Christopher S. McAllister;Kai K. Ewert;Charles E. Samuel

  • Stabilization of the membrane protein bacteriorhodopsin to 140 °C in two-dimensional films

    Yi Shen;Cyrus R. Safinya;Keng S. Liang;A. F. Ruppert

  • Lipid Tubule Self-Assembly: Length Dependence on Cooling Rate Through a First-Order Phase Transition

    Britt N. Thomas;Cyrus R. Safinya;Robert J. Plano;Noel A. Clark

  • Macromolecules at Surfaces: Research Challenges and Opportunities from Tribology to Biology

    Steve Granick;Sanat K. Kumar;Eric J. Amis;Markus Antonietti

Frequent Co-Authors

Leslie Wilson
Leslie Wilson University of California, San Francisco
Charles E. Samuel
Charles E. Samuel University of California, Santa Barbara
Noel A. Clark
Noel A. Clark University of Colorado Boulder
Jacob N. Israelachvili
Jacob N. Israelachvili University of California, Santa Barbara
Eric B. Sirota
Eric B. Sirota MSD (United States)
Tambet Teesalu
Tambet Teesalu University of Tartu
Joachim O. Rädler
Joachim O. Rädler Ludwig-Maximilians-Universität München
Patrick Davidson
Patrick Davidson University of Paris-Saclay
Robert J. Birgeneau
Robert J. Birgeneau Lawrence Berkeley National Laboratory
Hans-Werner Schmidt
Hans-Werner Schmidt University of Bayreuth

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