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Biology and Biochemistry

D-Index
84
Citations
26410
World Ranking
3300
National Ranking
1671

Medicine

D-Index
84
Citations
26191
World Ranking
15084
National Ranking
7616

Overview

David A. Frank is affiliated with Harvard University in the United States. Their research is primarily focused within the field of Medicine, reflecting a broad engagement with oncology, molecular biology, hematology, immunology, and pulmonary and respiratory medicine.

The scientist's work emphasizes several main topics, including cytokine signaling pathways and interactions, acute myeloid leukemia research, chronic lymphocytic leukemia research, myeloproliferative neoplasms diagnosis and treatment, chronic myeloid leukemia treatments, cancer mechanisms and therapy, and renal diseases and glomerulopathies.

David A. Frank has published extensively in a variety of scientific journals. Notable recent papers include:

  • STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications, 2021, Neoplasia
  • JAK-STAT Signaling in Inflammatory Breast Cancer Enables Chemotherapy-Resistant Cell States, 2022, Cancer Research
  • Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability, 2021, Disease Models & Mechanisms
  • The complementary roles of STAT3 and STAT1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies, 2023, Frontiers in Immunology
  • The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase, 2021, Journal of Biological Chemistry

The publication venues where David A. Frank most frequently publishes include:

  • Blood
  • Clinical Cancer Research
  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology

Prominent frequent co-authors in their research include:

  • Isidora Tošić
  • Sarah R. Walker
  • Weiyuan Wang
  • Lisa N. Heppler
  • Jennifer I. Brown

Best Publications

  • Regulation of Gliogenesis in the Central Nervous System by the JAK-STAT Signaling Pathway

    Azad Bonni;Yi Sun;Mireya Nadal-Vicens;Ami Bhatt

  • The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

    Lauren L.C. Marotta;Vanessa Almendro;Vanessa Almendro;Andriy Marusyk;Michail Shipitsin

  • Sp1 elements protect a CpG island from de novo methylation

    M Brandeis;D Frank;I Keshet;Z Siegfried

  • IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo

    Emmanuel Zorn;Erik A. Nelson;Mehrdad Mohseni;Fabrice Porcheray

  • Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants

    Heidi Greulich;Tzu-Hsiu Chen;Tzu-Hsiu Chen;Whei Feng;Whei Feng;Pasi A Jänne;Pasi A Jänne

  • A candidate prostate cancer susceptibility gene at chromosome 17p.

    Sean V. Tavtigian;Jacques Simard;David H F Teng;Vicki Abtin

  • Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways.

    Jack L. Arbiser;Marsha A. Moses;Cecilia A. Fernandez;Neil Ghiso

  • Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl.

    Nadia Carlesso;David A. Frank;James D. Griffin

  • Whole exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors

    Juliann Chmielecki;Aimee M Crago;Mara Rosenberg;Rachael O'Connor

  • CREB: A mediator of long-term memory from mollusks to mammals

    David A. Frank;David A. Frank;Michael E. Greenberg;Michael E. Greenberg

  • Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo

    Xianhe Bai;Francesca Cerimele;Masuko Ushio-Fukai;Muhammad Waqas

  • STAT3 as a central mediator of neoplastic cellular transformation

    David A. Frank

  • Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia

    Akinori Yoda;Yuka Yoda;Sabina Chiaretti;Michal Bar-Natan

  • Techniques in molecular biology

    John M. Walker;Wim Gaastra

  • Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling

    David A. Frank;Sudipta Mahajan;Jerome Ritz

  • The role of STATs in apoptosis.

    T E Battle;D A Frank

  • CREB in the Pathophysiology of Cancer: Implications for Targeting Transcription Factors for Cancer Therapy

    Kathleen M. Sakamoto;David A. Frank

  • Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein.

    James Turkson;Tammy Bowman;Jalila Adnane;Yi Zhang

  • B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues.

    D A Frank;S Mahajan;J Ritz

  • CREB: A Mediator of Long-Term Memory from Mollusks to Mammals Minireview

    David A. Frank;Michael E. Greenberg

Frequent Co-Authors

James D. Griffin
James D. Griffin Harvard University
Jerome Ritz
Jerome Ritz Harvard University
Jack L. Arbiser
Jack L. Arbiser Emory University
Michael E. Greenberg
Michael E. Greenberg Harvard University
Matthew Meyerson
Matthew Meyerson Harvard University
Richard Stone
Richard Stone Harvard University
Ellen Weisberg
Ellen Weisberg Harvard University
Martin Sattler
Martin Sattler Harvard University
Andrea L. Richardson
Andrea L. Richardson Johns Hopkins University
Donna Neuberg
Donna Neuberg Harvard University

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