David A. Frank focuses on Cancer research, Molecular biology, Signal transduction, STAT3 and Cell biology. David A. Frank has researched Cancer research in several fields, including Cytokine, Carcinogenesis, ABL, Gefitinib and breakpoint cluster region. His Molecular biology research integrates issues from Fusion gene and SH2 domain, Proto-oncogene tyrosine-protein kinase Src, Phosphorylation, Tyrosine phosphorylation.
His Signal transduction research is multidisciplinary, incorporating elements of Leukemia, Transcription and In vivo. His work deals with themes such as Transcription factor and STAT1, which intersect with STAT3. His studies in Cell biology integrate themes in fields like Antigen, Interleukin 2, Regulation of gene expression, Ciliary neurotrophic factor and FOXP3.
David A. Frank mainly investigates Cancer research, STAT3, Transcription factor, Signal transduction and Cell biology. His Cancer research research incorporates elements of Carcinogenesis, Cancer, Breast cancer, Tyrosine kinase and STAT protein. His study looks at the relationship between Transcription factor and topics such as Gene expression, which overlap with Transcription.
His Signal transduction research includes elements of Kinase, Immunology and Autocrine signalling. His study in Cell biology is interdisciplinary in nature, drawing from both Cytokine, Interleukin 12, IL-2 receptor and Cellular differentiation. His Tyrosine phosphorylation study combines topics from a wide range of disciplines, such as Molecular biology and STAT1.
Cancer research, STAT3, Cancer, Transcription factor and Cancer cell are his primary areas of study. His work on Myeloid leukemia as part of general Cancer research research is often related to Atovaquone, thus linking different fields of science. His research in the fields of STAT protein overlaps with other disciplines such as Pyrimethamine.
The various areas that he examines in his Cancer study include Tyrosine kinase, Signal transduction, Transcriptome and Oncology. His work investigates the relationship between Signal transduction and topics such as Tumor microenvironment that intersect with problems in Targeted therapy and Angiogenesis. His work in Transcription factor tackles topics such as Gene expression which are related to areas like Advanced ovarian cancer and Identification.
His primary scientific interests are in Cancer research, Myeloid leukemia, Gene knockdown, STAT3 and Breast cancer. His studies deal with areas such as Cancer, Leukemia, PI3K/AKT/mTOR pathway, Kinase and MCL1 as well as Cancer research. He combines subjects such as Myeloid, CHOP and Mechanistic target of rapamycin with his study of Myeloid leukemia.
His STAT3 study combines topics in areas such as Carcinogenesis, Cytotoxic T cell and Tumor microenvironment. His Carcinogenesis study frequently draws connections to other fields, such as Signal transduction. His work carried out in the field of Breast cancer brings together such families of science as Regulation of gene expression, Transcription factor, Gene and Gene expression.
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Regulation of Gliogenesis in the Central Nervous System by the JAK-STAT Signaling Pathway
Azad Bonni;Yi Sun;Mireya Nadal-Vicens;Ami Bhatt.
Sp1 elements protect a CpG island from de novo methylation
M Brandeis;D Frank;I Keshet;Z Siegfried.
The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors
Lauren L.C. Marotta;Vanessa Almendro;Vanessa Almendro;Andriy Marusyk;Michail Shipitsin.
Journal of Clinical Investigation (2011)
IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo
Emmanuel Zorn;Erik A. Nelson;Mehrdad Mohseni;Fabrice Porcheray.
Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants
Heidi Greulich;Tzu-Hsiu Chen;Tzu-Hsiu Chen;Whei Feng;Whei Feng;Pasi A Jänne;Pasi A Jänne.
PLOS Medicine (2005)
A candidate prostate cancer susceptibility gene at chromosome 17p.
Sean V. Tavtigian;Jacques Simard;David H F Teng;Vicki Abtin.
Nature Genetics (2001)
Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways.
Jack L. Arbiser;Marsha A. Moses;Cecilia A. Fernandez;Neil Ghiso.
Proceedings of the National Academy of Sciences of the United States of America (1997)
Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl.
Nadia Carlesso;David A. Frank;James D. Griffin.
Journal of Experimental Medicine (1996)
Whole exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors
Juliann Chmielecki;Aimee M Crago;Mara Rosenberg;Rachael O'Connor.
Nature Genetics (2013)
CREB: A mediator of long-term memory from mollusks to mammals
David A. Frank;David A. Frank;Michael E. Greenberg;Michael E. Greenberg.
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