What is he best known for?
The fields of study he is best known for:
David A. Frank focuses on Cancer research, Molecular biology, Signal transduction, STAT3 and Cell biology.
David A. Frank has researched Cancer research in several fields, including Cytokine, Carcinogenesis, ABL, Gefitinib and breakpoint cluster region.
His Molecular biology research integrates issues from Fusion gene and SH2 domain, Proto-oncogene tyrosine-protein kinase Src, Phosphorylation, Tyrosine phosphorylation.
His Signal transduction research is multidisciplinary, incorporating elements of Leukemia, Transcription and In vivo.
His work deals with themes such as Transcription factor and STAT1, which intersect with STAT3.
His studies in Cell biology integrate themes in fields like Antigen, Interleukin 2, Regulation of gene expression, Ciliary neurotrophic factor and FOXP3.
His most cited work include:
- Regulation of Gliogenesis in the Central Nervous System by the JAK-STAT Signaling Pathway (859 citations)
- Sp1 elements protect a CpG island from de novo methylation (660 citations)
- The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors (624 citations)
What are the main themes of his work throughout his whole career to date?
David A. Frank mainly investigates Cancer research, STAT3, Transcription factor, Signal transduction and Cell biology.
His Cancer research research incorporates elements of Carcinogenesis, Cancer, Breast cancer, Tyrosine kinase and STAT protein.
His study looks at the relationship between Transcription factor and topics such as Gene expression, which overlap with Transcription.
His Signal transduction research includes elements of Kinase, Immunology and Autocrine signalling.
His study in Cell biology is interdisciplinary in nature, drawing from both Cytokine, Interleukin 12, IL-2 receptor and Cellular differentiation.
His Tyrosine phosphorylation study combines topics from a wide range of disciplines, such as Molecular biology and STAT1.
He most often published in these fields:
- Cancer research (63.78%)
- STAT3 (33.07%)
- Transcription factor (30.31%)
What were the highlights of his more recent work (between 2017-2021)?
- Cancer research (63.78%)
- STAT3 (33.07%)
- Cancer (12.60%)
In recent papers he was focusing on the following fields of study:
Cancer research, STAT3, Cancer, Transcription factor and Cancer cell are his primary areas of study.
His work on Myeloid leukemia as part of general Cancer research research is often related to Atovaquone, thus linking different fields of science.
His research in the fields of STAT protein overlaps with other disciplines such as Pyrimethamine.
The various areas that he examines in his Cancer study include Tyrosine kinase, Signal transduction, Transcriptome and Oncology.
His work investigates the relationship between Signal transduction and topics such as Tumor microenvironment that intersect with problems in Targeted therapy and Angiogenesis.
His work in Transcription factor tackles topics such as Gene expression which are related to areas like Advanced ovarian cancer and Identification.
Between 2017 and 2021, his most popular works were:
- IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment. (62 citations)
- The STAT3 inhibitor pyrimethamine displays anti-cancer and immune stimulatory effects in murine models of breast cancer (37 citations)
- Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells (27 citations)
In his most recent research, the most cited papers focused on:
His primary scientific interests are in Cancer research, Myeloid leukemia, Gene knockdown, STAT3 and Breast cancer.
His studies deal with areas such as Cancer, Leukemia, PI3K/AKT/mTOR pathway, Kinase and MCL1 as well as Cancer research.
He combines subjects such as Myeloid, CHOP and Mechanistic target of rapamycin with his study of Myeloid leukemia.
His STAT3 study combines topics in areas such as Carcinogenesis, Cytotoxic T cell and Tumor microenvironment.
His Carcinogenesis study frequently draws connections to other fields, such as Signal transduction.
His work carried out in the field of Breast cancer brings together such families of science as Regulation of gene expression, Transcription factor, Gene and Gene expression.
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