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Microbiology

D-Index
68
Citations
14180
World Ranking
2191
National Ranking
913

Overview

Nigel W. Fraser is affiliated with the University of Pennsylvania in the United States. Their work primarily focuses on the fields of Medicine and Immunology and Microbiology, contributing notably to the study of herpesvirus infections and immune responses.

The scientist's research spans several subfields, including Epidemiology, Immunology, Molecular Biology, Public Health, Environmental and Occupational Health, and Ophthalmology. Their research integrates these disciplines to explore viral pathogenesis, immune interactions, and disease mechanisms.

Among the main topics covered in their work are herpesvirus infections and treatments, interferon and immune responses, cytomegalovirus and herpesvirus research, ocular surface and contact lens-related studies, ocular infections and treatments, pharmacological effects of natural compounds, and toxin mechanisms and immunotoxins.

Nigel W. Fraser has published extensively in a range of scientific journals. Frequent venues for their work include:

  • Virology Journal
  • Journal of NeuroVirology
  • Virologica Sinica
  • Cell Reports
  • Scientific Reports

Their recent published papers include:

  • Cohesin promotes HSV-1 lytic transcription by facilitating the binding of RNA Pol II on viral genes, 2021, Virology Journal
  • HSV-1 infection and pathogenesis in the tree shrew eye following corneal inoculation, 2020, Journal of NeuroVirology
  • Longitudinal transcriptomic characterization of viral genes in HSV-1 infected tree shrew trigeminal ganglia, 2020, Virology Journal
  • Persistent inflammation and neuronal loss in the mouse brain induced by a modified form of attenuated herpes simplex virus type I, 2022, Virologica Sinica
  • ICP22-defined condensates mediate RNAPII deubiquitylation by UL36 and promote HSV-1 transcription, 2024, Cell Reports

Collaboration forms a significant aspect of Nigel W. Fraser's research contributions. Frequent co-authors in their publications are:

  • Guijun Chen
  • Jumin Zhou
  • Erlin Wang
  • Liping Yang
  • Xia Cao

The combined research outputs and collaborations illustrate a focus on herpes simplex virus type 1 (HSV-1), its transcriptional mechanisms, pathogenesis, and immune response interactions. Their work contributes to the understanding of viral gene regulation, ocular and neural infections, and inflammation induced by attenuated viral forms.

Best Publications

  • In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases

    Hilary Koprowski;Yong Mu Zheng;Ellen Heber-Katz;Nigel Fraser

  • Detection of HSV-1 genome in central nervous system of latently infected mice

    Daniel L. Rock;Nigel W. Fraser

  • Detection of herpes simplex virus type 1 transcripts during latent infection in mice.

    J G Spivack;N W Fraser

  • During latency, herpes simplex virus type 1 DNA is associated with nucleosomes in a chromatin structure.

    S L Deshmane;N W Fraser

  • Retraction Note: Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript

    A. Gupta;J. J. Gartner;P. Sethupathy;A. G. Hatzigeorgiou

  • Herpes simplex virus type 1 latency-associated transcripts are evidently not essential for latent infection.

    I Steiner;J G Spivack;R P Lirette;S M Brown

  • Herpes simplex type 1 DNA in human brain tissue.

    Nigel W. Fraser;William C. Lawrence;Zofia Wroblewska;Donald H. Gilden

  • Physical state of the latent herpes simplex virus genome in a mouse model system: evidence suggesting an episomal state.

    D.M. Mellerick;N.W. Fraser

  • Localization of herpes simplex virus in the trigeminal and olfactory systems of the mouse central nervous system during acute and latent infections by in situ hybridization.

    W G Stroop;D L Rock;N W Fraser

  • RNA from an immediate early region of the type 1 herpes simplex virus genome is present in the trigeminal ganglia of latently infected mice.

    Anne M. Deatly;Jordan G. Spivack;Ehud Lavi;Nigel W. Fraser

  • The initiation sites for RNA transcription in Ad2 DNA.

    Ronald M. Evans;Nigel Fraser;Edward Ziff;Jeffrey Weber

  • A herpes simplex virus type 1 mutant containing a nontransinducing Vmw65 protein establishes latent infection in vivo in the absence of viral replication and reactivates efficiently from explanted trigeminal ganglia.

    I Steiner;J G Spivack;S L Deshmane;C I Ace

  • Herpesvirus vector gene transfer and expression of β–glucuronidase in the central nervous system of MRS VII mice

    John H. Wolfe;Satish L. Deshmane;Nigel W. Fraser

  • During Lytic Infection Herpes Simplex Virus Type 1 Is Associated with Histones Bearing Modifications That Correlate with Active Transcription

    J. R. Kent;P.-Y. Zeng;D. Atanasiu;J. Gardner

  • Regions of the Herpes Simplex Virus Type 1 Latency-Associated Transcript That Protect Cells from Apoptosis In Vitro and Protect Neuronal Cells In Vivo

    Maryam Ahmed;Martin Lock;Cathie G. Miller;Nigel W. Fraser

  • Latent herpes simplex virus type 1 transcripts in peripheral and central nervous system tissues of mice map to similar regions of the viral genome

    A M Deatly;J G Spivack;E Lavi;nd D R O'Boyle

  • In vivo and in vitro reactivation impairment of a herpes simplex virus type 1 latency-associated transcript variant in a rabbit eye model.

    M D Trousdale;I Steiner;J G Spivack;S L Deshmane

  • Expression of herpes simplex virus type 1 latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection.

    J G Spivack;N W Fraser

  • Gene expression during reactivation of herpes simplex virus type 1 from latency in the peripheral nervous system is different from that during lytic infection of tissue cultures.

    Ruth Tal-Singer;Todd M. Lasner;Wawrzyniec Podrzucki;Aikaterini Skokotas

  • Temporal Association of the Herpes Simplex Virus Genome with Histone Proteins during a Lytic Infection

    Jaewook Oh;Nigel W. Fraser

  • Corrections: In vivo Expression of Inducible Nitric Oxide Synthase in Experimentally Induced Neurologic Diseases

    Hilary Koprowski;Yong Mu Zheng;Ellen Heber-Katz;Nigel Fraser

Frequent Co-Authors

John H. Wolfe
John H. Wolfe University of Pennsylvania
Timothy M. Block
Timothy M. Block Drexel University
Shelley L. Berger
Shelley L. Berger University of Pennsylvania
James E. Darnell
James E. Darnell Rockefeller University
John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania
Virginia M.-Y. Lee
Virginia M.-Y. Lee University of Pennsylvania
Daniel L. Rock
Daniel L. Rock University of Illinois at Urbana-Champaign
Steven M. Albelda
Steven M. Albelda University of Pennsylvania
Ehud Lavi
Ehud Lavi Cornell University
Anand Mehta
Anand Mehta Medical University of South Carolina

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