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Microbiology

D-Index
90
Citations
26390
World Ranking
695
National Ranking
323

Medicine

D-Index
90
Citations
26332
World Ranking
12323
National Ranking
6310

Overview

Donald M. Coen is a researcher affiliated with Harvard University in the United States. Their work is primarily situated in the fields of Medicine and Immunology and Microbiology, with a strong focus on epidemiology, immunology, molecular biology, virology, and cardiology and cardiovascular medicine as relevant subfields.

Their research topics concentrate on herpesvirus infections and treatments, cytomegalovirus and herpesvirus research, RNA regulation and disease, interferon and immune responses, viral infections and immunology research, toxin mechanisms and immunotoxins, and HIV research and treatment.

Notable recent publications by Donald M. Coen include:

  • "Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency" (2021, Nature Microbiology)
  • "Linking indirect effects of cytomegalovirus in transplantation to modulation of monocyte innate immune function" (2020, Science Advances)
  • "Human cytomegalovirus-induced host protein citrullination is crucial for viral replication" (2021, Nature Communications)
  • "Neuronal miR-9 promotes HSV-1 epigenetic silencing and latency by repressing Oct-1 and Onecut family genes" (2024, Nature Communications)
  • "Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance" (2024, Cell)

Frequent collaborators in their research include Jean M. Pesola, Hyung Suk Oh, David M. Knipe, Han Chen, and James M. Hogle.

Donald M. Coen's work has been published multiple times in a variety of venues, with recurring publications in:

  • Virology
  • Nature Communications
  • mBio
  • Nature Microbiology
  • Science Advances

Best Publications

  • A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress

    Michael Boyce;Kevin F. Bryant;Céline Jousse;Kai Long

  • Experimental therapy of human glioma by means of a genetically engineered virus mutant

    R. L. Martuza;A. Malick;J. M. Markert;K. L. Ruffner

  • MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs

    Jennifer Lin Umbach;Martha F. Kramer;Igor Jurak;Heather W. Karnowski

  • A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells

    V. Sullivan;C. L. Talarico;S. C. Stanat;M. Davis

  • Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate

    Donald M. Coen;Magdalena Kosz-Vnenchak;Jennie G. Jacobson;David A. Leib

  • Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency.

    D A Leib;D M Coen;C L Bogard;K A Hicks

  • A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency

    D A Leib;C L Bogard;M Kosz-Vnenchak;K A Hicks

  • Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1

    Donald M. Coen;Priscilla A. Schaffer

  • Antiherpesvirus drugs: a promising spectrum of new drugs and drug targets

    Donald M. Coen;Priscilla A. Schaffer

  • The herpes simplex virus type 1 regulatory protein ICP0 enhances virus replication during acute infection and reactivation from latency.

    Weizhong Cai;T. L. Astor;L. M. Liptak;C. Cho

  • Herpesviral latency-associated transcript gene promotes assembly of heterochromatin on viral lytic-gene promoters in latent infection.

    Qing-Yin Wang;Changhong Zhou;Karen E. Johnson;Robert C. Colgrove

  • Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virus.

    M F Kramer;D M Coen

  • Maize plastid gene expressed during photoregulated development.

    John R. Bedbrook;Gerhard Link;Donald M. Coen;Lawrence Bogorad

  • The human cytomegalovirus UL97 protein kinase, an antiviral drug target, is required at the stage of nuclear egress.

    Paula M. Krosky;Moon-Chang Baek;Donald M. Coen

  • The herpes simplex virus type 1 UL42 gene product: a subunit of DNA polymerase that functions to increase processivity.

    J Gottlieb;A I Marcy;D M Coen;M D Challberg

  • Prediction and identification of herpes simplex virus 1-encoded microRNAs

    Can Cui;Anthony Griffiths;Guanglin Li;Lindsey M. Silva

  • Enzymatic amplification of DNA by PCR: standard procedures and optimization.

    Martha F. Kramer;Donald M. Coen

  • Herpes Simplex Viruses: Mechanisms of DNA Replication

    Sandra K. Weller;Donald M. Coen

  • Reduction and elimination of encephalitis in an experimental glioma therapy model with attenuated herpes simplex mutants that retain susceptibility to acyclovir.

    James M. Markert;Amy Malick;Donald M. Coen;Robert L. Martuza

  • Quantitative polymerase chain reaction analysis of herpes simplex virus DNA in ganglia of mice infected with replication-incompetent mutants.

    J P Katz;E T Bodin;D M Coen

  • A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactivatable latent infections of mice and for replication in mouse cells.

    Jennie G. Jacobson;David A. Leib;David J. Goldstein;Connie L. Bogard

Frequent Co-Authors

David M. Knipe
David M. Knipe Harvard University
James M. Hogle
James M. Hogle Harvard University
Priscilla A. Schaffer
Priscilla A. Schaffer Beth Israel Deaconess Medical Center
Sandra K. Weller
Sandra K. Weller University of Connecticut
Shun Hua Chen
Shun Hua Chen National Cheng Kung University
Robert L. Martuza
Robert L. Martuza Harvard Medical School
Paul Digard
Paul Digard University of Edinburgh
David A. Leib
David A. Leib Dartmouth College
Lawrence Bogorad
Lawrence Bogorad Harvard University

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